printer friendly pageBIOE 335: Molecular Motors I
Physical mechanisms of mechanochemical coupling in biological molecular motors, using F1 ATPase as the major model system. Applications of biochemistry, structure determination, single molecule tracking and manipulation, protein engineering, and computational techniques to the study of molecular motors.
Terms: Win
| Units: 3
Instructors:
Bryant, Z. (PI)
BIOE 337: Organismic Biophysics and Living Soft-matter
Integrated physical biology; from molecules to organisms. Tree of life, diversity of life forms. Multi-scale/hierarchical systems in biophysics, Hierarchical self-organization. Basic theory of squishy materials, colloidal physics. Phase transitions in living soft-matter. Experimental techniques in soft-matter physics. Active fluid models for living matter. Design of self-assembling and self-organizing, biomimetic supramolecular systems.
Terms: Win
| Units: 3
Instructors:
Prakash, M. (PI)
;
Katsikis, G. (TA)
BIOE 355: Advanced Biochemical Engineering (CHEMENG 355)
Combines biological knowledge and methods with quantitative engineering principles. Quantitative review of biochemistry and metabolism; recombinant DNA technology and synthetic biology (metabolic engineering). The production of protein pharaceuticals as a paradigm for the application of chemical engineering principles to advanced process development within the framework of current business and regulatory requirements. Prerequisite:
CHEMENG 181 (formerly 188) or
BIOSCI 41, or equivalent.
Terms: Spr
| Units: 3
Instructors:
Swartz, J. (PI)
BIOE 36Q: The Biophysics of Innate Immunity
The innate immune system provides our first line of defense against disease--bothninfections, and cancer. Innate immune effectors such as host defense peptides arendeployed by numerous cell types (for instance neutrophils, macrophages, NK cells,nepithelial cells and keratinocytes) and work by biophysical mechanisms of action. The ourse draws from the primary literature and covers the evolution, structures, mechanisms,and physiological functions of important "innate immune effectors" (components of the innate immune system that can attack pathogens, and infected or host cells, and kill or incapacitate them directly). The course is aimed at students who have an interest in biochemistry, molecular/cellular biology, biophysics, and/or bioengineering.
BIOE 370: Microfluidic Device Laboratory
Fabrication of microfluidic devices for biological applications. Photolithography, soft lithography, and micromechanical valves and pumps. Emphasis is on device design, fabrication, and testing.
Terms: Win
| Units: 2
Instructors:
Quake, S. (PI)
;
Yu, B. (TA)
BIOE 371: Global Biodesign: Medical Technology in an International Context (MED 271)
(Same as
OIT 587) Seminar examines the development and commercialization of medical technologies in the global setting focusing primarily on Europe, India and China. Faculty and guest speakers from industry and government discuss the status of the industry, as well as opportunities in and challenges to medical technology innovation unique to each geography. Topics related to development of technologies for bottom of the pyramid markets are also addressed. Students enrolling for 3 units are required to write and deliver a final paper.
Terms: Spr
| Units: 3
| Repeatable
for credit
Instructors:
Doshi, R. (PI)
;
Mairal, A. (PI)
;
Pietzsch, J. (PI)
...
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Instructors:
Doshi, R. (PI)
;
Mairal, A. (PI)
;
Pietzsch, J. (PI)
;
Shen, C. (PI)
;
Yock, P. (PI)
;
Korir, G. (TA)
BIOE 374A: Biodesign Innovation: Needs Finding and Concept Creation (ME 368A, MED 272A)
This is the first quarter of a two-quarter course series (
OIT 384/
OIT 385). In this course, students learn how to develop comprehensive solutions (most commonly medical devices) to some of the most significant medical problems. The first quarter includes an introduction to needs finding methods, brainstorming and concept creation. Students learn strategies for understanding and interpreting clinical needs, researching literature and searching patents. Working in small entrepreneurial multidisciplinary teams, students gain exposure to clinical and scientific literature review, techniques of intellectual property analysis and feasibility, basic prototyping and market assessment. Students create, analyze and screen medical technology ideas, and select projects for future development. Final presentations at the end of the winter quarter to a panel of prominent inventors and investors in medical technology provide the impetus for further work in the spring quarter. Course format includes expert guest lecturers (Thu: 4:15 to 6:05 pm), faculty-led practical demonstrations and coaching sessions, and interactive team meetings (Tues: 4:15 to 6:05 pm). Projects from previous years included: prevention of hip fractures in the elderly; methods to accelerate healing after surgery; less invasive techniques for bariatric surgery; point of care diagnostics to improve emergency room efficiency; novel devices to bring specialty-type of care to primary care community doctors. More than 300,000 patients have been treated to date with technologies developed as part of this program and more than thirty venture-backed companies were started by alums of the program. Students must apply and be accepted into the course. The application is available online at
http://biodesign.stanford.edu/bdn/courses/bioe374.jsp.
Terms: Win
| Units: 4
BIOE 374B: Biodesign Innovation: Concept Development and Implementation (ME 368B, MED 272B)
Two-quarter sequence (see OIT384 for complete description of the sequence). The second quarter focuses on how to take a conceptual solution to a medical need forward into development and potential commercialization. Continuing work in teams with engineering and medical colleagues, students will learn the fundamentals of medical device prototyping; patent strategies; advanced planning for reimbursement and FDA approval; choosing a commercialization route (licensing vs. start-up); marketing, sales and distribution strategies; ethical issues including conflict of interest; fundraising approaches and cash requirements; financial modeling; essentials of developing a business or research plan/canvas; and strategies for assembling a development team. Final project presentations are made to a panel of prominent venture and corporate investors. New students (i.e. students who did not take OIT384 in the winter quarter) may be admitted, depending on team needs. Candidates need to submit an application at
http://biodesign.stanford.edu/bdn/courses/bioe374app.jsp by March 1.
Terms: Spr
| Units: 4
Instructors:
Yock, P. (PI)
;
Brinton, T. (SI)
;
Milroy, J. (SI)
...
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BIOE 375A: Biodesign Innovation: Needs Finding and Concept Creation
Enrollment limited to SCPD students. Two quarter sequence. Inventing new medical devices and instrumentation, including: methods of validating medical needs; techniques for analyzing intellectual property; basics of regulatory (FDA) and reimbursement planning; brainstorming and early prototyping. Guest lecturers and practical demonstrations.
Terms: Win
| Units: 2
BIOE 375B: Biodesign Innovation: Concept Development and Implementation
Enrollment limited to SCPD students. Two quarter sequence. How to take a medical device invention forward from early concept to technology translation and development. Topics include prototyping; patent strategies; advanced planning for reimbursement and FDA approval; choosing translation route (licensing versus start-up); ethical issues including conflict of interest; fundraising approaches and cash requirements; essentials of writing a business or research plan; strategies for assembling a development team. Prerequisite:
BIOE 375A
Terms: Spr
| Units: 2
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