## BIODS 48N: Riding the Data Wave (STATS 48N)

Imagine collecting a bit of your saliva and sending it in to one of the personalized genomics company: for very little money you will get back information about hundreds of thousands of variable sites in your genome. Records of exposure to a variety of chemicals in the areas you have lived are only a few clicks away on the web; as are thousands of studies and informal reports on the effects of different diets, to which you can compare your own. What does this all mean for you? Never before in history humans have recorded so much information about themselves and the world that surrounds them. Nor has this data been so readily available to the lay person. Expression as "data deluge'' are used to describe such wealth as well as the loss of proper bearings that it often generates. How to summarize all this information in a useful way? How to boil down millions of numbers to just a meaningful few? How to convey the gist of the story in a picture without misleading oversimplifications? To an
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Imagine collecting a bit of your saliva and sending it in to one of the personalized genomics company: for very little money you will get back information about hundreds of thousands of variable sites in your genome. Records of exposure to a variety of chemicals in the areas you have lived are only a few clicks away on the web; as are thousands of studies and informal reports on the effects of different diets, to which you can compare your own. What does this all mean for you? Never before in history humans have recorded so much information about themselves and the world that surrounds them. Nor has this data been so readily available to the lay person. Expression as "data deluge'' are used to describe such wealth as well as the loss of proper bearings that it often generates. How to summarize all this information in a useful way? How to boil down millions of numbers to just a meaningful few? How to convey the gist of the story in a picture without misleading oversimplifications? To answer these questions we need to consider the use of the data, appreciate the diversity that they represent, and understand how people instinctively interpret numbers and pictures. During each week, we will consider a different data set to be summarized with a different goal. We will review analysis of similar problems carried out in the past and explore if and how the same tools can be useful today. We will pay attention to contemporary media (newspapers, blogs, etc.) to identify settings similar to the ones we are examining and critique the displays and summaries there documented. Taking an experimental approach, we will evaluate the effectiveness of different data summaries in conveying the desired information by testing them on subsets of the enrolled students.

Terms: Aut
| Units: 3
| UG Reqs: WAY-AQR, WAY-FR

Instructors:
Sabatti, C. (PI)

## BIOE 80: Introduction to Bioengineering (Engineering Living Matter) (ENGR 80)

Students completing BIOE.80 should have a working understanding for how to approach the systematic engineering of living systems to benefit all people and the planet. Our main goals are (1) to help students learn ways of thinking about engineering living matter and (2) to empower students to explore the broader ramifications of engineering life. Specific concepts and skills covered include but are not limited to: capacities of natural life on Earth; scope of the existing human-directed bioeconomy; deconstructing complicated problems; reaction & diffusion systems; microbial human anatomy; conceptualizing the engineering of biology; how atoms can be organized to make molecules; how to print DNA from scratch; programming genetic sensors, logic, & actuators; biology beyond molecules (photons, electrons, etc.); what constraints limit what life can do?; what will be the major health challenges in 2030?; how does what we want shape bioengineering?; who should choose and realize various competing bioengineering futures?

Terms: Spr
| Units: 4
| UG Reqs: GER:DB-EngrAppSci, WAY-FR

## BIOHOPK 174H: Experimental Design and Probability (BIOHOPK 274H)

(Graduate students register for 274H.) Variability is an integral part of biology. Introduction to probability and its use in designing experiments to address biological problems. Focus is on experimental design and the use of linear models in testing hypotheses (e.g., analysis of variance, regression). Students will use R to explore and analyze locally relevant biological datasets. No programming or statistical background is assumed. Prerequisite: consent of instructor.

Terms: Spr
| Units: 3
| UG Reqs: GER: DB-NatSci, GER:DB-Math, WAY-AQR, WAY-FR

Instructors:
Elahi, R. (PI)

## BIOHOPK 177H: Dynamics and Management of Marine Populations (BIOHOPK 277H)

(Graduate students register for 277H.) Course examines the ecological factors and processes that control natural and harvested marine populations. Course emphasizes mathematical models as tools to assess the dynamics of populations and to derive projections of their demographic fate under different management scenarios. Course objectives will be met by a combination of theoretical lectures, assigned readings and class discussions, case study analysis and interactive computer sessions.

