printer friendly pageBIOC 109B: Advances in Therapeutic Development: Neuronal Signaling and Immunology (BIO 109B)
This is a seminar course focused on teaching students about novel research and applications in the fields of neuroscience and immunology. The course will cover topics that range from the neuronal pathways in opioid addiction and the mechanics of pain, to advances in immunotherapy. Students will engage with diverse material from leading neuroscience and cancer immunotherapy experts in the Bay Area. Guest lecturers will visit from both academia and neighboring pharmaceutical/biotechnology companies. Active participation is required. Prerequisite: Biology or Human Biology core. Students with a major, minor or coterm in Biology: 109A/209A or 109B/209B may count toward degree program, but not both.
Terms: Spr
| Units: 3
| UG Reqs: GER: DB-NatSci, WAY-SMA
BIOE 42: Physical Biology
BIOE 42 is designed to introduce students to general engineering principles that have emerged from theory and experiments in biology. Topics covered will cover the scales from molecules to cells to organisms, including fundamental principles of entropy, diffusion, and continuum mechanics. These topics will link to several biological questions, including DNA organization, ligand binding, cytoskeletal mechanics, and the electromagnetic origin of nerve impulses. In all cases, students will learn to develop toy models that can explain quantitative measurements of the function of biological systems. Prerequisites:
MATH 19, 20, 21
CHEM 31A, B (or 31X),
PHYSICS 41; strongly recommended:
CS 106A,
CME 100 or
MATH 51, and
CME 106; or instructor approval.
Terms: Spr
| Units: 4
| UG Reqs: WAY-AQR, WAY-SMA
Instructors:
Bryant, Z. (PI)
;
Huang, K. (PI)
;
Meany, E. (TA)
;
Nguyen, T. (TA)
;
Starr, C. (TA)
;
Sun, J. (TA)
BIOE 44: Fundamentals for Engineering Biology Lab
An introduction to next-generation techniques in genetic, molecular, biochemical, and cellular engineering. Lectures cover advances in the field of synthetic biology with emphasis on genetic engineering, CRISPR gene editing technology, the DIY bio movement, plasmid design, gene synthesis, genetic circuits, safety and bio ethics. At-home lab modules will teach students how to isolate DNA from living matter, make genetic alterations by plasmid transformations and introduce students to experimental design. During the final weeks of the course students work in groups to design a DNA device. Group projects will build upon current research including: gene and genome engineering via decoupled design, component engineering with a focus on molecular design and quantitative analysis of experiments, device and system engineering using abstracted genetically encoded objects, and product development based on useful applications of biological technologies. Concurrent or previous enrollment in
BIO 82 or
BIO 83.
Terms: Aut, Win
| Units: 4
| UG Reqs: WAY-SMA
Instructors:
Love, Z. (PI)
;
Qi, S. (PI)
;
Wang, B. (PI)
;
Atsavapranee, B. (TA)
;
Hays, M. (TA)
;
Monette, C. (TA)
;
Valverde Rambaud, V. (TA)
;
Xu, J. (TA)
BIOE 72N: Pathophysiology and Design for Cardiovascular Disease
Future physicians, social and biological scientists, and engineers will be the core of teams that solve major problems threatening human health. Bridging these diverse areas will require thinkers who can understand human biology and also think broadly about approaching such challenges.nnFocusing on heart disease, students in this seminar will learn about the multi-factorial problems leading to the leading cause of death in the U.S., along with how to apply design thinking to innovate in the context of healthcare.
Terms: Sum
| Units: 3
| UG Reqs: WAY-SMA
Instructors:
Venook, R. (PI)
;
Wang, P. (PI)
BIOE 102: Physical Biology of Macromolecules
Principles of statistical physics, thermodynamics, and kinetics with applications to molecular biology. Topics include entropy, temperature, chemical forces, enzyme kinetics, free energy and its uses, self assembly, cooperative transitions in macromolecules, molecular machines, feedback, and accurate replication. Prerequisites:
MATH 19, 20, 21;
CHEM 31A, B (or 31X); strongly recommended:
PHYSICS 41,
CME 100 or
MATH 51, and
CME 106; or instructor approval.
Last offered: Winter 2019
| UG Reqs: WAY-AQR, WAY-SMA
BIOE 103: Systems Physiology and Design
Physiology of intact human tissues, organs, and organ systems in health and disease, and bioengineering tools used (or needed) to probe and model these physiological systems. Topics: Clinical physiology, network physiology and system design/plasticity, diseases and interventions (major syndromes, simulation, and treatment, instrumentation for intervention, stimulation, diagnosis, and prevention), and new technologies including tissue engineering and optogenetics. Discussions of pathology of these systems in a clinical-case based format, with a view towards identifying unmet clinical needs. Learning computational skills that not only enable simulation of these systems but also apply more broadly to biomedical data analysis. Prerequisites:
CME 102;
PHYSICS 41;
BIO 82,
BIO 84.
