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GENE 215: Frontiers in Biological Research (BIOC 215, DBIO 215)

Literature discussion in conjunction with the Frontiers in Biological Research seminar series hosted by Biochemistry, Developmental Biology, and Genetics in which distinguished investigators present current work. Students and faculty meet beforehand to discuss papers from the speaker's primary research literature. Students meet with the speaker after the seminar to discuss their research and future direction, commonly used techniques to study problems in biology, and comparison between the genetic and biochemical approaches in biological research.
Terms: Aut, Win | Units: 1 | Repeatable 3 times (up to 3 units total)

GENE 221: Current Issues in Aging (DBIO 221)

Current research literature on genetic mechanisms of aging in animals and human beings. Topics include: mitochondria mutations, insulin-like signaling, sirtuins, aging in flies and worms, stem cells, human progeria, and centenarian studies. Prerequisite: GENE 203.
Terms: Spr | Units: 2

GENE 222: Method and Logic in Experimental Genetics

For graduate students only. How experimental strategies are applied to biological questions irrespective of discipline boundaries. Examples include purifying activities from complex mixtures, localizing molecules in space and time, discovering macromolecular interactions, inferences from sequence similarity, using structure to elucidate function, and applying genomics to biological problems. Weekly discussion of two representative papers selected by faculty and a student presentation of a third paper which illustrate principles of biochemistry and cell and molecular biology, and the historical context of important scientific advances.
Terms: Win | Units: 3

GENE 233: The Biology of Small Modulatory RNAs (MI 233, PATH 233)

Open to graduate and medical students. How recent discoveries of miRNA, RNA interference, and short interfering RNAs reveal potentially widespread gene regulatory mechanisms mediated by small modulatory RNAs during animal and plant development. Required paper proposing novel research.
Terms: Aut | Units: 2

GENE 234: Fundamentals of RNA Biology (MI 234, PATH 234)

For graduate or medical students and (if space allows) to active participants from other segments of the Stanford Community (e.g., TGR students); undergraduates by instructor consent. Fundamental issues of RNA biology, with the goal of setting a foundation for students to explore the expanding world of RNA-based regulation. Each week a topic is covered by a faculty lecture and journal club presentations by students.
Terms: Aut | Units: 2

GENE 235: C. Elegans Genetics

Genetic approaches to C. elegans, practice in designing experiments and demonstrations of its growth and anatomy. Probable topics include: growth and genetics, genome map and sequence, mutant screens that start with a desired phenotype, reverse genetics and RNAi screens, genetic duplications, uses of null phenotype non-null alleles, genetic interactions and pathway analysis, and embryogenesis and cell lineage. Focus of action, mosaic analysis, and interface with embryological and evolutionary approaches.
Terms: Win | Units: 2
Instructors: Fire, A. (PI)

GENE 243: Scientific Evidence and Expert Testimony: Patent Litigation

Open to clinical MD and graduate students. How to explain science to judge and jury; how litigators determine which legal issues to argue. Patent and expert testimony law. Student teams choose patents for final simulation projects, prepare claim charts, devise a design-around, and present simulations of expert testimony. Prerequisite: Graduate students must have completed all coursework in their departments for the PhD degree.
Terms: Aut | Units: 3
Instructors: Morris, R. (PI)

GENE 245: Computational Algorithms for Statistical Genetics (STATS 345)

Computational algorithms for human genetics research. Topics include: permutation, bootstrap, expectation maximization, hidden Markov model, and Markov chain Monte Carlo. Rationales and techniques illustrated with existing implementations commonly used in population genetics research, disease association studies, and genomics analysis. Prerequisite: GENE 244 or consent of instructor.
Last offered: Spring 2009

GENE 260: Supervised Study

Genetics graduate student lab research from first quarter to filing of candidacy. Prerequisite: consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit

GENE 271: Human Molecular Genetics

For genetic counseling students, graduate students in genetics, medical students, residents, and postdoctoral fellows interested in the practice of medical genetics. Gene structure and function; the impact of mutation and polymorphism as they relate to developmental pathways and health and human disease; population based genetics; approaches to the study of complex genetic conditions, and gene therapy, proteomics, stem cell biology, and pharmacogenetics. Undergraduates require consent of instructor and a basic genetics course.
Terms: Aut | Units: 4
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