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BIOE 212: Introduction to Biomedical Informatics Research Methodology (BIOMEDIN 212, CS 272, GENE 212)

Capstone Biomedical Informatics (BMI) experience. Hands-on software building. Student teams conceive, design, specify, implement, evaluate, and report on a software project in the domain of biomedicine. Creating written proposals, peer review, providing status reports, and preparing final reports. Issues related to research reproducibility. Guest lectures from professional biomedical informatics systems builders on issues related to the process of project management. Software engineering basics. Because the team projects start in the first week of class, attendance that week is strongly recommended. Prerequisites: BIOMEDIN 210 or 214 or 215 or 217 or 260. Preference to BMI graduate students. Consent of instructor required.
Terms: Spr | Units: 3-5

BIOMEDIN 156: Economics of Health and Medical Care (BIOMEDIN 256, ECON 126, HRP 256)

Institutional, theoretical, and empirical analysis of the problems of health and medical care. Topics: demand for medical care and medical insurance; institutions in the health sector; economics of information applied to the market for health insurance and for health care; measurement and valuation of health; competition in health care delivery. Graduate students with research interests should take ECON 249. Prerequisites: ECON 50 and either ECON 102A or STATS 116 or the equivalent. Recommended: ECON 51.
Last offered: Spring 2020 | Units: 5 | UG Reqs: WAY-SI

BIOMEDIN 201: Biomedical Informatics Student Seminar

Participants report on recent articles from the Biomedical Informatics literature or their research projects. Goals are to teach critical reading of scientific papers and presentation skills. May be repeated three times for credit.
Terms: Aut, Win, Spr, Sum | Units: 1 | Repeatable 3 times (up to 3 units total)
Instructors: ; Plevritis, S. (PI)

BIOMEDIN 205: Precision Practice with Big Data

Primarily for M.D. students; open to other graduate students. Provides an overview of how to leverage large amounts of clinical, molecular, and imaging data within hospitals and in cyberspace--big data--to practice medicine more effectively. Lectures by physicians, researchers, and industry leaders survey how the major methods of informatics can help physicians leverage big data to profile disease, to personalize treatment to patients, to predict treatment response, to discover new knowledge, and to challenge established medical dogma and the current paradigm of clinical decision-making based solely on published knowledge and individual physician experience. May be repeated for credit. Prerequisite: background in biomedicine. Background in computer science can be helpful but not required.
Terms: Aut | Units: 1

BIOMEDIN 206: Informatics in Industry

Effective management, modeling, acquisition, and mining of biomedical information in healthcare and biotechnology companies and approaches to information management adopted by companies in this ecosystem. Guest speakers from pharmaceutical/biotechnology companies, clinics/hospitals, health communities/portals, instrumentation/software vendors. May be repeated for credit.
Last offered: Spring 2019 | Units: 1 | Repeatable for credit

BIOMEDIN 207: Seminar: Health IT in Care Delivery systems

The practice of medicine is reacting quickly to the avalanche of information available from electronic health records and data directly submitted by patients and from the environment. This seminar, comprised of guest lectures from industry and academia, will highlight the practical challenges and successes of how health IT has transformed care delivery programs. The seminar will cover current efforts in clinical decision support, patient-centered design, integration with community care, big data, medical education, and the innovation pipeline for healthcare delivery organizations.
Terms: Sum | Units: 1

BIOMEDIN 208: Clinical Informatics Literature Review Seminar

Weekly seminar series in which seminal literature and current publications in the field of clinical informatics are reviewed and discussed. Organized by the Stanford Clinical Informatics fellowship program. Topics include electronic health record design, implementation, and evaluation; patient engagement; provider satisfaction; and hot topics in clinical informatics. Limited enrollment.
Terms: Spr | Units: 1

BIOMEDIN 210: Modeling Biomedical Systems (CS 270)

At the core of informatics is the problem of creating computable models of biomedical phenomena. This course explores methods for modeling biomedical systems with an emphasis on contemporary semantic technology, including knowledge graphs. Topics: data modeling, knowledge representation, controlled terminologies, ontologies, reusable problem solvers, modeling problems in healthcare information technology and other aspects of informatics. Students acquire hands-on experience with several systems and tools. Prerequisites: CS106A. Basic familiarity with Python programming, biology, probability, and logic are assumed.
Terms: Win | Units: 3

BIOMEDIN 212: Introduction to Biomedical Informatics Research Methodology (BIOE 212, CS 272, GENE 212)

Capstone Biomedical Informatics (BMI) experience. Hands-on software building. Student teams conceive, design, specify, implement, evaluate, and report on a software project in the domain of biomedicine. Creating written proposals, peer review, providing status reports, and preparing final reports. Issues related to research reproducibility. Guest lectures from professional biomedical informatics systems builders on issues related to the process of project management. Software engineering basics. Because the team projects start in the first week of class, attendance that week is strongly recommended. Prerequisites: BIOMEDIN 210 or 214 or 215 or 217 or 260. Preference to BMI graduate students. Consent of instructor required.
Terms: Spr | Units: 3-5

BIOMEDIN 214: Representations and Algorithms for Computational Molecular Biology (BIOE 214, CS 274, GENE 214)

