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GENE 204: Essentials of Multidimensional Flow Cytometry

Keep pace with automated flow cytometry data analysis via hands-on training. Learn how to design multicolor flow cytometry experiments. Elements of quantitative flow cytometry. Course for all students, staff and faculty. Prerequisite is background in topic.
Terms: not given this year | Units: 1 | Repeatable for credit | Grading: Medical Satisfactory/No Credit

GENE 208: Gut Microbiota in Health and Disease (BIOE 221G, MI 221)

Preference to graduate students. Focus is on the human gut microbiota. Students enrolling for 3 units receive instruction on computational approaches to analyze microbiome data and must complete a related project.
Terms: Spr | Units: 2-3 | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 212: Introduction to Biomedical Informatics Research Methodology (BIOE 212, BIOMEDIN 212, CS 272)

Capstone Biomedical Informatics (BMI) experience. Hands-on software building. Student teams conceive, design, specify, implement, evaluate, and report on a software project in the domain of biomedicine. Creating written proposals, peer review, providing status reports, and preparing final reports. Issues related to research reproducibility. Guest lectures from professional biomedical informatics systems builders on issues related to the process of project management. Software engineering basics. Because the team projects start in the first week of class, attendance that week is strongly recommended. Prerequisites: BIOMEDIN 210 or 214 or 215 or 217 or 260. Preference to BMI graduate students. Consent of instructor required.
Terms: Spr | Units: 3-5 | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 215: Frontiers in Biological Research (BIOC 215, DBIO 215)

Students analyze cutting edge science, develop a logical framework for evaluating evidence and models, and enhance their ability to design original research through exposure to experimental tools and strategies. The class runs in parallel with the Frontiers in Biological Research seminar series. Students and faculty meet on the Tuesday preceding each seminar to discuss a landmark paper in the speaker's field of research. Following the Wednesday seminar, students meet briefly with the speaker for a free-range discussion which can include insights into the speakers' paths into science and how they pick scientific problems.
Terms: Aut, Win, Spr | Units: 1 | Repeatable for credit | Grading: Medical Satisfactory/No Credit

GENE 216: Practical Considerations and Industry Perspective on Academic-Industry Collaborations

Provides an overview, fundamentals and practical considerations for different aspects of academic-industry collaborations by inviting current industrial experts to share their views and to answer questions. The different aspects include collaboration models, proposal building, IP right sharing, funding opportunities, sabbatical and internship in industry, industry job searching, etc. This class also serves as a platform to connect with Bay Area biotech and pharmaceutical executives and experts.
Terms: Spr | Units: 1 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: ; Duan, D. (PI)

GENE 221: Current Issues in Aging

Current research literature on genetic mechanisms of aging in animals and human beings. Topics include: mitochondria mutations, insulin-like signaling, sirtuins, aging in flies and worms, stem cells, human progeria, and centenarian studies. Prerequisite: GENE 203, 205 or BIOS 200.
Terms: not given this year | Units: 2 | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 224: Principles of Pharmacogenomics (BIOMEDIN 224)

This course is an introduction to pharmacogenomics, including the relevant pharmacology, genomics, experimental methods (sequencing, expression, genotyping), data analysis methods and bioinformatics. The course reviews key gene classes (e.g., cytochromes, transporters) and key drugs (e.g., warfarin, clopidogrel, statins, cancer drugs) in the field. Resources for pharmacogenomics (e.g., PharmGKB, Drugbank, NCBI resources) are reviewed, as well as issues implementing pharmacogenomics testing in the clinical setting. Reading of key papers, including student presentations of this work; problem sets; final project selected with approval of instructor. Prerequisites: two of BIO 41, 42, 43, 44X, 44Y or consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 3 | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 232: Advanced Imaging Lab in Biophysics (APPPHYS 232, BIO 132, BIO 232, BIOPHYS 232)

Laboratory and lectures. Advanced microscopy and imaging, emphasizing hands-on experience with state-of-the-art techniques. Students construct and operate working apparatus. Topics include microscope optics, Koehler illumination, contrast-generating mechanisms (bright/dark field, fluorescence, phase contrast, differential interference contrast), and resolution limits. Laboratory topics vary by year, but include single-molecule fluorescence, fluorescence resonance energy transfer, confocal microscopy, two-photon microscopy, microendoscopy, and optical trapping. Limited enrollment. Recommended: basic physics, basic cell biology, and consent of instructor.
Terms: Spr | Units: 4 | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 268: Biology and Applications of CRISPR/Cas9: Genome Editing and Epigenome Modifications (BIOS 268)

This course is designed to provide a broad overview of the biology and applications of the revolutionary CRISPR/Cas9 system, with detailed exploration of several areas: / / --Basic biology of the CRISPR/Cas9 system / --High-throughput screening using CRISPR/Cas9 / --Epigenetic modifications and transcriptional regulation using dCas9 / --Therapeutic applications of gene editing with CRISPR / --Disease modeling with CRISPR / --Ethical considerations of the use of CRISPR/Cas9 / / The course will be geared toward advanced undergraduates and graduate students, and will assume a basic background in molecular biology and genetics. The course will be lecture-based, with frequent opportunities for discussion and questions.
Terms: Spr | Units: 1 | Grading: Medical Satisfactory/No Credit

