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Methods for analyzing longitudinal data. Topics include Kaplan-Meier methods, Cox regression, hazard ratios, time-dependent variables, longitudinal data structures, profile plots, missing data, modeling change, MANOVA, repeated-measures ANOVA, GEE, and mixed models. Emphasis is on practical applications. Prerequisites: basic ANOVA and linear regression.

The course will consist of readings and discussion of foundational papers and book sections in the domains of statistical and scientific inference. Topics to be covered include philosophy of science, interpretations of probability, Bayesian and frequentist approaches to statistical inference and current controversies about the proper use of p-values and research reproducibility. Recommended preparation: At least 2 quarters of biostatistics and one of epidemiology. Intended for second year Masters students or PhD students with at least 1 year of preceding graduate training.

This course will treat Bayesian statistics at a relatively advanced level. Assuming familiarity with standard probability and multivariate distribution theory, we will provide a discussion of the mathematical and theoretical foundation for Bayesian inferential procedures. In particular, we will examine the construction of priors and the asymptotic properties of likelihoods and posterior distributions. The discussion will include but will not be limited to the case of finite dimensional parameter space. There will also be some discussions on the computational algorithms useful for Bayesian inference. Prerequisites: Stats 116 or equivalent probability course, plus basic programming knowledge; basic calculus, analysis and linear algebra strongly recommended; Stats 200 or equivalent statistical theory course desirable.

Ambitious Data Science requires massive computational experimentation; the entry ticket for a solid PhD in some fields is now to conduct experiments involving 1 Million CPU hours. Recently several groups have created efficient computational environments that make it painless to run such massive experiments. This course reviews state-of-the-art practices for doing massive computational experiments on compute clusters in a painless and reproducible manner. Students will learn how to automate their computing experiments first of all using nuts-and-bolts tools such as Perl and Bash, and later using available comprehensive frameworks such as ClusterJob and CodaLab, which enables them to take on ambitious Data Science projects. The course also features few guest lectures by renowned scientists in the field of Data Science. Students should have a familiarity with computational experiments and be facile in some high-level computer language such as R, Matlab, or Python.

Masters-level research as in 299, but with the approval and supervision of a faculty adviser, it must be conducted for an off-campus employer. Students must submit a written final report upon completion of the internship in order to receive credit. Repeatable for credit. Prerequisite: enrollment in Statistics M.S. program. IMPORTANT: F-1 international students enrolled in this CPT course cannot start working without first obtaining a CPT-endorsed I-20 from Bechtel International Center (enrolling in the CPT course alone is insufficient to meet federal immigration regulations).

For Statistics M.S. students only. Reading or research program under the supervision of a Statistics faculty member. May be repeated for credit.

Finite sample optimality of statistical procedures; Decision theory: loss, risk, admissibility; Principles of data reduction: sufficiency, ancillarity, completeness; Statistical models: exponential families, group families, nonparametric families; Point estimation: optimal unbiased and equivariant estimation, Bayes estimation, minimax estimation; Hypothesis testing and confidence intervals: uniformly most powerful tests, uniformly most accurate confidence intervals, optimal unbiased and invariant tests. Prerequisites: Real analysis, introductory probability (at the level of STATS 116), and introductory statistics.

Elementary decision theory; loss and risk functions, Bayes estimation; UMVU estimator, minimax estimators, shrinkage estimators. Hypothesis testing and confidence intervals: Neyman-Pearson theory; UMP tests and uniformly most accurate confidence intervals; use of unbiasedness and invariance to eliminate nuisance parameters. Large sample theory: basic convergence concepts; robustness; efficiency; contiguity, locally asymptotically normal experiments; convolution theorem; asymptotically UMP and maximin tests. Asymptotic theory of likelihood ratio and score tests. Rank permutation and randomization tests; jackknife, bootstrap, subsampling and other resampling methods. Further topics: sequential analysis, optimal experimental design, empirical processes with applications to statistics, Edgeworth expansions, density estimation, time series.

Decision theory formulation of statistical problems. Minimax, admissible procedures. Complete class theorems ("all" minimax or admissible procedures are "Bayes"), Bayes procedures, conjugate priors, hierarchical models. Bayesian non parametrics: diaichlet, tail free, polya trees, bayesian sieves. Inconsistency of bayes rules.