Topics: introduction to bioinformatics and computational biology, algorithms for alignment of biological sequences and structures, computing with strings, phylogenetic tree construction, hidden Markov models, basic structural computations on proteins, protein structure prediction, protein threading techniques, homology modeling, molecular dynamics and energy minimization, statistical analysis of 3D biological data, integration of data sources, knowledge representation and controlled terminologies for molecular biology, microarray analysis, machine learning (clustering and classification), and natural language text processing. Prerequisite: CS 106B; recommended: CS161; consent of instructor for 3 units.
Terms: Aut | Units: 3-4

BIOMEDIN 215: Data Science for Medicine

The widespread adoption of electronic health records (EHRs) has created a new source of big data namely, the record of routine clinical practice as a by-product of care. This graduate class will teach you how to use EHRs and other patient data to discover new clinical knowledge and improve healthcare. Upon completing this course, you should be able to: differentiate between and give examples of categories of research questions and the study designs used to address them, describe common healthcare data sources and their relative advantages and limitations, extract and transform various kinds of clinical data to create analysis-ready datasets, design and execute an analysis of a clinical dataset based on your familiarity with the workings, applicability, and limitations of common statistical methods, evaluate and criticize published research using your knowledge of 1-4 to generate new research ideas and separate hype from reality. Prerequisites: CS 106A or equivalent, STATS 60 or equivalent. Recommended: STATS 216, CS 145, STATS 305
Terms: Aut | Units: 3

BIOMEDIN 216: Representations and Algorithms for Molecular Biology: Lectures

Lecture component of BIOMEDIN 214. One unit for medical and graduate students who attend lectures only; may be taken for 2 units with participation in limited assignments and final project. Lectures also available via internet. Prerequisite: familiarity with biology recommended.
Terms: Aut | Units: 1-2
Instructors: ; Altman, R. (PI)

BIOMEDIN 217: Translational Bioinformatics (BIOE 217, CS 275, GENE 217)

Computational methods for the translation of biomedical data into diagnostic, prognostic, and therapeutic applications in medicine. Topics: multi-scale omics data generation and analysis, utility and limitations of public biomedical resources, machine learning and data mining, issues and opportunities in drug discovery, and mobile/digital health solutions. Case studies and course project. Prerequisites: programming ability at the level of CS 106A and familiarity with biology and statistics.
Terms: Win | Units: 4

BIOMEDIN 219: Mathematical Models and Medical Decisions

Analytic methods for determining optimal diagnostic and therapeutic decisions with applications to the care of individual patients and the design of policies applied to patient populations. Topics include: utility theory and probability modeling, empirical methods for disease prevalence estimation, probability models for periodic processes, binary decision-making techniques, Markov models of dynamic disease state problems, utility assessment techniques, parametric utility models, utility models for multidimensional outcomes, analysis of time-varying clinical outcomes, and the design of cost-constrained clinical policies. Extensive problem sets compliment the lectures. Prerequisites: introduction to calculus and basic statistics.
Terms: Win | Units: 3

BIOMEDIN 220: Artificial Intelligence in Healthcare (BIODS 220, CS 271)

Healthcare is one of the most exciting application domains of artificial intelligence, with transformative potential in areas ranging from medical image analysis to electronic health records-based prediction and precision medicine. This course will involve a deep dive into recent advances in AI in healthcare, focusing in particular on deep learning approaches for healthcare problems. We will start from foundations of neural networks, and then study cutting-edge deep learning models in the context of a variety of healthcare data including image, text, multimodal and time-series data. In the latter part of the course, we will cover advanced topics on open challenges of integrating AI in a societal application such as healthcare, including interpretability, robustness, privacy and fairness. The course aims to provide students from diverse backgrounds with both conceptual understanding and practical grounding of cutting-edge research on AI in healthcare. Prerequisites: Proficiency in Python or ability to self-learn; familiarity with machine learning and basic calculus, linear algebra, statistics; familiarity with deep learning highly recommended (e.g. prior experience training a deep learning model)..
Terms: Aut | Units: 3-4
Instructors: ; Yeung, S. (PI)

BIOMEDIN 221: Machine Learning Approaches for Data Fusion in Biomedicine

Vast amounts of biomedical data are now routinely available for patients, raging from genomic data, to radiographic images and electronic health records. AI and machine learning are increasingly used to enable pattern discover to link such data for improvements in patient diagnosis, prognosis and tailoring treatment response. Yet, few studies focus on how to link different types of biomedical data in synergistic ways, and to develop data fusion approaches for improved biomedical decision support. This course will describe approaches for multi-omics, multi-modal and multi-scale data fusion of biomedical data in the context of biomedical decision support. Prerequisites: CS106A or equivalent, Stats 60 or equivalent.
Terms: Aut | Units: 2

BIOMEDIN 222: Cloud Computing for Biology and Healthcare (CS 273C, GENE 222)

Big Data is radically transforming healthcare. To provide real-time personalized healthcare, we need hardware and software solutions that can efficiently store and process large-scale biomedical datasets. In this class, students will learn the concepts of cloud computing and parallel systems' architecture. This class prepares students to understand how to design parallel programs for computationally intensive medical applications and how to run these applications on computing frameworks such as Cloud Computing and High Performance Computing (HPC) systems. Prerequisites: familiarity with programming in Python and R.
Terms: Spr | Units: 3

