Results for tissue engineering

In this course we will learn how plants are built at different organizational scales from the cell, tissue, organ and organ system level. We will also learn about the experimental methods used to study plants at these different organizational levels and how to interpret and evaluate experiments that use such methods. Finally, advances in genetic engineering will be discussed as a means of manipulating the form and function of plants for sustainable agriculture. Broadly relevant skills that will be cultivated in the course include: evaluating primarily literature, identifying gaps in knowledge, formulating research questions and designing new experimental strategies. Prerequisites: BIO 80 series or equivalent.

In this course we will learn how plants are built at different organizational scales from the cell, tissue, organ and organ system level. We will also learn about the experimental methods used to study plants at these different organizational levels and how to interpret and evaluate experiments that use such methods. Finally, advances in genetic engineering will be discussed as a means of manipulating the form and function of plants for sustainable agriculture. Broadly relevant skills that will be cultivated in the course include: evaluating primarily literature, identifying gaps in knowledge, formulating research questions and designing new experimental strategies. Prerequisites: BIO 80 series or equivalent.

An introduction to techniques in genetic, molecular, biochemical, cellular and tissue engineering. Lectures cover advances in the field of synthetic biology with emphasis on genetic engineering, plasmid design, gene synthesis, genetic circuits, and safety and bioethics. Lab modules will teach students how to conduct basic lab techniques, add/remove DNA from living matter, and engineer prokaryotic and eukaryotic cells. Team projects will support practice in component engineering with a focus on molecular design and quantitative analysis of experiments, device and system engineering using abstracted genetically encoded objects, and product development. Concurrent or previous enrollment in BIO 82 or BIO 83. Preference to declared BioE students. Students who have not declared BioE should email Alex Engel to get on a waitlist for a permission code to enroll. Class meets in Shriram 112, lab meets in Shriram 114. Scientific Method and Analysis (SMA).

Physiology of intact human tissues, organs, and organ systems in health and disease, and bioengineering tools used (or needed) to probe and model these physiological systems. Topics: Clinical physiology, network physiology and system design/plasticity, diseases and interventions (major syndromes, simulation, and treatment, instrumentation for intervention, stimulation, diagnosis, and prevention), and new technologies including tissue engineering and optogenetics. Discussions of pathology of these systems in a clinical-case based format, with a view towards identifying unmet clinical needs. Learning computational skills that not only enable simulation of these systems but also apply more broadly to biomedical data analysis. Prerequisites: CME 102; PHYSICS 41; BIO 82 OR 83; BIO 84. CS 106A or programming experience highly recommended.

ONLINE Offering of BIOE 103. This pilot class, BIOE103B, is an entirely online offering with the same content, learning goals, and prerequisites as BIOE 103. The class is open to BioE-declared students who are not on campus in the spring. Students attend class by watching videos and completing assignments remotely. Physiology of intact human tissues, organs, and organ systems in health and disease, and bioengineering tools used (or needed) to probe and model these physiological systems. Topics: Clinical physiology, network physiology and system design/plasticity, diseases and interventions (major syndromes, simulation, and treatment, instrumentation for intervention, stimulation, diagnosis, and prevention), and new technologies including tissue engineering and optogenetics. Discussions of pathology of these systems in a clinical case-based format, with a view towards identifying unmet clinical needs. Learning computational skills that not only enable simulation of these systems but also apply more broadly to biomedical data analysis. Prerequisites: CME 102; PHYSICS 41; BIO 82 OR 83; BIO 84. CS 106A or programming experience highly recommended.

Principles of tissue engineering and design strategies for practical applications for tissue repair. Topics include tissue morphogenesis, stem cells, biomaterials, controlled drug and gene delivery, and paper discussions. Students will learn skills for lab research through interactive lectures, paper discussions and research proposal development. Students work in small teams to work on develop research proposal for authentic tissue engineering problems. Lab sessions will teach techniques for culturing cells in 3D, as well as fabricating and characterizing hydrogels as 3D cell niche.

3D bioprinting promises engineered tissues with precise structure, composition, and cellular architecture. This biofabrication technology lies at the interface of biology, bioengineering, materials science, and instrumentation. This course will teach some of the latest technologies through fundamental lectures and hands-on 3D bioprinting workshops. Student groups will embark on independent projects to innovate in any aspect or application of 3D bioprinting hardware, wetware, or software. Experience in tissue engineering ( BIOE260), instrumentation ( BIOE123), or biomaterials ( MATSCI 381) is helpful but not required.

Materials design and engineering for regenerative medicine. How materials interact with cells through their micro- and nanostructure, mechanical properties, degradation characteristics, surface chemistry, and biochemistry. Examples include novel materials for drug and gene delivery, materials for stem cell proliferation and differentiation, and tissue engineering scaffolds. Prerequisites: undergraduate chemistry, and cell/molecular biology or biochemistry.

