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99.9% of all species that have ever inhabited Earth are now extinct, including 12 species of the genus Homo. The threat of human extinction is global, and it is driven by social, economic, technological and political forces operating at global scales. This course will explore several plausible scenarios by which human extinction (or near-extinction) could occur within the next 100 years. In this course, we will study the psychological, social, political, economic and epistemological barriers that frequently derail efforts to avert these catastrophes. We will explore diverse approaches to understanding these risks, strategies that could reduce them, and better ways to think and act as we move into an uncertain future. Students will engage these issues through academic reading, apocalyptic fiction, group discussion and writing. We will consider the role of human agency in the evolution of these risks and their prevention, and our responsibilities as 21st-century citizens.