BIOMEDIN 224: Principles of Pharmacogenomics (GENE 224)

This course is an introduction to pharmacogenomics, including the relevant pharmacology, genomics, experimental methods (sequencing, expression, genotyping), data analysis methods and bioinformatics. The course reviews key gene classes (e.g., cytochromes, transporters) and key drugs (e.g., warfarin, clopidogrel, statins, cancer drugs) in the field. Resources for pharmacogenomics (e.g., PharmGKB, Drugbank, NCBI resources) are reviewed, as well as issues implementing pharmacogenomics testing in the clinical setting. Reading of key papers, including student presentations of this work; problem sets; final project selected with approval of instructor. Prerequisites: two of BIO 41, 42, 43, 44X, 44Y or consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 3

BIOMEDIN 225: Data Driven Medicine: Lectures

Lectures for BIOMEDIN 215.With the spread of electronic health records and increasingly low cost assays for patient molecular data, powerful data repositories with tremendous potential for biomedical research, clinical care and personalized medicine are being built. But these databases are large and difficult for any one specialist to analyze. To find the hidden associations within the full set of data, we introduce methods for data-mining at the internet scale, the handling of large-scale electronic medical records data for machine learning, methods in natural language processing and text-mining applied to medical records, methods for using ontologies for the annotation and indexing of unstructured content as well as semantic web technologies. Prerequisites: familiarity with statistics (STATS 216) and biology.
Last offered: Autumn 2019 | Units: 2

BIOMEDIN 226: Digital Health Practicum in a Health Care Delivery System

Practical experience implementing clinical informatics solutions with a focus on digital health in one of the largest healthcare delivery systems in the United States. Individual meetings with senior clinical informatics leaders to discuss elements of successful projects. Implementation opportunities include supporting the use of electronic health records, engagement of patients and providers via a personal health record, use of informatics to support patient service centers, and improvement of patient access to clinical data. Consent of course instructors required at least one quarter prior to student enrollment in course.
Terms: Aut, Win | Units: 2-3

BIOMEDIN 233: Intermediate Biostatistics: Analysis of Discrete Data (EPI 261, STATS 261)

(Formerly HRP 261) Methods for analyzing data from case-control and cross-sectional studies: the 2x2 table, chi-square test, Fisher's exact test, odds ratios, Mantel-Haenzel methods, stratification, tests for matched data, logistic regression, conditional logistic regression. Emphasis is on data analysis in SAS or R. Special topics: cross-fold validation and bootstrap inference.
Terms: Win | Units: 3

BIOMEDIN 240: Race, Data Algorithms, and Health (BIODS 240)

This course studies the interplay between race, data and algorithms in healthcare. The particular viewpoint we want to take is to understand the role of data, data analysis and algorithms in supporting equitable delivery of health care to members of all races. Topics as "representative data", "machine bias", "algorithmic fairness" are going to be central to the discussion. However, we want to stress the uniqueness of the "medicine/health care" viewpoint. For example, while in contexts as loan applications, it is normative that race information (or its proxies) not to be included among the variables used for decision, in healthcare, information on race is routinely collected in the attempt to provide "best" care. One of the goals of the class will be to understand what are the differences between biological populations and social environments that a doctor needs to be aware of as opposed to overly emphasized or imaginary ones. This will provide a context to understand the challenges that data collection and analysis faces to support equitable care.
Terms: Aut | Units: 1
Instructors: ; Sabatti, C. (PI); Zou, J. (PI)

BIOMEDIN 245: Statistical and Machine Learning Methods for Genomics (BIO 268, CS 373, STATS 345)

Introduction to statistical and computational methods for genomics. Sample topics include: expectation maximization, hidden Markov model, Markov chain Monte Carlo, ensemble learning, probabilistic graphical models, kernel methods and other modern machine learning paradigms. Rationales and techniques illustrated with existing implementations used in population genetics, disease association, and functional regulatory genomics studies. Instruction includes lectures and discussion of readings from primary literature. Homework and projects require implementing some of the algorithms and using existing toolkits for analysis of genomic datasets.
Last offered: Winter 2020 | Units: 3

BIOMEDIN 246: Seminar in Healthcare Quality and Safety (HRP 246)

Primarily for medical students in the Quality and Safety Scholarly Concentration. Almost everyone will be a patient at some point in their lives. It is estimated that over 98,000 patients die in US hospitals each year due to medical errors and recent articles suggest that medical errors are the third leading cause of death in the US. Patient safety is the foundation of high-quality health care, which has become a critical issue in health policy discussions. This course will provide an overview of the quality & patient safety movement, the array of measurement techniques and issues, and perspectives of quality improvement efforts under the current policy landscape. Lunch will be provided for enrolled students.
Last offered: Winter 2019 | Units: 1

BIOMEDIN 248: Clinical Trial Design in the Age of Precision Medicine and Health (BIODS 248, BIODS 248P, STATS 248)

Overview of requirements, designs, and statistical foundations for traditional Phase I, II, and III clinical trials for medical product approval and Phase IV postmarketing studies for safety evaluation. As these methods cost too much and take too much time in the era of precision medicine and precision health, this course then introduces innovative designs that have been developed for affordable clinical trials, which can be completed within reasonable time constraints and which have been encouraged by regulatory agencies. Prerequisites: Working knowledge of statistics and R.
Last offered: Spring 2020 | Units: 3

