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What is information? How can we measure and efficiently represent it? How can we reliably communicate and store it over media prone to noise and errors? How can we make sound decisions based on partial and noisy information? This course introduces the basic notions required to address these questions, as well as the principles and techniques underlying the design of modern information, communication, and decision-making systems with relations to and applications in machine-learning, through genomics, to neuroscience. Students will get a hands-on appreciation of the concepts via projects in small groups, where they will develop their own systems for streaming of multi-media data under human-centric performance criteria. Prerequisite: CS 106A.