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BIOPHYS 244: Mechanotransduction in Cells and Tissues (BIOE 283, ME 244)

Mechanical cues play a critical role in development, normal functioning of cells and tissues, and various diseases. This course will cover what is known about cellular mechanotransduction, or the processes by which living cells sense and respond to physical cues such as physiological forces or mechanical properties of the tissue microenvironment. Experimental techniques and current areas of active investigation will be highlighted. This class is for graduate students only.
Terms: Aut | Units: 3 | Grading: Letter (ABCD/NP)
Instructors: ; Chaudhuri, O. (PI)

BIOPHYS 250: Seminar in Biophysics

Required of Biophysics graduate students. Presentation of current research projects and results by faculty in the Biophysics program. May be repeated for credit. BIOPHYS 250 is a seminar course intended only for first year Biophysics and Structural Biology graduate students, to help them decide on which faculty labs they want to settle in.
Terms: Aut | Units: 1 | Repeatable for credit | Grading: Satisfactory/No Credit
Instructors: ; Weis, W. (PI)

BIOPHYS 279: Computational Biology: Structure and Organization of Biomolecules and Cells (BIOE 279, BIOMEDIN 279, CME 279, CS 279)

Computational techniques for investigating and designing the three-dimensional structure and dynamics of biomolecules and cells. These computational methods play an increasingly important role in drug discovery, medicine, bioengineering, and molecular biology. Course topics include protein structure prediction, protein design, drug screening, molecular simulation, cellular-level simulation, image analysis for microscopy, and methods for solving structures from crystallography and electron microscopy data. Prerequisites: elementary programming background (CS 106A or equivalent) and an introductory course in biology or biochemistry.
Terms: Aut | Units: 3 | Grading: Letter or Credit/No Credit
Instructors: ; Dror, R. (PI); Huang, P. (PI)

BIOPHYS 294: Cellular Biophysics (APPPHYS 294, BIO 294)

Physical biology of dynamical and mechanical processes in cells. Emphasis is on qualitative understanding of biological functions through quantitative analysis and simple mathematical models. Sensory transduction, signaling, adaptation, switches, molecular motors, actin and microtubules, motility, and circadian clocks. Prerequisites: differential equations and introductory statistical mechanics.
Terms: Aut | Units: 3 | Grading: Letter or Credit/No Credit
Instructors: ; Fisher, D. (PI)

BIOPHYS 300: Graduate Research

Investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit | Grading: Satisfactory/No Credit

BIOPHYS 392: Topics in Molecular Biophysics: Biophysics of Functional RNA (BIOPHYS 392) (APPPHYS 392)

Survey of methods used to relate RNA sequences to the structure and function of transcribed RNA molecules. Computation of contributions of the counter-ion cloud to the dependence of free energy on conformation of the folded RNA. The relation of structure to function of ribozymes, riboswitches, and the formation of ribosomal proteins.
Terms: Aut | Units: 3 | Grading: Letter or Credit/No Credit
Instructors: ; Doniach, S. (PI)
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