BIOMEDIN 251: Outcomes Analysis (HRP 252, MED 252)

Methods of conducting empirical studies which use large existing medical, survey, and other databases to ask both clinical and policy questions. Econometric and statistical models used to conduct medical outcomes research. How research is conducted on medical and health economics questions when a randomized trial is impossible. Problem sets emphasize hands-on data analysis and application of methods, including re-analyses of well-known studies. Prerequisites: one or more courses in probability, and statistics or biostatistics.
Last offered: Spring 2020 | Units: 4

BIOMEDIN 254: Quality & Safety in U.S. Healthcare (HRP 254)

The course will provide an in-depth examination of the quality & patient safety movement in the US healthcare system, the array of quality measurement techniques and issues, and perspectives of quality and safety improvement efforts under the current policy landscape.
Last offered: Autumn 2018 | Units: 3

BIOMEDIN 256: Economics of Health and Medical Care (BIOMEDIN 156, ECON 126, HRP 256)

Institutional, theoretical, and empirical analysis of the problems of health and medical care. Topics: demand for medical care and medical insurance; institutions in the health sector; economics of information applied to the market for health insurance and for health care; measurement and valuation of health; competition in health care delivery. Graduate students with research interests should take ECON 249. Prerequisites: ECON 50 and either ECON 102A or STATS 116 or the equivalent. Recommended: ECON 51.
Last offered: Spring 2020 | Units: 5

BIOMEDIN 260: Computational Methods for Biomedical Image Analysis and Interpretation (CS 235, RAD 260)

The latest biological and medical imaging modalities and their applications in research and medicine. Focus is on computational analytic and interpretive approaches to optimize extraction and use of biological and clinical imaging data for diagnostic and therapeutic translational medical applications. Topics include major image databases, fundamental methods in image processing and quantitative extraction of image features, structured recording of image information including semantic features and ontologies, indexing, search and content-based image retrieval. Case studies include linking image data to genomic, phenotypic and clinical data, developing representations of image phenotypes for use in medical decision support and research applications and the role that biomedical imaging informatics plays in new questions in biomedical science. Includes a project. Enrollment for 3 units requires instructor consent. Prerequisites: programming ability at the level of CS 106A, familiarity with statistics, basic biology. Knowledge of Matlab or Python highly recommended.
Terms: Spr | Units: 3-4

BIOMEDIN 273A: The Human Genome Source Code (CS 273A, DBIO 273A)

A computational primer to "hacking" the most amazing operating system "disk" on the planet: your genome. Handling genomic data is deceptively easy. But that's muscle. You want to be the brain, too. Topics include genome sequencing (assembling source code from code fragments); the human genome functional landscape: variable assignments (genes), control-flow logic (gene regulation) and run-time stack (epigenomics); human disease and personalized genomics (as a hunt for bugs in the human code); genome editing (code injection) to cure the incurable; and the source code modifications behind amazing animal adaptations. The course will introduce ideas from computational genomics, machine learning and natural language processing. Course includes primers on molecular biology, and text processing languages. Prerequisites: CS106A or equivalent. No biological background assumed.
Terms: Win | Units: 3
Instructors: ; Bejerano, G. (PI)

BIOMEDIN 273B: Deep Learning in Genomics and Biomedicine (BIODS 237, CS 273B, GENE 236)

Recent breakthroughs in high-throughput genomic and biomedical data are transforming biological sciences into "big data" disciplines. In parallel, progress in deep neural networks are revolutionizing fields such as image recognition, natural language processing and, more broadly, AI. This course explores the exciting intersection between these two advances. The course will start with an introduction to deep learning and overview the relevant background in genomics and high-throughput biotechnology, focusing on the available data and their relevance. It will then cover the ongoing developments in deep learning (supervised, unsupervised and generative models) with the focus on the applications of these methods to biomedical data, which are beginning to produced dramatic results. In addition to predictive modeling, the course emphasizes how to visualize and extract interpretable, biological insights from such models. Recent papers from the literature will be presented and discussed. Students will be introduced to and work with popular deep learning software frameworks. Students will work in groups on a final class project using real world datasets. Prerequisites: College calculus, linear algebra, basic probability and statistics such as CS 109, and basic machine learning such as CS 229. No prior knowledge of genomics is necessary.
Terms: Aut | Units: 3
Instructors: ; Kundaje, A. (PI); Zou, J. (PI)

BIOMEDIN 279: Computational Biology: Structure and Organization of Biomolecules and Cells (BIOE 279, BIOPHYS 279, CME 279, CS 279)

Computational techniques for investigating and designing the three-dimensional structure and dynamics of biomolecules and cells. These computational methods play an increasingly important role in drug discovery, medicine, bioengineering, and molecular biology. Course topics include protein structure prediction, protein design, drug screening, molecular simulation, cellular-level simulation, image analysis for microscopy, and methods for solving structures from crystallography and electron microscopy data. Prerequisites: elementary programming background (CS 106A or equivalent) and an introductory course in biology or biochemistry.
Terms: Aut | Units: 3
Instructors: ; Dror, R. (PI)

