NENS 67N: Intracellular Trafficking and Neurodegeneration
Preference to freshmen. Cell structures and functions, the intracellular trafficking system that maintains exchanges of materials and information inside cells, and clinical features and pathologies of neurodegenerative diseases. Techniques for examining cellular and subcellular structures, especially cytoskeletons; functional insights generated from structural explorations. Prerequisite: high school biology.
Terms: Spr

Units: 3

UG Reqs: WAYSMA

Grading: Letter or Credit/No Credit
Instructors:
Yang, Y. (PI)
NENS 202: Longevity (HUMBIO 149L, PSYCH 102)
Interdisciplinary. Challenges to and solutions for the young from increased human life expectancy: health care, financial markets, families, work, and politics. Guest lectures from engineers, economists, geneticists, and physiologists.
Terms: alternate years, given next year

Units: 4

Grading: Medical Option (MedLtrCR/NC)
NENS 199: Undergraduate Research
Students undertake research sponsored by an individual faculty member. Prerequisite: consent of instructor.
Terms: Aut, Win, Spr, Sum

Units: 118

Repeatable for credit

Grading: Letter or Credit/No Credit
Instructors:
Albers, G. (PI)
;
Andreasson, K. (PI)
;
BronteStewart, H. (PI)
...
more instructors for NENS 199 »
Instructors:
Albers, G. (PI)
;
Andreasson, K. (PI)
;
BronteStewart, H. (PI)
;
Buckwalter, M. (PI)
;
Cho, S. (PI)
;
Cho, Y. (PI)
;
Cowan, R. (PI)
;
Day, J. (PI)
;
Dorfman, L. (PI)
;
Duane, D. (PI)
;
Dunn, J. (PI)
;
Elbers, J. (PI)
;
Finley Caulfield, A. (PI)
;
Fisher, P. (PI)
;
Fisher, R. (PI)
;
Graber, K. (PI)
;
Greicius, M. (PI)
;
Hahn, J. (PI)
;
Han, M. (PI)
;
Hotson, J. (PI)
;
Huang, T. (PI)
;
Huguenard, J. (PI)
;
Jaradeh, S. (PI)
;
Kerchner, G. (PI)
;
Lansberg, M. (PI)
;
Lee, L. (PI)
;
Longo, F. (PI)
;
Lopez, J. (PI)
;
McQuillen, M. (PI)
;
MonjeDeisseroth, M. (PI)
;
Olivot, J. (PI)
;
Olson, D. (PI)
;
Parvizi, J. (PI)
;
Poston, K. (PI)
;
Prince, D. (PI)
;
Rando, T. (PI)
;
Recht, L. (PI)
;
Reimer, R. (PI)
;
Schwartz, N. (PI)
;
So, Y. (PI)
;
Steinman, L. (PI)
;
Venkatasubramanian, C. (PI)
;
Wijman, C. (PI)
;
WyssCoray, T. (PI)
;
Yang, Y. (PI)
NENS 205: Neurobiology of Disease Seminar
Case demonstrations of selected disorders, discussion of the pathophysiological basis of the disorder, presentation of the basic principles underlying modern diagnostic and therapeutic management, and a discussion of recent research advances for each disease entity. Prerequisite: Neurobiology 206 or consent of instructor.
Terms: Win

Units: 3

Grading: Medical Option (MedLtrCR/NC)
Instructors:
Andreasson, K. (PI)
;
Yang, Y. (PI)
NENS 206: Introduction to Neurology Seminar
Exploration of aspects of neurology, including subspecialties. Current issues, clinical cases, and opportunities in the field.
Terms: Aut

Units: 1

Repeatable for credit

Grading: Medical Satisfactory/No Credit
Instructors:
Nguyen, V. (PI)
;
Reimer, R. (PI)
NENS 207: Neuroscience Core Curriculum: Translational Neuroscience
Emphasis on basic and preclinical research in selected categories of neurological disease, and understanding how these discoveries are being translated into therapies. Readings include primary scientific literature in mechanisms of disease and translational approaches and selected current reviews. Enrollment limited to 20 students. For first year Neuroscience graduate students, open to other graduate students as space permits with preference given to Neurosciences students .
Terms: Spr

Units: 1

Grading: Letter (ABCD/NP)
Instructors:
Andreasson, K. (PI)
;
Yang, Y. (PI)
NENS 220: Computational Neuroscience
Computational approaches to neuroscience applied at levels ranging from neurons to networks. Addresses two central questions of neural computation: How do neurons compute; and how do networks of neurons encode/decode and store information? Focus is on biophysical (HodgkinHuxley) models of neurons and circuits, with emphasis on application of commonly available modeling tools (NEURON, MATLAB) to issues of neuronal and network excitability. Issues relevant to neural encoding and decoding, information theory, plasticity, and learning. Fundamental concepts of neuronal computation; discussion focus is on relevant literature examples of proper application of these techniques. Final project. Recommended for Neuroscience Program graduate students; open to graduate, medical, and advanced undergraduate students with consent of instructor. Prerequisite:
NBIO 206. Recommended: facility with linear algebra and calculus.
Terms: not given this year

Units: 4

Grading: Medical Option (MedLtrCR/NC)
NENS 230: Analysis Techniques for the Biosciences Using MATLAB
Data analysis and visualization techniques commonly encountered in biosciences research. Fundamentals of the MATLAB computing environment, programming and debugging, data import/export, data structures, plotting, image analysis, introduction to statistical tools. Examples and assignments draw from a range of topics applicable to bioscience research: frequency analysis, genetic data mining, ion channel kinetics, neural spike rasters and spiketriggered averages, cell counting in fluorescence images, regression, PCA, and stochastic simulation. Assignments are practical in nature and demonstrate how to implement specific analyses that a biosciences student is likely to encounter.
Terms: Aut

Units: 2

Grading: Medical Satisfactory/No Credit
Instructors:
Huguenard, J. (PI)
;
Naecker, B. (PI)
;
Trautmann, E. (PI)
...
more instructors for NENS 230 »
Instructors:
Huguenard, J. (PI)
;
Naecker, B. (PI)
;
Trautmann, E. (PI)
;
Maheswaranathan, N. (SI)
;
Maheswaranathan, N. (TA)
NENS 267: Molecular Mechanisms of Neurodegenerative Disease (BIO 267)
The epidemic of neurodegenerative disorders such as Alzheimer's and Parkinson's disease occasioned by an aging human population. Genetic, molecular, and cellular mechanisms. Clinical aspects through case presentations.
Terms: alternate years, given next year

Units: 4

Grading: Medical Option (MedLtrCR/NC)
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