BIOS 212: Analytical Methods in Biotechnology (EE 235, RAD 236)
This course provides fundamental principles underlying important analytical techniques used in modern biotechnology. The course comprises of lectures and hands-on laboratory experiments. Students will learn the core principles for designing, implementing and analyzing central experimental methods including polymerase chain reaction (PCR), electrophoresis, immunoassays, and high-throughput sequencing. The overall goal of the course is to enable engineering students with little or no background in molecular biology to transition into research in the field of biomedicine.
Terms: Spr
| Units: 3
Instructors:
Soh, H. (PI)
;
Stoyanova, T. (SI)
BIOS 221: Modern Statistics for Modern Biology (STATS 155, STATS 256, STATS 366)
Application based course in nonparametric statistics. Modern toolbox of visualization and statistical methods for the analysis of data, examples drawn from immunology, microbiology, cancer research and ecology. Methods covered include multivariate methods (PCA and extensions), sparse representations (trees, networks, contingency tables) as well as nonparametric testing (Bootstrap, permutation and Monte Carlo methods). Hands on, use R and cover many Bioconductor packages. Prerequisite: Working knowledge of R and two core Biology courses. Note that the 155 offering is a writing intensive course for undergraduates only and requires instructor consent. (WIM)
Terms: Spr
| Units: 3
Instructors:
Holmes, S. (PI)
BIOS 225: Diversity and Inclusion in Science
Introduction to the social science literature on factors contributing to gender disparities in the scientific workplace (e.g. implicit bias and stereotype threat). Discussions focus on steps that individuals and institutions can take to promote the advancement of women and other underrepresented groups in science, and thus promote the advancement of science.
Terms: Spr
| Units: 1
BIOS 236: Developmental Biology in the Ocean: Comparative Embryology and Larval Development
Three-week course at Hopkins Marine Station. Focuses on the embryology and larval development of a broad range of marine invertebrate phyla. The goal of the course is to give students an appreciation of the range of developmental strategies and larval forms in the ocean and why this is critical for constructing hypotheses of EvoDevo and animal evolution. Includes observation and documentation of the development of embryos and larvae by scientific illustration and photo/video microscopy. Pre-requisite: Developmental Biology coursework and instructor consent.
Terms: Spr
| Units: 4
BIOS 263: Applied Grant-Writing Skills for Fellowships
Graduate students in the Biosciences PhD Programs develop a fellowship proposal (e.g. NIH F31) focusing on required documents: 1-page specific aims as well as research and career development plans. Students establish a writing practice and learn fundamental grant writing skills through guided exercises, including in-class review and focused faculty feedback.
Terms: Spr
| Units: 2
| Repeatable
10 times
(up to 20 units total)
BIOS 268: Biology and Applications of CRISPR/Cas9: Genome Editing and Epigenome Modifications (GENE 268)
This course is designed to provide a broad overview of the biology and applications of the revolutionary CRISPR/Cas9 system, with detailed exploration of several areas: / / --Basic biology of the CRISPR/Cas9 system / --High-throughput screening using CRISPR/Cas9 / --Epigenetic modifications and transcriptional regulation using dCas9 / --Therapeutic applications of gene editing with CRISPR / --Disease modeling with CRISPR / --Ethical considerations of the use of CRISPR/Cas9 / / The course will be geared toward advanced undergraduates and graduate students, and will assume a basic background in molecular biology and genetics. The course will be lecture-based, with frequent opportunities for discussion and questions.
Terms: Spr
| Units: 1
Instructors:
Bassik, M. (PI)
;
Carette, J. (SI)
;
Cho, M. (SI)
;
Greely, H. (SI)
;
Ormond, K. (SI)
;
Porteus, M. (SI)
;
Qi, S. (SI)
;
Winslow, M. (SI)
BIOS 285: Rodent Animal Models: Selection, Detection, Dissection, Inspection
This 2-week mini-course will discuss pragmatic approaches to rodent utilization with the aim of empowering graduate students across multiple disciplines to maximize rodent-derived data and minimize the redundant use of animals in biomedical research. Topics will include an introduction to clinical models, practical aspects of rodent blood collection and interpretation, algorithmic approaches to tissue collection for research applications, and an introduction to rodent histopathology, immunohistochemistry, and immunofluorescence. Course instructors include board-certified laboratory animal medicine clinicians and comparative pathologists that are expert h these topics. This course is open to graduate students with or without prior rodent experience.
Terms: Spr
| Units: 1
BIOS 291: Preparation & Practice: Management Consulting
This course is designed for students who are interested in learning about consulting including tools and techniques to gain a consulting mindset. The course requires students to complete short assignments, participate in classroom discussions, and a team project. Students will have the opportunity to understand the consulting process right from sourcing and starting engagements to closure and follow up engagements. Further, with the help of some practical execution in the classroom, students will also learn how to manage client needs and situations, articulating client needs in a succinct proposal, planning and executing consulting assignments, managing client interactions and in the process, learn to leverage some common frameworks for consulting.
Terms: Spr
| Units: 1
BIOS 296: Preparation & Practice: Biotechnology Business
This course combines guest lectures with case study and hands-on projects to examine the necessary skills and practical steps necessary to create a business from biotechnology invention. Students will interface with current C-level executives and expert practitioners to gain practical insight into the business mechanics and practices of the biotechnology industry, and the variety of roles and responsibilities available to them.
Terms: Spr
| Units: 1
BIOS 297: COVID-19 Pandemic: Lessons Learned
The Covid-19 pandemic has created unprecedented challenges for individuals, society, medicine and science. The SARS-Cov-2 virus rapidly disseminated since first reports from China on December 31, 2019 and by March 11, 2020 it was declared a global pandemicby the World Health Organization. This course will cover various aspects of Covid-19 including clinical perspectives, public health response, impact of disease modeling, and results of clinical trials and research efforts. As the pandemic evolves the course will discuss the most current data and reflect on successes and ongoing challenges as the world grapples with a pandemic of unmatched proportions.
Terms: Aut, Spr
| Units: 1
Instructors:
Jagannathan, P. (PI)
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