BIOMEDIN 290: Biomedical Informatics Teaching Methods

Hands-on training in biomedical informatics pedagogy. Practical experience in pedagogical approaches, variously including didactic, inquiry, project, team, case, field, and/or problem-based approaches. Students create course content, including lectures, exercises, and assessments, and evaluate learning activities and outcomes. Prerequisite: instructor consent.
Terms: Aut, Win, Spr, Sum | Units: 1-6 | Repeatable 2 times (up to 6 units total)
Instructors: ; Altman, R. (PI); Ashley, E. (PI); Bassik, M. (PI); Batzoglou, S. (PI); Bayati, M. (PI); Bejerano, G. (PI); Bhattacharya, J. (PI); Blish, C. (PI); Boahen, K. (PI); Brandeau, M. (PI); Bustamante, C. (PI); Butte, A. (PI); Chang, H. (PI); Cherry, J. (PI); Cohen, S. (PI); Covert, M. (PI); Curtis, C. (PI); Das, A. (PI); Das, R. (PI); Davis, R. (PI); Delp, S. (PI); Desai, M. (PI); Dill, D. (PI); Dumontier, M. (PI); Elias, J. (PI); Fagan, L. (PI); Feldman, M. (PI); Ferrell, J. (PI); Fraser, H. (PI); Gerritsen, M. (PI); Gevaert, O. (PI); Goldstein, M. (PI); Greenleaf, W. (PI); Guibas, L. (PI); Hastie, T. (PI); Hlatky, M. (PI); Holmes, S. (PI); Ji, H. (PI); Karp, P. (PI); Khatri, P. (PI); Kim, S. (PI); Kirkegaard, K. (PI); Klein, T. (PI); Koller, D. (PI); Krummel, T. (PI); Kundaje, A. (PI); Levitt, M. (PI); Levitt, R. (PI); Li, J. (PI); Longhurst, C. (PI); Lowe, H. (PI); Mallick, P. (PI); Manning, C. (PI); McAdams, H. (PI); Menon, V. (PI); Montgomery, S. (PI); Musen, M. (PI); Napel, S. (PI); Nolan, G. (PI); Olshen, R. (PI); Owen, A. (PI); Owens, D. (PI); Paik, D. (PI); Palacios, J. (PI); Pande, V. (PI); Petrov, D. (PI); Plevritis, S. (PI); Poldrack, R. (PI); Pritchard, J. (PI); Relman, D. (PI); Riedel-Kruse, I. (PI); Rivas, M. (PI); Rubin, D. (PI); Sabatti, C. (PI); Salzman, J. (PI); Shachter, R. (PI); Shafer, R. (PI); Shah, N. (PI); Sherlock, G. (PI); Sidow, A. (PI); Snyder, M. (PI); Tang, H. (PI); Taylor, C. (PI); Theriot, J. (PI); Tibshirani, R. (PI); Utz, P. (PI); Walker, M. (PI); Wall, D. (PI); Winograd, T. (PI); Wong, W. (PI); Xing, L. (PI); Zou, J. (PI)

BIOMEDIN 299: Directed Reading and Research

For students wishing to receive credit for directed reading or research time. Prerequisite: consent of instructor. (Staff)
Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit
Instructors: ; Altman, R. (PI); Ashley, E. (PI); Baiocchi, M. (PI); Bassik, M. (PI); Batzoglou, S. (PI); Bayati, M. (PI); Bejerano, G. (PI); Bhattacharya, J. (PI); Blish, C. (PI); Boahen, K. (PI); Brandeau, M. (PI); Brunet, A. (PI); Brutlag, D. (PI); Bustamante, C. (PI); Butte, A. (PI); Chang, H. (PI); Chen, J. (PI); Cherry, J. (PI); Cohen, S. (PI); Covert, M. (PI); Curtis, C. (PI); Das, A. (PI); Das, R. (PI); Davis, R. (PI); Delp, S. (PI); Desai, M. (PI); Dill, D. (PI); Dinakarpandian, D. (PI); Dror, R. (PI); Dumontier, M. (PI); Elias, J. (PI); Fagan, L. (PI); Feldman, M. (PI); Ferrell, J. (PI); Fraser, H. (PI); Gentles, A. (PI); Gerritsen, M. (PI); Gevaert, O. (PI); Goldstein, M. (PI); Greenleaf, W. (PI); Guibas, L. (PI); Hastie, T. (PI); Hernandez-Boussard, T. (PI); Hlatky, M. (PI); Holmes, S. (PI); Ji, H. (PI); Karp, P. (PI); Khatri, P. (PI); Kim, S. (PI); Kirkegaard, K. (PI); Klein, T. (PI); Koller, D. (PI); Krummel, T. (PI); Kundaje, A. (PI); Langlotz, C. (PI); Levitt, M. (PI); Li, J. (PI); Longhurst, C. (PI); Lowe, H. (PI); Mallick, P. (PI); Manning, C. (PI); McAdams, H. (PI); Menon, V. (PI); Montgomery, S. (PI); Musen, M. (PI); Napel, S. (PI); Nolan, G. (PI); Olshen, R. (PI); Owen, A. (PI); Owens, D. (PI); Paik, D. (PI); Palacios, J. (PI); Pande, V. (PI); Petrov, D. (PI); Plevritis, S. (PI); Poldrack, R. (PI); Pritchard, J. (PI); Qi, S. (PI); Relman, D. (PI); Riedel-Kruse, I. (PI); Rivas, M. (PI); Rubin, D. (PI); Sabatti, C. (PI); Salzman, J. (PI); Shachter, R. (PI); Shafer, R. (PI); Shah, N. (PI); Sherlock, G. (PI); Sidow, A. (PI); Snyder, M. (PI); Tang, H. (PI); Taylor, C. (PI); Theriot, J. (PI); Tibshirani, R. (PI); Tu, S. (PI); Utz, P. (PI); Walker, M. (PI); Wall, D. (PI); Winograd, T. (PI); Wong, W. (PI); Xing, L. (PI); Zou, J. (PI)

