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This course blends lecture, case discussions, readings about pertinent research, and hands-on projects to learn about what leaders and senior teams can do to bring about broad-based change in complex organizations. Topics include the role of the CEO and the senior team, organizational growth and scaling, organizational culture, organizational design, and innovation. The course focuses in particular on the causes and cures for dysfunctional organizational friction, and the related question what organizations ought to make difficult or impossible to do. For juniors and seniors, with preference given to students who have taken MS&E 180.