BIOE 238: Principles and Tools for Metrology in Biology
A practical introduction to the science of measurement. Emphasis is on the tools used to parse a biological measurement problem. Students will learn to identify and quantitatively address the critical sources of variability and bias using the core concepts of uncertainty, traceability, and validation. Case studies will illustrate use of metrology in current and emergent bioscience and engineering applications.
Last offered: Spring 2018
BIOE 240: Principles of Synthetic Biology
Synthetic biology is the fundamental science and engineering research that advances building with biology. The key idea is to make biology easier to engineer, which enables biology as a general use technology to make what is needed, where and when it is needed, on a sustainable and renewable basis. From just-add-water biotechnology to cellular therapies to distributed diagnostics for human and environmental health to transforming pollution into materials we use every day, synthetic biology holds promise to allow us to rethink how we meet human needs on a planetary scale. In this course, the field of synthetic biology and its natural scientific and engineering basis are introduced and discussed.
Terms: Aut
| Units: 3
BIOE 241: Biological Macromolecules (BIOC 241, BIOPHYS 241, SBIO 241)
The physical and chemical basis of macromolecular function. Topics include: forces that stabilize macromolecular structure and their complexes; thermodynamics and statistical mechanics of macromolecular folding, binding, and allostery; diffusional processes; kinetics of enzymatic processes; the relationship of these principles to practical application in experimental design and interpretation. The class emphasizes interactive learning, and is divided among lectures, in-class group problem solving, and discussion of current and classical literature. Enrollment limited to 30. Prerequisites: Background in biochemistry and physical chemistry recommended but material available for those with deficiency in these areas; undergraduates with consent of instructor only.
Terms: Aut
| Units: 3-5
BIOE 244: Advanced Frameworks and Approaches for Engineering Integrated Genetic Systems
Concepts and techniques for the design and implementation of engineered genetic systems. Topics covered include the quantitative exploration of tools that support (a) molecular component engineering, (b) abstraction and composition of functional genetic devices, (c) use of control and dynamical systems theory in device and systems design, (d) treatment of molecular "noise", (e) integration of DNA-encoded programs within cellular chassis, (f) designing for evolution, and (g) the use of standards in measurement, genetic layout architecture, and data exchange. Prerequisites:
CME104,
CME106,
CHEM 33,
BIO41,
BIO42,
BIOE41,
BIOE42, and
BIOE44 (or equivalents), or permission of the instructors.
Last offered: Spring 2019
BIOE 256: Technology Assessment and Regulation of Medical Devices (MS&E 256)
Regulatory approval and reimbursement for new health technologies are critical success factors for product commercialization. This course explores the regulatory and payer environment in the U.S. and abroad, as well as common methods of health technology assessment. Students will learn frameworks to identify factors relevant to the adoption of new health technologies, and the management of those factors in the design and development phases of bringing a product to market through case studies, guest speakers from government (FDA) and industry, and a course project.
Terms: Spr
| Units: 3
BIOE 260: Tissue Engineering (ORTHO 260)
Principles of tissue engineering and design strategies for practical applications for tissue repair. Topics include tissue morphogenesis, stem cells, biomaterials, controlled drug and gene delivery, and paper discussions. Students will learn skills for lab research through interactive lectures, paper discussions and research proposal development. Students work in small teams to work on develop research proposal for authentic tissue engineering problems. Lab sessions will teach techniques for culturing cells in 3D, as well as fabricating and characterizing hydrogels as 3D cell niche.
Terms: Spr
| Units: 4
BIOE 261: 3D Bioprinting Laboratory
3D bioprinting promises engineered tissues with precise structure, composition, and cellular architecture. This biofabrication technology lies at the interface of biology, bioengineering, materials science, and instrumentation. This course will teach some of the latest technologies through fundamental lectures and hands-on 3D bioprinting workshops. Student groups will embark on independent projects to innovate in any aspect or application of 3D bioprinting hardware, wetware, or software. Experience in tissue engineering (
BIOE260), instrumentation (
BIOE123), or biomaterials (
MATSCI 381) is helpful but not required.