BIOMEDIN 304: Clinical Experience Seminar for Students in Biomedical Informatics

This seminar is intended to expose Biomedical Informatics graduate students to clinical environments where informatics is being applied. Students will shadow clinical care and interact with physicians and other allied health professionals throughout Stanford Healthcare and Stanford Children's Health during weekly sessions. Students will be asked to reflect on their experiences and discuss future applications to informatics projects. Preference will be given to senior students. Requires Course Director approval for enrollment - students should register 30 days prior to the first day of class for consideration. Prerequisites: School of Medicine HIPAA Training; Occupational Health clearance; SHC Compliance Attestation. All prerequisites must be submitted 2 weeks before the 1st day in order to ensure hospital compliance.
Terms: Win, Sum | Units: 1

BIOMEDIN 370: Medical Scholars Research

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.
Terms: Aut, Win, Spr, Sum | Units: 4-18 | Repeatable for credit
Instructors: ; Altman, R. (PI); Ashley, E. (PI); Bassik, M. (PI); Batzoglou, S. (PI); Bayati, M. (PI); Bejerano, G. (PI); Bhattacharya, J. (PI); Blish, C. (PI); Boahen, K. (PI); Brandeau, M. (PI); Brutlag, D. (PI); Bustamante, C. (PI); Butte, A. (PI); Chang, H. (PI); Chen, J. (PI); Cherry, J. (PI); Cohen, S. (PI); Covert, M. (PI); Curtis, C. (PI); Das, A. (PI); Das, R. (PI); Davis, R. (PI); Delp, S. (PI); Desai, M. (PI); Dill, D. (PI); Dumontier, M. (PI); Elias, J. (PI); Fagan, L. (PI); Feldman, M. (PI); Ferrell, J. (PI); Fraser, H. (PI); Gerritsen, M. (PI); Gevaert, O. (PI); Goldstein, M. (PI); Greenleaf, W. (PI); Guibas, L. (PI); Hastie, T. (PI); Hlatky, M. (PI); Holmes, S. (PI); Ji, H. (PI); Karp, P. (PI); Khatri, P. (PI); Kim, S. (PI); Kirkegaard, K. (PI); Klein, T. (PI); Koller, D. (PI); Krummel, T. (PI); Kundaje, A. (PI); Levitt, M. (PI); Li, J. (PI); Longhurst, C. (PI); Lowe, H. (PI); Mallick, P. (PI); Manning, C. (PI); McAdams, H. (PI); Menon, V. (PI); Montgomery, S. (PI); Musen, M. (PI); Napel, S. (PI); Nolan, G. (PI); Olshen, R. (PI); Owen, A. (PI); Owens, D. (PI); Paik, D. (PI); Palacios, J. (PI); Pande, V. (PI); Petrov, D. (PI); Plevritis, S. (PI); Poldrack, R. (PI); Pritchard, J. (PI); Relman, D. (PI); Riedel-Kruse, I. (PI); Rivas, M. (PI); Rubin, D. (PI); Sabatti, C. (PI); Salzman, J. (PI); Shachter, R. (PI); Shafer, R. (PI); Shah, N. (PI); Sherlock, G. (PI); Sidow, A. (PI); Snyder, M. (PI); Tang, H. (PI); Taylor, C. (PI); Theriot, J. (PI); Tibshirani, R. (PI); Tu, S. (PI); Utz, P. (PI); Walker, M. (PI); Wall, D. (PI); Winograd, T. (PI); Wong, W. (PI); Xing, L. (PI); Zou, J. (PI)

BIOMEDIN 371: Computational Biology in Four Dimensions (BIOPHYS 371, CME 371, CS 371)

Cutting-edge research on computational techniques for investigating and designing the three-dimensional structure and dynamics of biomolecules, cells, and everything in between. These techniques, which draw on approaches ranging from physics-based simulation to machine learning, play an increasingly important role in drug discovery, medicine, bioengineering, and molecular biology. Course is devoted primarily to reading, presentation, discussion, and critique of papers describing important recent research developments. Prerequisite: CS 106A or equivalent, and an introductory course in biology or biochemistry. Recommended: some experience in mathematical modeling (does not need to be a formal course).
Last offered: Winter 2018 | Units: 3

BIOMEDIN 388: Stakeholder Competencies for Artificial Intelligence in Healthcare (BIODS 388)