Last offered: Winter 2018
| UG Reqs: WAY-AQR, WAY-FR
| Repeatable for credit

## CME 100: Vector Calculus for Engineers (ENGR 154)

Computation and visualization using MATLAB. Differential vector calculus: analytic geometry in space, functions of several variables, partial derivatives, gradient, unconstrained maxima and minima, Lagrange multipliers. Introduction to linear algebra: matrix operations, systems of algebraic equations, methods of solution and applications. Integral vector calculus: multiple integrals in Cartesian, cylindrical, and spherical coordinates, line integrals, scalar potential, surface integrals, Green's, divergence, and Stokes' theorems. Examples and applications drawn from various engineering fields. Prerequisites: knowledge of single-variable calculus equivalent to the content of
Math 19-21 (e.g., 5 on Calc BC, 4 on Calc BC with
Math 21, 5 on Calc AB with
Math21). Placement diagnostic (recommendation non binding) at:(
https://exploredegrees.stanford.edu/undergraduatedegreesandprograms/#aptext).

Terms: Aut, Spr
| Units: 5
| UG Reqs: GER:DB-Math, WAY-FR

Instructors:
Khayms, V. (PI)
;
Le, H. (PI)

## CME 100A: Vector Calculus for Engineers, ACE

Students attend
CME100/ENGR154 lectures with additional recitation sessions; two to four hours per week, emphasizing engineering mathematical applications and collaboration methods. Enrollment by department permission only. Prerequisite: must be enrolled in the regular
CME100-01 or 02. Application at:
https://engineering.stanford.edu/students/programs/engineering-diversity-programs/additional-calculus-engineers

Terms: Aut, Spr
| Units: 6
| UG Reqs: GER:DB-Math, WAY-FR

Instructors:
Khayms, V. (PI)
;
Le, H. (PI)

## CME 102: Ordinary Differential Equations for Engineers (ENGR 155A)

Analytical and numerical methods for solving ordinary differential equations arising in engineering applications: Solution of initial and boundary value problems, series solutions, Laplace transforms, and nonlinear equations; numerical methods for solving ordinary differential equations, accuracy of numerical methods, linear stability theory, finite differences. Introduction to MATLAB programming as a basic tool kit for computations. Problems from various engineering fields.Prerequisites: knowledge of single-variable calculus equivalent to the content of
Math 19-21 (e.g., 5 on Calc BC, 4 on Calc BC with
Math 21, 5 on Calc AB with
Math21). Placement diagnostic (recommendation non binding) at:(
https://exploredegrees.stanford.edu/undergraduatedegreesandprograms/#aptext). Recommended:
CME100.

Terms: Aut, Win, Spr, Sum
| Units: 5
| UG Reqs: GER:DB-Math, WAY-FR

Instructors:
Le, H. (PI)

## CME 102A: Ordinary Differential Equations for Engineers, ACE

Students attend
CME102/ENGR155A lectures with additional recitation sessions; two to four hours per week, emphasizing engineering mathematical applications and collaboration methods. Prerequisite: students must be enrolled in the regular section (
CME102) prior to submitting application at:n
https://engineering.stanford.edu/students/programs/engineering-diversity-programs/additional-calculus-engineers

Terms: Aut, Win, Spr
| Units: 6
| UG Reqs: GER:DB-Math, WAY-FR

Instructors:
Le, H. (PI)

## CME 103: Introduction to Matrix Methods (EE 103)

Introduction to applied linear algebra with emphasis on applications. Vectors, norm, and angle; linear independence and orthonormal sets; applications to document analysis. Clustering and the k-means algorithm. Matrices, left and right inverses, QR factorization. Least-squares and model fitting, regularization and cross-validation. Constrained and nonlinear least-squares. Applications include time-series prediction, tomography, optimal control, and portfolio optimization. Undergraduate students should enroll for 5 units, and graduate students should enroll for 3 units. Prerequisites:
MATH 51 or
CME 100, and basic knowledge of computing (
CS 106A is more than enough, and can be taken concurrently).
EE103/CME103 and
Math 104 cover complementary topics in applied linear algebra. The focus of EE103 is on a few linear algebra concepts, and many applications; the focus of
Math 104 is on algorithms and concepts.

Terms: Aut, Win, Sum
| Units: 3-5
| UG Reqs: GER:DB-Math, WAY-AQR, WAY-FR

## CME 104: Linear Algebra and Partial Differential Equations for Engineers (ENGR 155B)

Linear algebra: matrix operations, systems of algebraic equations, Gaussian elimination, undetermined and overdetermined systems, coupled systems of ordinary differential equations, eigensystem analysis, normal modes. Fourier series with applications, partial differential equations arising in science and engineering, analytical solutions of partial differential equations. Numerical methods for solution of partial differential equations: iterative techniques, stability and convergence, time advancement, implicit methods, von Neumann stability analysis. Examples and applications from various engineering fields. Prerequisite:
CME 102/
ENGR 155A.

Terms: Spr
| Units: 5
| UG Reqs: GER:DB-Math, WAY-FR

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