Results for BIOC

Preference to sophomores. Knowledge gained from sequencing human genomes and implications for medicine and biomedical research. Novel diagnoses and treatment of diseases, including stem cells, gene therapy and rational drug design. Personal genomics and how it is used to improve health and well being. Social and ethical implications of genetic information such as privacy, discrimination and insurability. Course Webpage: http://biochem118.stanford.edu/.

Molecular basis of inherited human disease. Diagnostics approaches: simple Mendelian diseases and complex, multifactorial diseases. Genomics: functional genomics, epigenetics, gene expression, SNPs, copy number and other structural genomic variations involved in disease. Novel therapeutic methods: stem cell therapy, gene therapy and drug developments that depend on the knowledge of genomics. Personal genomics, pharmacogenomics, clinical genomics and their role in the future of preventive medicine. Prerequisites: BIO 41 or HUMBIO 2A or consent of instructor. Those with credit in BIOC 118 not eligible to enroll. Course webpage: http://biochem158.stanford.edu/

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

Enrollment limited to MD candidates. Fundamental concepts of biochemistry as applied to clinical medicine. Topics include thermodynamics, enzyme kinetics, vitamins and cofactors, metabolism of carbohydrates, lipids, amino acids and nucleotides, and the integration of metabolic pathways. Clinical case studies discussed in small-group, problem-based learning sessions.

Open to first year Biochemistry students or consent of instructor. Hands-on, five-day immersion in biochemical methods and practice, theory and application of light microscopy, and computational approaches to modern biological problems.

For medical students. Topics include DNA structure, replication, repair, and recombination; gene expression, including mechanisms for regulating transcription and translation; chromosome structure and function; gene cloning, protein engineering, and genomics. Patient presentations and journal clubs illustrate how molecular biology affects the practice of medicine.

The structure, function, and biosynthesis of cellular membranes and organelles. Current literature. Prerequisite: consent of instructor.

Literature discussion in conjunction with the Frontiers in Biological Research seminar series in which investigators present current work. Students and faculty meet beforehand to discuss papers from the speaker¿s primary research literature. Students meet with the speaker after the seminar to discuss their research and future direction, commonly used techniques to study problems in biology, and comparison between the genetic and biochemical approaches in biological research.

Practical, hands-on approach to field of computational molecular biology. Recommended for molecular biologists and computer scientists desiring to understand the major issues concerning analysis of genomes, sequences and structures. Various existing methods critically described and strengths and limitations of each. Practical assignments utilizing tools described. All homework and coursework submitted electronically. Course webpage: http://biochem218.stanford.edu/.

Required for teaching assistants in Biochemistry. Practical experience in teaching on a one-to-one basis, and problem set design and analysis. Familiarization with current lecture and text materials; evaluations of class papers and examinations. Prerequisite: enrollment in the Biochemistry Ph.D. program or consent of instructor.

For Ph.D. students. Current research on cell structure, function, and dynamics. Topics include complex cell phenomena such as cell division, apoptosis, compartmentalization, transport and trafficking, motility and adhesion, differentiation, and multicellularity. Current papers from the primary literature. Prerequisite for advanced undergraduates: BIO 129A,B, and consent of instructor.

The physical and chemical basis of macromolecular function. Forces that stabilize biopolymers with three-dimensional structures and their functional implications. Thermodynamics, molecular forces, structure and kinetics of enzymatic and diffusional processes, and relationship to their practical application in experimental design and interpretation. Biological function and the level of individual molecular interactions and at the level of complex processes. Case studies in lecture and discussion of classic and current literature. Enrollment limited to 30. Prerequisites: None; background in biochemistry and physical chemistry preferred but material available for those with deficiency; undergraduates with consent of instructor only.

Seminars by Biochemistry faculty on their ongoing research. Background, current advances and retreats, general significance, and tactical and strategic research directions.

Molecular basis of inherited human disease. Diagnostics approaches: simple Mendelian diseases and complex, multifactorial diseases. Genomics: functional genomics, epigenetics, gene expression, SNPs, copy number and other structural genomic variations involved in disease. Novel therapeutic methods: stem cell therapy, gene therapy and drug developments that depend on the knowledge of genomics. Personal genomics, pharmacogenomics, clinical genomics and their role in the future of preventive medicine. Prerequisites: BIO 41 or HUMBIO 2A or consent of instructor. Those with credit in BIOC 118 not eligible to enroll. Course webpage: http://biochem158.stanford.edu/

Prerequisite: consent of instructor. (Staff)

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.

Allows for qualified students to undertake investigations sponsored by individual faculty members.

Students register through their affiliated department; otherwise register for CHEMENG 459. For specialists and non-specialists. Sponsored by the Stanford BioX Program. Three seminars per quarter address scientific and technical themes related to interdisciplinary approaches in bioengineering, medicine, and the chemical, physical, and biological sciences. Leading investigators from Stanford and the world present breakthroughs and endeavors that cut across core disciplines. Pre-seminars introduce basic concepts and background for non-experts. Registered students attend all pre-seminars; others welcome. See http://biox.stanford.edu/courses/459.html. Recommended: basic mathematics, biology, chemistry, and physics.

Literature-based lectures and discussion on rapidly developing frontiers in chromosome structure and function and modern insights into the control of gene expression. Emphasis is on experimental approaches and insights. Topics include chromosome organization, novel modes of transcriptional control, RNA-based mechanisms for controlling gene expression and emerging translational regulatory mechanisms. Prerequisite: undergraduate molecular biology.

The principles of organic and physical chemistry as applied to biomolecules. Goal is a working knowledge of chemical principles that underlie biological processes, and chemical tools used to study and manipulate biological systems. Prerequisites: organic chemistry and biochemistry, or consent of instructor.

Interdisciplinary analyses from basic biochemistry and biophysics to clinical outcomes of disease states and potential therapeutic interventions (translational research). Focus on cardiac system. Cardiomyopathies arise from missense mutations in cardiac muscle proteins, including the cardiac myosin motor. Single molecule biophysics and classical enzyme kinetics and use of induced pluripotent stem cells (iPS cells) and single cell studies lay foundation for discussions of effects of cardiomyopathy mutations on heart function. Potential therapeutic approaches discussed, including genetic analysis, DNA cloning, reconstitution of functional assemblies, x-ray diffraction and 3D reconstruction of electron microscope images, spectroscopic methods, computational approaches, single molecule biophysics, use of induced pluripotent stem cells in research, and other interdisciplinary approaches. Current papers examined. Prerequisites: basic biochemistry.

For M.D. students who intend to declare a concentration in molecular basis of medicine, MSTP students, and Ph.D. students. Advanced medical biochemistry focusing on cases where molecular-level research has led to new medical treatments or changes in the understanding of important diseases. Different topics each week explore the underlying molecular basis of a variety of diseases and the reasons for success and failure in molecular approaches to treatment. Student-led discussions dissect papers from the primary medical and scientific research literature.

Topics in biology from a quantitative perspective. Subjects vary. 2011-12 focus: evolution, from basic principles of evolutionary dynamics to fundamental quantitative questions that are far from being answered; from early life, metabolic processes, and molding of earth by microbes to spread of human epidemics; from analysis of genomes and molecular phylogenies to aspects of multi-cellular development. Prerequisites: Familiarity with ordinary differential equations and probability. Biology background not required.

Students are presented with requests for advice from faculty and students in the biological sciences and Medical School encountering experimental and analytical problems in their research. Students work with the instructor and other biochemistry faculty to propose solutions. May be repeated for credit.