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(Only one of 173 or 273A counts toward any CS degree program.) Introduction to computational biology through an informatic exploration of the human genome. Topics include: genome sequencing; functional landscape of the human genome (genes, gene regulation, repeats, RNA genes, epigenetics); genome evolution (comparative genomics, ultraconservation, co-option). Additional topics may include population genetics, personalized genomics, and ancient DNA. Course includes primers on molecular biology, the UCSC Genome Browser, and text processing languages. Guest lectures on current genomic research topics. Class will be similar in spirit to CS273A, which will not be offered this year. Prerequisites: CS107 or equivalent background in programming.