Advancements of machine learning and AI into all areas of medicine are now a reality and they hold the potential to transform healthcare and open up a world of incredible promise for everyone. But we will never realize the potential for these technologies unless all stakeholders have basic competencies in both healthcare and machine learning concepts and principles - this will allow successful, responsible development and deployment of these systems into the healthcare domain. The focus of this course is on the key concepts and principles rather than programming or engineering implementation. Those with backgrounds in healthcare, health policy, healthcare system leadership, pharmaceutical, and clinicians as well as those with data science backgrounds who are new to healthcare applications will be empowered with the knowledge to responsibly and ethically evaluate, critically review, and even use these technologies in healthcare. We will cover machine learning approaches, medical use cases in depth, unique metrics to healthcare, important challenges and pitfalls, and best practices for designing, building, and evaluating machine learning in healthcare applications.
Terms: Aut | Units: 2-3

BIOMEDIN 390A: Curricular Practical Training

Provides educational opportunities in biomedical informatics research. Qualified biomedical informatics students engage in internship work and integrate that work into their academic program. Students register during the quarter they are employed and must complete a research report outlining their work activity, problems investigated, key results, and any follow-up on projects they expect to perform. BIOMEDIN 390A, B, and C may each be taken only once.
Terms: Aut, Win, Spr, Sum | Units: 1
Instructors: ; Musen, M. (PI); Tian, L. (PI)

BIOMEDIN 390B: Curricular Practical Training

Provides educational opportunities in biomedical informatics research. Qualified biomedical informatics students engage in internship work and integrate that work into their academic program. Students register during the quarter they are employed and must complete a research report outlining their work activity, problems investigated, key results, and any follow-up on projects they expect to perform. BIOMEDIN 390A, B, and C may each be taken only once.
Terms: Aut, Win, Spr, Sum | Units: 1
Instructors: ; Musen, M. (PI); Tian, L. (PI)

BIOMEDIN 390C: Curricular Practical Training

Provides educational opportunities in biomedical informatics research. Qualified biomedical informatics students engage in internship work and integrate that work into their academic program. Students register during the quarter they are employed and must complete a research report outlining their work activity, problems investigated, key results, and any follow-up on projects they expect to perform. BIOMEDIN 390A, B, and C may each be taken only once.
Terms: Aut, Win, Spr, Sum | Units: 1
Instructors: ; Musen, M. (PI); Tian, L. (PI)

BIOMEDIN 432: Analysis of Costs, Risks, and Benefits of Health Care (HRP 392)

For graduate students. How to do cost/benefit analysis when the output is difficult or impossible to measure. Literature on the principles of cost/benefit analysis applied to health care. Critical review of actual studies. Emphasis is on the art of practical application.
Terms: Aut | Units: 4

BIOMEDIN 472: Data science and AI for COVID-19 (BIODS 472, CS 472)

This project class investigates and models COVID-19 using tools from data science and machine learning. We will introduce the relevant background for the biology and epidemiology of the COVID-19 virus. Then we will critically examine current models that are used to predict infection rates in the population as well as models used to support various public health interventions (e.g. herd immunity and social distancing). The core of this class will be projects aimed to create tools that can assist in the ongoing global health efforts. Potential projects include data visualization and education platforms, improved modeling and predictions, social network and NLP analysis of the propagation of COVID-19 information, and behavior-nudging tools. The class is aimed toward students with experience in data science and AI, and will include guest lectures by biomedical experts. Prerequisites: background in machine learning and statistics (CS229, STATS216 or equivalent). Some biological background is helpful but not required.
Last offered: Spring 2020 | Units: 2

BIOMEDIN 801: TGR Master's Project

Project credit for masters students who have completed all course requirements and minimum of 45 Stanford units.
Terms: Aut, Win, Spr, Sum | Units: 0 | Repeatable for credit
Instructors: ; Altman, R. (PI); Ashley, E. (PI); Bassik, M. (PI); Batzoglou, S. (PI); Bayati, M. (PI); Bejerano, G. (PI); Bhattacharya, J. (PI); Blish, C. (PI); Boahen, K. (PI); Brandeau, M. (PI); Brutlag, D. (PI); Bustamante, C. (PI); Butte, A. (PI); Chang, H. (PI); Cherry, J. (PI); Cohen, S. (PI); Covert, M. (PI); Curtis, C. (PI); Das, A. (PI); Das, R. (PI); Davis, R. (PI); Delp, S. (PI); Desai, M. (PI); Dill, D. (PI); Dumontier, M. (PI); Elias, J. (PI); Fagan, L. (PI); Feldman, M. (PI); Ferrell, J. (PI); Fraser, H. (PI); Gentles, A. (PI); Gerritsen, M. (PI); Gevaert, O. (PI); Goldstein, M. (PI); Greenleaf, W. (PI); Guibas, L. (PI); Hastie, T. (PI); Hlatky, M. (PI); Holmes, S. (PI); Ji, H. (PI); Karp, P. (PI); Khatri, P. (PI); Kim, S. (PI); Kirkegaard, K. (PI); Klein, T. (PI); Koller, D. (PI); Krummel, T. (PI); Kundaje, A. (PI); Levitt, M. (PI); Li, J. (PI); Longhurst, C. (PI); Lowe, H. (PI); Mallick, P. (PI); Manning, C. (PI); McAdams, H. (PI); Menon, V. (PI); Montgomery, S. (PI); Musen, M. (PI); Napel, S. (PI); Nolan, G. (PI); Olshen, R. (PI); Owen, A. (PI); Owens, D. (PI); Paik, D. (PI); Palacios, J. (PI); Pande, V. (PI); Petrov, D. (PI); Plevritis, S. (PI); Poldrack, R. (PI); Pritchard, J. (PI); Relman, D. (PI); Riedel-Kruse, I. (PI); Rivas, M. (PI); Rubin, D. (PI); Sabatti, C. (PI); Salzman, J. (PI); Shachter, R. (PI); Shafer, R. (PI); Shah, N. (PI); Sherlock, G. (PI); Sidow, A. (PI); Snyder, M. (PI); Tang, H. (PI); Taylor, C. (PI); Theriot, J. (PI); Tibshirani, R. (PI); Tu, S. (PI); Utz, P. (PI); Walker, M. (PI); Wall, D. (PI); Winograd, T. (PI); Wong, W. (PI); Xing, L. (PI); Zou, J. (PI)

