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RAD 222A: Multimodality Molecular Imaging in Living Subjects I (BIOE 222A)

Focuses on instruments, algorithms and other technologies for imaging of cellular and molecular processes in living subjects. Introduces preclinical and clinical molecular imaging modalities, including strategies for molecular imaging using PET, SPECT, MRI, Ultrasound, and Optics. Covers basics of instrumentation physics, and the origin and properties of the signal generation.
Terms: Aut | Units: 4

RAD 222B: Multimodality Molecular Imaging in Living Subjects II (BIOE 222B)

Focuses on molecular contrast agents (a.k.a. "probes") that interrogate and target specific cellular and molecular disease mechanisms. Covers the ideal characteristics of molecular probes and how to optimize their design for use as effective imaging reagents that enables readout of specific steps in biological pathways and reveal the nature of disease through noninvasive assays.
| Units: 4 | Repeatable 2 times (up to 8 units total)
Instructors: ; Moseley, M. (PI)

RAD 222C: Multimodality Molecular Imaging in Living Subjects III (BIOE 222C)

Covers advanced topics in molecular imaging instrumentation, probes and assays that address unmet needs for improved diagnosis and disease management in cancer, neurological disease, cardiovascular medicine and musculoskeletal disorders. Lecturers identify problems or controversies in the field. The lectures are in the form of a grant proposal covering aims, background and relevance, innovation, proposed approaches to achieving the aims, and a review of the relevant primary literature. Students learn key elements of writing a successful grant proposal in the field of molecular imaging.
Terms: Spr | Units: 4

RAD 223: Physics and Engineering of X-Ray Computed Tomography (BIOE 223)

CT scanning geometries, production of x-rays, interactions of x-rays with matter, 2D and 3D CT reconstruction, image presentation, image quality performance parameters, system components, image artirfacts, radiation dose. Prerequisites: differential and integral calculus. Knowledge of Fourier transforms (EE261) recommended.
Terms: Aut | Units: 3

RAD 225: Ultrasound Imaging and Therapeutic Applications (BIOE 225)

Covers the basic concepts of ultrasound imaging including acoustic properties of biological tissues, transducer hardware, beam formation, and clinical imaging. Also includes the therapeutic applications of ultrasound including thermal and mechanical effects, visualization of the temperature and radiation force with MRI, tissue assessment with MRI and ultrasound, and ultrasound-enhanced drug delivery. Course website: http://bioe325.stanford.edu
Terms: Aut | Units: 3

RAD 226: In Vivo Magnetic Resonance Spectroscopy and Imaging (BIOE 226)

Collections of identical independent nuclear spins are described by the classical vector model of magnetic resonance imaging (MRI); however, interactions among spins, as occur in many in vivo processes, require a more complete description. Physics and engineering principles of these in vivo magnetic resonance phenomena with emphasis on current research questions and clinical applications. Topics: quantum mechanical description of magnetic resonance, density matrix theory, product operator formalism, relaxation theory and contrast mechanisms, spectroscopic imaging, spectral editing, and multinuclear studies. Prerequisites: EE 369B or familiarity with magnetic resonance, working knowledge of linear algebra.
Terms: Win | Units: 3
Instructors: ; Spielman, D. (PI)

RAD 227: Functional MRI Methods (BIOPHYS 227)

Basics of functional magnetic resonance neuroimaging, including data acquisition, analysis, and experimental design. Journal club sections. Cognitive neuroscience and clinical applications. Prerequisites: basic physics, mathematics; neuroscience recommended.
Terms: Win | Units: 3
Instructors: ; Glover, G. (PI)

RAD 260: Computational Methods for Biomedical Image Analysis and Interpretation (BIOMEDIN 260)

The latest biological and medical imaging modalities and their applications in research and medicine. Focus is on computational analytic and interpretive approaches to optimize extraction and use of biological and clinical imaging data for diagnostic and therapeutic translational medical applications. Topics include major image databases, fundamental methods in image processing and quantitative extraction of image features, structured recording of image information including semantic features and ontologies, indexing, search and content-based image retrieval. Case studies include linking image data to genomic, phenotypic and clinical data, developing representations of image phenotypes for use in medical decision support and research applications and the role that biomedical imaging informatics plays in new questions in biomedical science. Includes a project. Enrollment for 3 units with reduced project requirements requires instructor consent. Prerequisites: programming ability at the level of CS 106A, familiarity with statistics, basic biology. Knowledge of Matlab highly recommended.
Terms: Spr | Units: 3-4

RAD 370: Medical Scholars Research

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.
Terms: Aut, Win, Spr, Sum | Units: 4-18 | Repeatable for credit

RAD 220: Introduction to Imaging and Image-based Human Anatomy (BIOE 220)

Focus on learning the fundamentals of each imaging modality including X-ray Imaging, Ultrasound, CT, and MRI, to learn normal human anatomy and how it appears on medical images, to learn the relative strengths of the modalities, and to answer, "What am I looking at?"
| Units: 3

RAD 226: In Vivo Magnetic Resonance Spectroscopy and Imaging

Collections of identical independent nuclear spins are described by the classical vector model of magnetic resonance imaging (MRI); however, interactions among spins, as occur in many in vivo processes, require a more complete description. Physics and engineering principles of these in vivo magnetic resonance phenomena with emphasis on current research questions and clinical applications. Topics: quantum mechanical description of magnetic resonance, density matrix theory, product operator formalism, relaxation theory and contrast mechanisms, spectroscopic imaging, spectral editing, and multinuclear studies. Prerequisites: EE 369B or familiarity with magnetic resonance, working knowledge of linear algebra.
| Units: 3

RAD 228: Magnetic Resonance Imaging Programming Topics

Primarily for students working on research projects involving MRI pulse sequence programming. Introductory and student-initiated topics in seminars and hands-on labs. Image contrast mechanisms achieved by pulse sequences that control radiofrequency and gradient magnetic fields in real time, while acquiring data in an organized manner for image reconstruction. Prerequisites: EE 369B and consent of instructor.
| Units: 3 | Repeatable for credit
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