Terms: Spr
| Units: 4
| UG Reqs: WAY-SMA, WAY-AQR
Instructors:
Deisseroth, K. (PI)
;
Fischbach, M. (PI)
;
Love, Z. (PI)
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more instructors for BIOE 103 »
Instructors:
Deisseroth, K. (PI)
;
Fischbach, M. (PI)
;
Love, Z. (PI)
;
Ke, Y. (TA)
;
Liu, F. (TA)
;
Mantri Garimella, S. (TA)
;
Shu, J. (TA)
BIOE 103B: Systems Physiology and Design
*ONLINE Offering of
BIOE 103. This pilot class,
BIOE103B, is an entirely online offering with the same content, learning goals, and prerequisites as
BIOE 103. Students attend class by watching videos and completing assignments remotely. Students may attend recitation and office hours in person, but cannot attend the BIOE103 in-person lecture due to room capacity restraints.* Physiology of intact human tissues, organs, and organ systems in health and disease, and bioengineering tools used (or needed) to probe and model these physiological systems. Topics: Clinical physiology, network physiology and system design/plasticity, diseases and interventions (major syndromes, simulation, and treatment, instrumentation for intervention, stimulation, diagnosis, and prevention), and new technologies including tissue engineering and optogenetics. Discussions of pathology of these systems in a clinical-case based format, with a view towards identifying unmet clinical needs. Learning computational skills that not only enable simulation of these systems but also apply more broadly to biomedical data analysis. Prerequisites:
CME 102;
PHYSICS 41;
BIO 82,
BIO 84. strongly recommended
PHYSICS 43. Enrollment with Instructor approval
Last offered: Spring 2020
| UG Reqs: WAY-AQR, WAY-SMA
BIOE 123: Bioengineering Systems Prototyping Lab
The Bioengineering System Prototyping Laboratory is a fast-paced, team-based system engineering experience, in which teams of 2-3 students design and build a fermenter that meets a set of common requirements along with a set of unique team-determined requirements. Students learn-by-doing hands-on skills in electronics and mechanical design and fabrication. Teams also develop process skills and an engineering mindset by aligning specifications with requirements, developing output metrics and measuring performance, and creating project proposals and plans. The course culminates in demonstration of a fully functioning fermenter that meets the teams' self-determined metrics. n nLearning goals: 1) Design, fabricate, integrate, and characterize practical electronic and mechanical hardware systems that meet clear requirements in the context of Bioengineering (i.e., build something that works). 2) Use prototyping tools, techniques, and instruments, including: CAD, 3D printing, laser cutting, microcontrollers, and oscilloscopes. 3) Create quantitative system specifications and test measurement plans to demonstrate that a design meets user requirements. 4) Communicate design elements, choices, specifications, and performance through design reviews and written reports. 5) Collaborate as a team member on a complex system design project (e.g., a fermenter). n nLimited enrollment, with priority for Bioengineering undergraduates. Prerequisites:
Physics 43, or equivalent. Experience with Matlab and/or Python is recommended.
Terms: Win
| Units: 4
| UG Reqs: WAY-SMA
BIOE 158: Soft Matter in Biomedical Devices, Microelectronics, and Everyday Life (MATSCI 158)
The relationships between molecular structure, morphology, and the unique physical, chemical, and mechanical behavior of polymers and other types of soft matter are discussed. Topics include methods for preparing synthetic polymers and examination of how enthalpy and entropy determine conformation, solubility, mechanical behavior, microphase separation, crystallinity, glass transitions, elasticity, and linear viscoelasticity. Case studies covering polymers in biomedical devices and microelectronics will be covered. Recommended:
ENGR 50 and
Chem 31A or equivalent.
Last offered: Winter 2020
| UG Reqs: WAY-AQR, WAY-SMA
BIOHOPK 14: Bio-logging and Bio-telemetry
Bio-logging is a rapidly growing discipline that includes diverse fields such as consumer electronics, medicine, and marine biology. The use of animal-attached digital tags is a powerful approach to study the movement and ecology of individuals over a wide range of temporal and spatial scales. This course is an introduction to bio-logging methods and analysis. Using whales as a model system, students will learn how use multi-sensor tags to study behavioral biomechanics.
Last offered: Spring 2018
| UG Reqs: WAY-AQR, WAY-SMA
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