GENE 274B: A Case Based Approach to Clinical Genetics (CHPR 274B)

For genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Case-based scenarios and guest expert lectures. Students learn skills in case preparation, management, and presentation, as well as content around common genetic disorders. This course is a continuation of GENE 274A, but may be taken individually with instructor permission.
Terms: Spr | Units: 2 | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 276: Genetic Counseling Clinical Rotations

For genetic counseling students only. Supervised clinical experiences. May be repeated for credit. Prerequisite: GENE 275.
Terms: Aut, Win, Spr, Sum | Units: 1-7 | Repeatable for credit | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 278: Prenatal Genetic Counseling (CHPR 278)

Online course for genetic counseling students, graduate students in genetics, medical students, residents, fellows, and nurses interested in prenatal genetics. Genetic counseling students should take this course in conjunction with their initial prenatal genetics rotation. Topics include: prenatal screening and diagnostic testing, ultrasound, genetic carrier screening, teratology, fetal treatment and intervention, perinatal loss, termination, and infertility.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit

GENE 279: Pediatric and Adult Genetic Counseling (CHPR 279)

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their initial general genetics rotation. Topics include: common genetic conditions, assessment of child development and medical history in the context of a genetic workup, the pediatric genetics medical examination, dysmorphology, introduction to laboratory genetic testing, development of a differential diagnosis, and resources for case management and family support.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Hanson-Kahn, A. (PI)

GENE 280: Metabolic Genetic Counseling (CHPR 280)

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows genetic counseling students should take this course in conjunction with their metabolic genetics rotation. Topics include: overview of metabolic diseases; common pathways; diagnosis, management, and treatment of metabolic disorders; and newborn screening.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Hanson-Kahn, A. (PI)

GENE 281: Cancer Genetic Counseling (CHPR 281)

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their initial cancer genetics rotation. Topics include: cancer biology and cytogenetics; diagnosis and management of common cancer genetic syndromes¿ predictive testing; psychology of cancer genetic counseling; and topics recommended by ASCO guidelines.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Ormond, K. (PI)

GENE 282B: Genetic Counseling Research Seminar

For genetic counseling students only. Lectures and facilitated discussions on research methodology for genetic counseling departmental research projects. Prerequisite: GENE 282A.
Terms: Spr | Units: 1 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: ; Ormond, K. (PI)

GENE 283: Genetic Counseling Research

Genetic counseling students conduct clinical research projects as required by the department for graduation. May be repeated for credit. Pre- or corequisite: GENE 282.
Terms: Aut, Win, Spr, Sum | Units: 1-8 | Repeatable for credit | Grading: Medical Satisfactory/No Credit

GENE 284: Medical Genetics Seminar (CHPR 284)

Presentation of genetics research and cases from the medical genetics and biochemical genetics services. Course may be completed online or in person. Non-GC students: please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1 | Repeatable for credit | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 285C: Genetic Counseling Seminar

Year-long seminar primarily for genetic counseling students. Spring: The application of counseling theories, models, and therapy to the practice of genetic counseling
Terms: Spr | Units: 3 | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 286: Advanced Genetic Counseling Seminar

For genetic counseling students only. Psychosocial issues associated with genetic counseling cases are discussed through presentation of cases that students have seen throughout their training. Professional development topics will be included. Must be taken for 3 quarters. Prerequisites: GENE 285 A,B,C and 276.
Terms: Aut, Win, Spr | Units: 2 | Repeatable for credit | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 287: CARDIOVASCULAR GENETICS (CHPR 287)

Online course for genetic counseling students, graduate students in genetics, medical students, residents, fellows, and nurses interested in inherited cardiovascular conditions. Genetic counseling students should take this course in conjunction with their cardiovascular genetics rotation. Topics include: Basic cardiology principles, including relevant anatomy and physiology; diagnosis, management and genetic testing as it relates to common inherited cardiovascular conditions in both the pediatric and adult setting; predictive genetic testing issues specific to inherited cardiovascular conditions; psychological issues related to sudden death conditions.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit

GENE 288: Neurogenetics

Internet-based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellow; genetic counseling students should take this course in conjunction with their neurogenetics rotation. Topics include: introduction to neurology for beginners, including an overview of neurologic exam and localization, to provide non-neurologist trainees a foundation for understanding the differential diagnosis process in neurology; common and exemplary neurogenetics disorders spanning the adult and pediatric neurologic sub-specialties; key genetic concepts such as triple repeat disorders and FSHD; ethical and psychological topics as well as gene-targets therapeutics. nnMedical students and graduate students outside of genetic counseling should obtain permission from instructor prior to enrollment. No prerequisite for genetic counseling students, genetics or neurology residents/fellows or post-docs.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Ormond, K. (PI)

GENE 346: Advanced Seminar on Prokaryotic Molecular Biology (BIO 346, CSB 346)

Enrollment limited to PhD students associated with departmental research groups in genetics or molecular biology.
Terms: Aut, Win, Spr | Units: 1 | Grading: Satisfactory/No Credit
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