Bioengineering department labs at Stanford present recent research projects and results. Guest lecturers. Topics include applications of engineering to biology, medicine, biotechnology, and medical technology, including biodesign and devices, molecular and cellular engineering, regenerative medicine and tissue engineering, biomedical imaging, and biomedical computation.

Soft matter comes in many forms and includes polymeric materials, suspensions, emulsions, foams, gels, and living tissue. These materials are characterized by being easily deformed and possessing internal relaxation time spectra. They are viscoelastic with responses that are intermediate between purely viscous liquids and perfectly elastic solids. This course provides an introduction to the subject of rheology, which concerns the deformation and flow of complex liquids and solids. Rheological testing is aimed at determining the relationships between the applied stresses in these materials and the resulting deformations. These are characterized by material functions, such as viscosity (shear and extensional), moduli, and compliances. These functions reflect the microstructure of the material being tested and microstructural models of polymers (single chain theories and reptation-based models), suspensions, emulsions, and foams will be presented. Experimental methods to measure materials subjected to both shearing and elongational deformations will be described. Many soft matter systems are influenced by interfacial phenomena (foams, emulsions, thin films in the human body) and interfacial rheological techniques will be discussed. Advanced undergraduates register for 170X; graduates register for 470. Prerequisites: ChE 120A or its equivalent (concurrent enrollment is permissible)

Advanced topics course examining the role of physical forces in shaping living cells, tissues, and organs, making use of D'Arcy Thompson's classic text On Growth and Form. The course begins with a review of relevant physical principles drawn from statistical physics, polymer theory, rheology and materials science. We then examine current knowledge of cellular mechanotransduction pathways, the roles of physical forces in guiding embryonic development, and the contribution of aberrant cellular response to mechanical cues in heart disease and cancer. The course concludes by examining current frontiers in stem cell biology and tissue engineering.

Soft matter comes in many forms and includes polymeric materials, suspensions, emulsions, foams, gels, and living tissue. These materials are characterized by being easily deformed and possessing internal relaxation time spectra. They are viscoelastic with responses that are intermediate between purely viscous liquids and perfectly elastic solids. This course provides an introduction to the subject of rheology, which concerns the deformation and flow of complex liquids and solids. Rheological testing is aimed at determining the relationships between the applied stresses in these materials and the resulting deformations. These are characterized by material functions, such as viscosity (shear and extensional), moduli, and compliances. These functions reflect the microstructure of the material being tested and microstructural models of polymers (single chain theories and reptation-based models), suspensions, emulsions, and foams will be presented. Experimental methods to measure materials subjected to both shearing and elongational deformations will be described. Many soft matter systems are influenced by interfacial phenomena (foams, emulsions, thin films in the human body) and interfacial rheological techniques will be discussed. Advanced undergraduates register for 170X; graduates register for 470. Prerequisites: ChE 120A or its equivalent (concurrent enrollment is permissible)

What is a nude mouse and why is it used in cancer research? Why do my mouse pups have a different coat color than their parents? What is a knockout mouse? Answers to these and more are in this introduction to the laboratory mouse, one of the most widely used models in biomedical research. We will explore the natural history and origin of the laboratory mouse; the ethics and regulations on the use of mice in research; the characteristics and nomenclature of commonly used mouse strains; the anatomy, physiology, and husbandry of mice; common mouse diseases and their effects on research; mouse coat color genetics and its relevance to human diseases; immunodeficient mouse models and their uses in research; and the technology for genetically engineering mice (e.g., transgenic mice). Hands-on laboratories will include mouse handling and biometeorology, necropsy and tissue sampling and anesthesia and surgery. Each student is expected to read research papers that use the mouse as a research model and give a presentation on a topic of their choice. Students interested in human or veterinary medicine and/or a career in biomedical research will benefit from this seminar. Class is limited to 12 students.

Integrating electronics with sensing, stimulation, and locomotion capabilities into the body will allow us to restore or enhance physiological functions. In order to be able to insert these electronics into the body, energy source is a major obstacle. This course focuses on the analysis and design of wirelessly powered catheter-deliverable electronics. Emphases will be on the interaction between human and electromagnetic fields in order to transfer power to the embedded electronics via electromagnetic fields, power harvesting circuitry, electrical-tissue interface, and sensing and actuating frontend designs.

Preference to freshmen. Real-world examples of materials developed for tissue engineering and regenerative medicine therapies. How scientists and engineers design new materials for surgeons to use in replacing body parts such as damaged heart or spinal cord tissue. How cells interact with implanted materials. Students identify a clinically important disease or injury that requires a better material, proposed research approaches to the problem, and debate possible engineering solutions.

