1 - 7 of 7 results for: BIOS

Usher in the golden age of biological discovery with next generation sequencing (NGS) through its wide spectrum of applications. Modules include general introduction of Next Generation Sequencing (NGS) technologies, applications of these sequencing technologies, caveats and comparisons with previous approaches, analysis and interpretation of sequencing data, principles of tools and resources and practical ways to utilize them, and features and pitfalls. Prerequisite: background in molecular biology.

Introduction to the social science literature on factors contributing to gender disparities in the scientific workplace (e.g. implicit bias and stereotype threat). Discussions focus on steps that individuals and institutions can take to promote the advancement of women and other underrepresented groups in science, and thus promote the advancement of science.

Mini-course. Students will use learn make and print 3D models of their data to use as a focal point when describing their project. We will teach the students how to use Autocad and Blender to process existing data sets and students are encouraged to bring their own data. We strive to make wearable models to enable instant mini-lectures any place and anytime.

This course will introduce two lung diseases, pulmonary hypertension and emphysema, and uses them as a forum to discuss how modern molecular and cellular analysis tools can offer novel insights into the mechanisms through which diseases arise. We will discuss the histological and molecular processes underlying these diseases, and how modern techniques and approaches such as progenitor cell identification and lineage tracing, single cell RNA sequencing, deep tissue imaging, and cell type-specific mutation and misexpression can be employed to bring novel insights into their pathobiology and thereby offer potential opportunities to influence the course of these diseases. /

The organogenesis of the human central nervous system is an intricately orchestrated series of events that occurs over several months and ultimately gives rise to the circuits underlying cognition and behavior. There is a pressing need for developing reliable, realistic, and personalized in vitro models of the human brain to advance our understanding of neural development, evolution, and disease. Pluripotent stem cells have the remarkable ability to differentiate in vitro into any of the germ layers and, with the advent of three-dimensional (3D) cell culture methods, to self-organize into brain spheroids or organoids. These organoid cultures can be derived from any individual, can be guided to resemble specific brain regions, and can be employed to model complex cell-cell interactions and to build human circuits in vitro. This course will cover in detail the principles of human brain organogenesis in vivo and compare them to in vitro modeling using recently developed organoid and assembloid technologies.

The goal of our workshop course will be to introduce students in the biomedical sciences to the basic quantitative tools of statistical physics and theoretical ecology that can be used to describe changing spatial patterns and collective movement in cell systems. Recent advances in imaging have led to new research questions on collective movement and spatial pattern in cells. We will work with data from current student research projects, to apply quantitative methods that have been developed for similar processes at other scales, including particles and whole organisms.