## MCP 126: Neurons and Disease

Diseases of the nervous system. First lecture of each week focuses on the clinical, epidemiological and behavioral aspects of a selected disease or syndrome. Second lecture exposes the cell biological, electrophysiological, biochemical and/or molecular biological processes that underlie each disease presented. Instructors maintain some flexibility in the diseases chosen for elucidation, but students can expect those covered to range from the relatively straightforward, for example Multiple Sclerosis (MS) or Amyotrophic Lateral Sclerosis (ALS), to the more complex, for example, Schizophrenia or Obsessive Compulsive Disorder (OCD). Prerequisite: Biology or Human Biology core.

Last offered: Spring 2016

## MCP 156: How Cells Work: Energetics, Compartments, and Coupling in Cell Biology (MCP 256)

Open to graduate and medical students, and advanced undergraduates. Dynamic aspects of cell behavior and function, including cellular energetics, homeostasis, heterogeneity of membranes, structure and function of organelles, solute and water transport, signaling and motility. Emphasis is on the principles of how coupling of molecular processes gives rise to essential functions at the cellular level. Mathematical models of cell function. Student presentations.

Terms: Spr
| Units: 4

## MCP 199: Undergraduate Research

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

Terms: Aut, Win, Spr, Sum
| Units: 1-18
| Repeatable for credit

Instructors:
Brunger, A. (PI)
;
Chu, S. (PI)
;
Feng, L. (PI)
;
Garcia, C. (PI)
;
Goodman, M. (PI)
;
Kobilka, B. (PI)
;
Lewis, R. (PI)
;
Madison, D. (PI)
;
Maduke, M. (PI)
;
Nachury, M. (PI)
;
Nelson, W. (PI)
;
O'Brien, L. (PI)
;
Smith, S. (PI)
;
Sudhof, T. (PI)
;
Tsien, R. (PI)
;
Weis, W. (PI)

## MCP 207: MCP Bootcamp

Hands-on, week-long immersion in methods and concepts related to the physiology of cell signaling. Required of all first-year MCP students; other PhD students may enroll with consent of instructor.

Terms: Aut
| Units: 3

Instructors:
Feng, L. (PI)
;
O'Brien, L. (PI)

## MCP 221: Advanced Cell Biology (BIO 214, BIOC 224)

For Ph.D. students. Current research on cell structure, function, and dynamics. Topics include complex cell phenomena such as cell division, apoptosis, compartmentalization, transport and trafficking, motility and adhesion, and differentiation. Weekly reading of current papers from the primary literature. Preparation of an original research proposal. Prerequisite for advanced undergraduates:
BIO 129A,B, and consent of instructor.

Terms: Win
| Units: 4

Instructors:
Jonikas, M. (PI)
;
Kopito, R. (PI)
;
Pfeffer, S. (PI)
...
more instructors for MCP 221 »

Instructors:
Jonikas, M. (PI)
;
Kopito, R. (PI)
;
Pfeffer, S. (PI)
;
Rohatgi, R. (PI)
;
Theriot, J. (PI)

## MCP 256: How Cells Work: Energetics, Compartments, and Coupling in Cell Biology (MCP 156)

Open to graduate and medical students, and advanced undergraduates. Dynamic aspects of cell behavior and function, including cellular energetics, homeostasis, heterogeneity of membranes, structure and function of organelles, solute and water transport, signaling and motility. Emphasis is on the principles of how coupling of molecular processes gives rise to essential functions at the cellular level. Mathematical models of cell function. Student presentations.

Terms: Spr
| Units: 4

## MCP 287: Connectomes

(Same as
PSYCH 287) Neural circuitry can be measured over a huge range of spatial scales, from sub-synaptic to whole brain connectomes. The methods used to measure these scales differ enormously, and scientists working at one scale should be able to understand and communicate with those measuring at other scales. Reviews methods, principal results, and ideas for integrating findings across scales by large-scale computation modeling.

## MCP 299: Directed Reading in Molecular and Cellular Physiology

Prerequisite: consent of instructor.

Terms: Aut, Win, Spr, Sum
| Units: 1-18
| Repeatable for credit

Instructors:
Brunger, A. (PI)
;
Chu, S. (PI)
;
Feng, L. (PI)
;
Garcia, C. (PI)
;
Goodman, M. (PI)
;
Kobilka, B. (PI)
;
Lewis, R. (PI)
;
Madison, D. (PI)
;
Maduke, M. (PI)
;
Nachury, M. (PI)
;
Nelson, W. (PI)
;
O'Brien, L. (PI)
;
Smith, S. (PI)
;
Sudhof, T. (PI)
;
Tsien, R. (PI)
;
Weis, W. (PI)