Materials design and engineering for regenerative medicine. How materials interact with cells through their micro- and nanostructure, mechanical properties, degradation characteristics, surface chemistry, and biochemistry. Examples include novel materials for drug and gene delivery, materials for stem cell proliferation and differentiation, and tissue engineering scaffolds. Prerequisites: undergraduate chemistry, and cell/molecular biology or biochemistry.

Understanding the role of mechanics in brain development, physiology, and pathology. Mechanics of brain cells: neurons, mechanobiology, mechanotransduction. Mechanics of brain tissue: experimental testing, constitutive modeling, computational modeling. Mechanics of brain development: gyrification, cortical folding, axon elongation, lissencephaly, polymicrogyria. Mechanics of traumatic brain injury: high impact loading, neural injury. Mechanics of brain tumors, brain cancer, tumor growth, altered cytoskeletal mechanics. Mechanics of neurological disorders: autism, dementia, schizophrenia. Mechanics of brain surgery.

Mechanical cues play a critical role in development, normal functioning of cells and tissues, and various diseases. This course will cover what is known about cellular mechanotransduction, or the processes by which living cells sense and respond to physical cues such as physiological forces or mechanical properties of the tissue microenvironment. Experimental techniques and current areas of active investigation will be highlighted. This class is for graduate students only.

Introduction to the mechanical analysis of tissues (biomechanics), and how mechanical cues play a role in regulating tissue development, adaptation, regeneration, and aging (mechanobiology). Topics include tissue viscoelasticity, cardiovascular biomechanics, blood rheology, interstitial flow, bone mechanics, muscle contraction and mechanics, and mechanobiology of the musculoskeletal system. Undergraduates should have taken ME70 and ME80, or equivalent courses.

Introduction to the mechanical behaviors of biological tissues in health and disease. Overview of experimental approaches to evaluating tissue properties and mathematical constitutive models. Elastic behaviors of hard tissues, nonlinear elastic and viscoelastic models for soft tissues.

Principles of tissue engineering and design strategies for practical applications for tissue repair. Topics include tissue morphogenesis, stem cells, biomaterials, controlled drug and gene delivery, and paper discussions. Students will learn skills for lab research through interactive lectures, paper discussions and research proposal development. Students work in small teams to work on develop research proposal for authentic tissue engineering problems. Lab sessions will teach techniques for culturing cells in 3D, as well as fabricating and characterizing hydrogels as 3D cell niche.

Biological principles underlying the use of engineering strategies and biocompatible materials for tissue repair and regeneration. Structure, physiology, and mechanics of articular cartilage, bone, and dense soft connective tissues. Current ideas, approaches, and applications being implemented as therapeutic regimens for arthritis, spinal deformities, and limb salvage. Multidisciplinary constraints on the design and creation of tissue constructs. Students enrolling for 2 units prepare a presentation and final project. Prerequisite: familiarity with basic cell and molecular mechanisms underlying tissue differentiation.

Review of arts on human anatomy followed by review of modern medical knowledge on human body, disease prevention, and tissue regeneration. How interdisciplinary research (biology, engineering and medicine) is critical in advancing modern medicine. Lectures alternate with case studies and paper discussions on selected papers targeting treatment of various diseases. Develop an NIH style research proposal to solve a real-life disease problem. Introduction into the field of tissue regeneration using interdisciplinary approaches, sharpening critical paper reading and scientific writing skills, and integrating with the unique local art and research resources that Paris has to offer. In English. Students applying to the STEM/Pre-med track are expected to have taken some prior STEM courses at Stanford to demonstrate their interest and preparation for applying to this track. This course meets the STEM track requirement for the Paris Program during Winter Quarter 2019-2020.

Can brains be repaired just like cars or roads? The thought of repairing brains or enhancing them has been a dream of ideal medicine, but is it possible now? To answer that question we need to dive into NeuroEngineering. We will learn the basics of synapse and neural network formation, focusing on neural enhancement and neural repair/regeneration. Through the lenses of tissue, chemical and electrical engineering, we will learn the challenges of repairing/enhancing the brain. We'll also discuss the ethical and political implications. Grounded in Neuroscience, we'll research the latest clinical trials and technology to repair the brain.

Preference to sophomores. Biological aspects of cell and organ transplantation, including issues that arise in the popular media. Diseases for which transplantation is a treatment, the state of the art in human transplantation, transplantation of animal tissue into humans (xenotransplantation), development of new tissue and organs in the laboratory (tissue engineering and cloning), and development of drugs and biological strategies to promote long-term survival of the tissue or organ (tolerance). How to write a scientific abstract, critique scientific literature, and research and present topics in contemporary transplantation.

The surgical anatomy of the hand is extremely complex in terms of structure and function. Exploration of the anatomy of the hand in different contexts: its representation in art forms, the historical development of the study of hand anatomy, current operative techniques for reconstruction, advances in tissue engineering, and the future of hand transplantation.