ME 450: Advances in Biotechnology
Guest academic and industrial speakers. Latest developments in fields such as bioenergy, green process technology, production of industrial chemicals from renewable resources, protein pharmaceutical production, industrial enzyme production, stem cell applications, medical diagnostics, and medical imaging. Biotechnology ethics, business and patenting issues, and entrepreneurship in biotechnology.
Terms: not given next year

Units: 3

Grading: Letter or Credit/No Credit
ME 451A: Advanced Fluid Mechanics Multiphase Flows
Single particle and multiparticle fluid flow phenomena, mass, momentum and heat transfer, characteristic time and length scales, nondimensional groups; collection of dispersedphase elements: instantaneous and averaged descriptions for multiphase flow, EulerianEulerian and LagrangianEulerian statistical representations, mixture theories; models for drag, heat and mass transfer; dilute to dense twophase flow, granular flows; computer simulation approaches for multiphase flows, emerging research topics. Prerequisites: graduate level fluid mechanics and engineering mathematics, and undergraduate engineering mechanics and thermodynamics.
Terms: Aut

Units: 3

Grading: Letter or Credit/No Credit
Instructors:
Ihme, M. (PI)
ME 451B: Advanced Fluid Mechanics Flow Instability
Waves in fluids: surface waves, internal waves, inertial and acoustic waves, dispersion and group velocity, wave trains, transport due to waves, propagation in slowly varying medium, wave steepening, solitons and solitary waves, shock waves. Instability of fluid motion: dynamical systems, bifurcations, KelvinHelmholtz instability, RayleighBenard convection, energy method, global stability, linear stability of parallel flows, necessary and sufficient conditions for stability, viscosity as a destabilizing factor, convective and absolute instability. Focus is on flow instabilities. Prerequisites: graduate courses in compressible and viscous flow.
Terms: Aut

Units: 3

Grading: Letter or Credit/No Credit
Instructors:
Lele, S. (PI)
ME 451C: Advanced Fluid Mechanics
Compressible flow: governing equations, CroccoVazsonyi¿s equations, creation and destruction of vorticity by compressibility effects, shock waves. Modal decomposition of compressible flow, linear and nonlinear modal interactions, interaction of turbulence with shock waves. Energetics of compressible turbulence, effects of compressibility on freeshear flows, turbulent boundary layers, Van Direst transformation, recovery temperature, and shock/boundary layer interaction. Strong Reynolds analogy, modeling compressible turbulent flows. Prerequisites: 355, 361A, or equivalents.
Terms: not given this year

Units: 3

Grading: Letter (ABCD/NP)
ME 451D: Microhydrodynamics (CHEMENG 310)
Transport phenomena on smalllength scales appropriate to applications in microfluidics, complex fluids, and biology. The basic equations of mass, momentum, and energy, derived for incompressible fluids and simplified to the slowflow limit. Topics: solution techniques utilizing expansions of harmonic and Green's functions; singularity solutions; flows involving rigid particles and fluid droplets; applications to suspensions; lubrication theory for flows in confined geometries; slender body theory; and capillarity and wetting. Prerequisites: 120A,B, 300, or equivalents.
Terms: Win

Units: 3

Grading: Letter or Credit/No Credit
Instructors:
Fuller, G. (PI)
ME 453A: Finite ElementBased Modeling and Simulation of Linear Fluid/Structure Interaction Problems
Basic physics behind many fluid/structure interaction phenomena. Finite elementbased computational approaches for linear modeling and simulation in the frequency domain. Vibrations of elastic structures. Linearized equations of small movements of inviscid fluids. Sloshing modes. Hydroelastic vibrations. Acoustic cavity modes. Structuralacoustic vibrations. Applications to liquid containers and underwater signatures. Prerequisite: graduate course in the finite element method or consent of instructor.
Terms: not given this year

Units: 3

Grading: Letter or Credit/No Credit
ME 453B: Computational Fluid Dynamics Based Modeling of Nonlinear Fluid/Structure Interaction Problems
Basic physics behind many highspeed flow/structure interaction phenomena. Modern computational approaches for nonlinear modeling and simulation in the time domain. Dynamic equilibrium of restrained and unrestrained elastic structures. Corotational formulation for large structural displacements and rotations. Arbitrary LagrangianEulerian description of inviscid and viscous flows. Timeaccurate CFD on moving and deforming grids. Discrete geometric conservation laws. Discretization of transmission conditions on nonmatching discrete fluid/structure interfaces. Coupled fluid/meshmotion/structure time integration schemes. Application to divergence, flutter, and buffeting. Prerequisites: graduate course in the finite element method, and in computational fluid dynamics.
Terms: not given this year

Units: 3

Grading: Letter or Credit/No Credit
ME 455: Complex Fluids and NonNewtonian Flows (CHEMENG 462)
Definition of a complex liquid and microrheology. Division of complex fluids into suspensions, solutions, and melts. Suspensions as colloidal and noncolloidal. Extra stress and relation to the stresslet. Suspension rheology including Brownian and nonBrownian fibers. Microhydrodynamics and the FokkerPlanck equation. Linear viscoelasticity and the weak flow limit. Polymer solutions including single mode (dumbbell) and multimode models. Nonlinear viscoelasticity. Intermolecular effects in nondilute solutions and melts and the concept of reptation. Prerequisites: low Reynolds number hydrodynamics or consent of instructor.
Terms: not given this year

Units: 3

Grading: Letter (ABCD/NP)
ME 457: Fluid Flow in Microdevices
Physicochemical hydrodynamics. Creeping flow, electric double layers, and electrochemical transport such as NernstPlanck equation; hydrodynamics of solutions of charged and uncharged particles. Device applications include microsystems that perform capillary electrophoresis, drug dispension, and hybridization assays. Emphasis is on bioanalytical applications where electrophoresis, electroosmosis, and diffusion are important. Prerequisite: consent of instructor.
Terms: not given this year

Units: 3

Grading: Letter or Credit/No Credit
ME 458: Advanced Topics in Electrokinetics
Electrokinetic theory and electrokinetic separation assays. Electroneutrality approximation and weak electrolyte electrophoresis theory. Capillary zone electrophoresis, field amplified sample stacking, isoelectric focusing, and isotachophoresis. Introduction to general electrohydrodynamics (EHD) theory including the leaky dielectric concept, the Ohmic model formulation, and electrokinetic flow instabilities. Prerequisite:
ME 457.
Terms: Spr

Units: 35

Grading: Letter (ABCD/NP)
Instructors:
Santiago, J. (PI)
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