Terms: Win
| Units: 4
BIOE 269: Comparative Single-cell Genomics in the Ocean (BIO 269)
The goal of the course is to provide students with hands-on experience in applying single-cell sequencing technology to examine marine animals with cellular resolution, both at the bench and on computers. Throughout the course, students learn how to collect animals, dissect and dissociate tissues, generate single-cell sequencing libraries, process and analyze their own data, and compare cell types across animals using the computational pipelines. This pipeline is optimized to study organisms without extensive prior knowledge and provides students with a valuable set of tools for future work in this field. This course uses a diverse set of animals in order to study the conservation and divergence of cell types and their gene regulatory programs across the animal kingdom. The course includes lectures on Mondays, and web and dry lab components, which have flexible schedules. Pre-requite:
BioE219 (recommended for engineering students) or instructor consent.
Last offered: Summer 2023
BIOE 271: Frugal Science
As a society, we find ourselves surrounded by planetary-scale challenges ranging from lack of equitable access to health care to environmental degradation to dramatic loss of biodiversity. One common theme that runs across these challenges is the need to invent cost-effective solutions with the potential to scale. The COVID-19 pandemic provides yet another example of such a need. In this course, participants will learn principles of frugal science to design scalable solutions with a cost versus performance rubric and explore creative means to break the accessibility barrier. Using historic and current examples, we will emphasize the importance of first-principles science to tackle design challenges with everyday building blocks. Enrollment is open to all Stanford students from all schools/majors, who will team up with collaborators from across the globe to build concrete solutions to planetary-scale challenges. Come learn how to solve serious challenges with a little bit of play.
Terms: Win
| Units: 4
BIOE 273: Biodesign for Digital Health (MED 273)
Health care is facing significant cross-industry challenges and opportunities created by a number of factors, including the increasing need for improved access to affordable, high-quality care; growing demand from consumers for greater control of their health and health data; the shift in focus from sick care to prevention and health optimization; aging demographics and the increased burden of chronic conditions; and new emphasis on real-world, measurable health outcomes for individuals and populations. Moreover, the delivery of health information and services is no longer tied to traditional brick and mortar hospitals and clinics: it has increasingly become "mobile," enabled by apps, sensors, wearables. Simultaneously, it has been augmented and often revolutionized by emerging digital and information technologies, as well as by the data that these technologies generate. This multifactorial transformation presents opportunities for innovation across the entire cycle of care, from welln
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Health care is facing significant cross-industry challenges and opportunities created by a number of factors, including the increasing need for improved access to affordable, high-quality care; growing demand from consumers for greater control of their health and health data; the shift in focus from sick care to prevention and health optimization; aging demographics and the increased burden of chronic conditions; and new emphasis on real-world, measurable health outcomes for individuals and populations. Moreover, the delivery of health information and services is no longer tied to traditional brick and mortar hospitals and clinics: it has increasingly become "mobile," enabled by apps, sensors, wearables. Simultaneously, it has been augmented and often revolutionized by emerging digital and information technologies, as well as by the data that these technologies generate. This multifactorial transformation presents opportunities for innovation across the entire cycle of care, from wellness, to acute and chronic diseases, to care at the end of life. But how does one approach innovation in digital health to address these health care challenges while ensuring the greatest chance of success? At Stanford Biodesign, we believe that innovation is a process that can be learned, practiced, and perfected; and, it starts with an unmet need. In Biodesign for Digital Health, students will learn about digital health and the Biodesign needs-driven innovation process from over 50 industry experts. Over the course of 10weeks, these speakers will join the teaching team in a dynamic classroom environment that includes lectures, panel discussions, and breakout sessions. These experts represent startups, corporations, venture capital firms, accelerators, research labs, healthcare providers, and more. Student teams will take actual digital and mobile health challenges and learn how to apply Biodesign innovation principles to research and evaluate needs, ideate solutions, and objectively assess them against key criteria for satisfying the needs. Teams take a hands-on approach with the support of need coaches and other mentors. On the final day of class, teams present to a panel of digital health experts and compete for project extension funding. Friday section will be used for team projects and for scheduled workshops. Limited enrollment for this course. Students should submit their application online via:
https://stanforduniversity.qualtrics.com/jfe/form/SV_dnY6nvUXMYeILkO
Terms: Aut
| Units: 3-4
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