BIOMEDIN 802: TGR PhD Dissertation

Terms: Aut, Win, Spr, Sum | Units: 0 | Repeatable for credit
Instructors: ; Altman, R. (PI); Ashley, E. (PI); Baiocchi, M. (PI); Bassik, M. (PI); Batzoglou, S. (PI); Bayati, M. (PI); Bejerano, G. (PI); Bhattacharya, J. (PI); Blish, C. (PI); Boahen, K. (PI); Brandeau, M. (PI); Brutlag, D. (PI); Bustamante, C. (PI); Butte, A. (PI); Chang, H. (PI); Cherry, J. (PI); Cohen, S. (PI); Covert, M. (PI); Curtis, C. (PI); Das, A. (PI); Das, R. (PI); Davis, R. (PI); Delp, S. (PI); Desai, M. (PI); Dill, D. (PI); Dumontier, M. (PI); Elias, J. (PI); Fagan, L. (PI); Feldman, M. (PI); Ferrell, J. (PI); Fraser, H. (PI); Gerritsen, M. (PI); Gevaert, O. (PI); Goldstein, M. (PI); Greenleaf, W. (PI); Guibas, L. (PI); Hastie, T. (PI); Hlatky, M. (PI); Holmes, S. (PI); Ji, H. (PI); Karp, P. (PI); Khatri, P. (PI); Kim, S. (PI); Kirkegaard, K. (PI); Klein, T. (PI); Koller, D. (PI); Krummel, T. (PI); Kundaje, A. (PI); Levitt, M. (PI); Li, J. (PI); Longhurst, C. (PI); Lowe, H. (PI); Mallick, P. (PI); Manning, C. (PI); McAdams, H. (PI); Menon, V. (PI); Montgomery, S. (PI); Musen, M. (PI); Napel, S. (PI); Nolan, G. (PI); Olshen, R. (PI); Owen, A. (PI); Owens, D. (PI); Paik, D. (PI); Palacios, J. (PI); Pande, V. (PI); Petrov, D. (PI); Plevritis, S. (PI); Poldrack, R. (PI); Pritchard, J. (PI); Relman, D. (PI); Riedel-Kruse, I. (PI); Rivas, M. (PI); Rubin, D. (PI); Sabatti, C. (PI); Salzman, J. (PI); Shachter, R. (PI); Shafer, R. (PI); Shah, N. (PI); Sherlock, G. (PI); Sidow, A. (PI); Snyder, M. (PI); Tang, H. (PI); Taylor, C. (PI); Theriot, J. (PI); Tibshirani, R. (PI); Tu, S. (PI); Utz, P. (PI); Walker, M. (PI); Wall, D. (PI); Winograd, T. (PI); Wong, W. (PI); Xing, L. (PI); Zou, J. (PI)

CS 272: Introduction to Biomedical Informatics Research Methodology (BIOE 212, BIOMEDIN 212, GENE 212)

Capstone Biomedical Informatics (BMI) experience. Hands-on software building. Student teams conceive, design, specify, implement, evaluate, and report on a software project in the domain of biomedicine. Creating written proposals, peer review, providing status reports, and preparing final reports. Issues related to research reproducibility. Guest lectures from professional biomedical informatics systems builders on issues related to the process of project management. Software engineering basics. Because the team projects start in the first week of class, attendance that week is strongly recommended. Prerequisites: BIOMEDIN 210 or 214 or 215 or 217 or 260. Preference to BMI graduate students. Consent of instructor required.
Terms: Spr | Units: 3-5

GENE 212: Introduction to Biomedical Informatics Research Methodology (BIOE 212, BIOMEDIN 212, CS 272)

Capstone Biomedical Informatics (BMI) experience. Hands-on software building. Student teams conceive, design, specify, implement, evaluate, and report on a software project in the domain of biomedicine. Creating written proposals, peer review, providing status reports, and preparing final reports. Issues related to research reproducibility. Guest lectures from professional biomedical informatics systems builders on issues related to the process of project management. Software engineering basics. Because the team projects start in the first week of class, attendance that week is strongly recommended. Prerequisites: BIOMEDIN 210 or 214 or 215 or 217 or 260. Preference to BMI graduate students. Consent of instructor required.
Terms: Spr | Units: 3-5
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