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1 - 10 of 17 results for: BIOPHYS

BIOPHYS 227: Functional MRI Methods (BIOE 227, BMP 227, RAD 227)

Basics of functional magnetic resonance neuroimaging, including data acquisition, analysis, and experimental design. Journal club sections. Cognitive neuroscience and clinical applications. Prerequisites: basic physics, mathematics; neuroscience recommended.
Last offered: Spring 2023

BIOPHYS 232: Advanced Imaging Lab in Biophysics (APPPHYS 232, BIO 132, BIO 232, BIOE 232, GENE 232)

Laboratory and lectures. Advanced microscopy and imaging, emphasizing hands-on experience with state-of-the-art techniques. Students construct and operate working apparatus. Topics include microscope optics, Koehler illumination, contrast-generating mechanisms (bright/dark field, fluorescence, phase contrast, differential interference contrast), and resolution limits. Laboratory topics vary by year, but include single-molecule fluorescence, fluorescence resonance energy transfer, confocal microscopy, two-photon microscopy, microendoscopy, and optical trapping. Limited enrollment. Recommended: basic physics, basic cell biology, and consent of instructor.
Terms: Spr | Units: 4

BIOPHYS 235: Biotransport Phenomena (APPPHYS 235, BIOE 235, ME 235)

The efficient transport of energy, mass, and momentum is essential to the normal function of living systems. Changes in these processes often result in pathological conditions. Transport phenomena are also critical to the design of instrumentation for medical applications and biotechnology. The course aims to introduce the integrated study of transport processes and their biological applications. It covers the fundamental driving forces for transport in biological systems and the biophysics across multiple length scales (molecules, cells, tissues, organs, whole organisms). Topics include chemical gradients, electrical interactions, fluid flow, mass transport. Pre-requisites: Calculus, MATLAB, basic fluid mechanics, heat transfer, solid mechanics.
Last offered: Winter 2023

BIOPHYS 241: Biological Macromolecules (BIOC 241, BIOE 241, SBIO 241)

The physical and chemical basis of macromolecular function. Topics include: forces that stabilize macromolecular structure and their complexes; thermodynamics and statistical mechanics of macromolecular folding, binding, and allostery; diffusional processes; kinetics of enzymatic processes; the relationship of these principles to practical application in experimental design and interpretation. The class emphasizes interactive learning, and is divided among lectures, in-class group problem solving, and discussion of current and classical literature. Enrollment limited to 30. Prerequisites: Background in biochemistry and physical chemistry recommended but material available for those with deficiency in these areas; undergraduates with consent of instructor only.
Terms: Aut | Units: 3-5

BIOPHYS 242: Methods in Molecular Biophysics (SBIO 242)

Experimental methods in molecular biophysics from theoretical and practical standpoints. Emphasis is on X-ray diffraction, electron microscopy, nuclear magnetic resonance, and fluorescence spectcroscopy. Prerequisite: physical chemistry or consent of instructor.
Terms: Win | Units: 3

BIOPHYS 244: Mechanotransduction in Cells and Tissues (BIOE 283, ME 244)

Mechanical cues play a critical role in development, normal functioning of cells and tissues, and various diseases. This course will cover what is known about cellular mechanotransduction, or the processes by which living cells sense and respond to physical cues such as physiological forces or mechanical properties of the tissue microenvironment. Experimental techniques and current areas of active investigation will be highlighted. This class is for graduate students only.
Terms: Aut, Win | Units: 3

BIOPHYS 250: SEMINAR IN BIOPHYSICS

Required of Biophysics graduate students. Presentation of current research projects and results by faculty in the Biophysics program. May be repeated for credit. BIOPHYS 250 is a seminar course intended only for first year Biophysics and Structural Biology graduate students, to help them decide on which faculty labs they want to settle in.
Terms: Aut | Units: 1 | Repeatable for credit

BIOPHYS 279: Computational Biology: Structure and Organization of Biomolecules and Cells (BIOE 279, BIOMEDIN 279, CME 279, CS 279)

Computational techniques for investigating and designing the three-dimensional structure and dynamics of biomolecules and cells. These computational methods play an increasingly important role in drug discovery, medicine, bioengineering, and molecular biology. Course topics include protein structure prediction, protein design, drug screening, molecular simulation, cellular-level simulation, image analysis for microscopy, and methods for solving structures from crystallography and electron microscopy data. Prerequisites: elementary programming background ( CS 106A or equivalent) and an introductory course in biology or biochemistry.
Terms: Aut | Units: 3

BIOPHYS 294: Cellular Biophysics (APPPHYS 294, BIO 294)

Physical biology of dynamical and mechanical processes in cells. Emphasis is on qualitative understanding of biological functions through quantitative analysis and simple mathematical models. Sensory transduction, signaling, adaptation, switches, molecular motors, actin and microtubules, motility, and circadian clocks. Prerequisites: differential equations and introductory statistical mechanics.
Terms: Win | Units: 3
Instructors: Fisher, D. (PI)

BIOPHYS 297: Bio-Inorganic Chemistry (CHEM 257)

(Formerly Chem 297) Overview of metal sites in biology. Metalloproteins as elaborated inorganic complexes, their basic coordination chemistry and bonding, unique features of the protein ligand, and the physical methods used to study active sites. Active site structures are correlated with function (election transfer; dioxygen binding, activation and reduction to water). Prerequisites: Chem 153 and Chem 173, or equivalents.
Last offered: Autumn 2021
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