1 - 10 of 21 results for: CSB

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

The molecular mechanisms through which cells receive and respond to external signals. Emphasis is on principles of cell signaling, the systems-level properties of signal transduction modules, and experimental strategies through which cell signaling pathways are being studied. Prerequisite: working knowledge of biochemistry and genetics.

The principles of organic and physical chemistry applied to biomolecules. The goal is a working knowledge of chemical principles that underlie biological processes. Chemical tools and techniques used to study and manipulate biological systems may be used to illustrate these principles. Prerequisites: organic chemistry and biochemistry, or consent of instructor.

Biological light microscopy: from theory to practice. This intensive laboratory and lecture course will provide participants with the theoretical and practical knowledge to utilize emerging imaging technologies. Students will learn the principles of light microscopy, as well as use of different types of cameras, laser scanning systems, functional fluorophores, probe delivery techniques. Topics include microscope optics, resolution limits, Koehler illumination, confocal fluorescence, two-photon, TIRF, FRET, photobleaching, super-resolution (SIM, STED, STORM/PALM), and live-cell imaging and cell tracking approaches. Discussion of physical principles; involves partial assembly and extensive use of lab instruments. Lab. Prerequisites: some college physics.

Required of and limited to all graduate students and postdoctoral scholar in the Department of Chemical and Systems Biology. Students and postdocs are required to give in-depth presentations about their current projects within the academic year.

Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Maximum units are available by taking an additional contact hour.

(Continuation of 240A) Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Maximum units are available by taking an additional contact hour. Prerequisite: 240A.

The scientific principles and technologies involved in making the transition from a basic biological observation to the creation of a new drug emphasizing molecular and genetic issues. Prerequisite: biochemistry, chemistry, or bioengineering.