DBIO 11N: Human Development: Egg to Embryo
Considers aspects of the developmental biology of human eggs and the first three weeks of human development. Topics include activation of sperm and eggs during the fertilization process, sperm motility and chemotaxis, cell recognition and immuno-contraception, onset of embryonic transcription, control of cell division, ethical and biological limitations to cloning, and the early establishment of pattern in the human embryo. Social and ethical concerns regarding infertility and the use of human pre-embryos in research are also considered. Readings include current review articles from medical and biological literature. Prerequisite: Advanced-placement Biology.
| UG Reqs: GER: DB-NatSci
DBIO 12Q: The Evolution and Development of the Human Hand
Evolution of the human hand in the context of primate evolution; roles of the human hand in tool use, manufacture, art, music, and communication. Development of the hand: embryonic axes, appearance of the digit program, roles of cell death, molecular bases of normal and abnormal hand patterns. Prerequisite: advanced placement biology.
DBIO 199: Undergraduate Research
Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
Terms: Aut, Win, Spr, Sum
| Units: 1-18
| Repeatable
for credit
Instructors:
Barres, B. (PI)
;
Bejerano, G. (PI)
;
Crabtree, G. (PI)
...
more instructors for DBIO 199 »
Instructors:
Barres, B. (PI)
;
Bejerano, G. (PI)
;
Crabtree, G. (PI)
;
Fuller, M. (PI)
;
Kim, S. (PI)
;
Kim, S. (PI)
;
Kingsley, D. (PI)
;
McAdams, H. (PI)
;
Nusse, R. (PI)
;
Porzig, E. (PI)
;
Scott, M. (PI)
;
Shapiro, L. (PI)
;
Talbot, W. (PI)
;
Villeneuve, A. (PI)
;
Weissman, I. (PI)
;
Wysocka, J. (PI)
DBIO 201: Development and Disease Mechanisms
Mechanisms that direct human development from conception to birth. Conserved molecular and cellular pathways regulate tissue and organ development; errors in these pathways result in congenital anomalies and human diseases. Topics: molecules regulating development, cell induction, developmental gene regulation, cell migration, programmed cell death, pattern formation, stem cells, cell lineage, and development of major organ systems. Emphasis on links between development and clinically significant topics including infertility, assisted reproductive technologies, contraception, prenatal diagnosis, multiparity, teratogenesis, inherited birth defects, fetal therapy, adolescence, cancer, and aging.
Terms: Aut
| Units: 4
DBIO 202: Assisted Reproductive Technologies (HUMBIO 150A, OBGYN 202)
Primary and current literature in basic and clinical science aspects of assisted reproductive technologies (ART), and demonstrations of current ART techniques including in vitro fertilization and embryo culture, and micromanipulation procedures such as intracytoplasmic sperm injection and embryo biopsy and cryopreservation.Class only may be taken for 1 unit. 2 units includes papers and attendance at clinical demonstrations. 3 units includes a term paper. Recommended:
DBIO 201, or consent of instructors.
Terms: Win
| Units: 1-3
Instructors:
Behr, B. (PI)
;
Porzig, E. (PI)
DBIO 203: Advanced Genetics (BIO 203, GENE 203)
For graduate students in Bioscience programs; may be appropriate for graduate students in other programs. Focused on application of the genetics toolbox to problems in modern biology research. Topics covered include analytic methods, genetic manipulation, genome analysis, and human genetics. Lectures and faculty-led discussion sections with evaluation of papers. Students with minimal experience in genetics should prepare by working out problems in college level textbooks.
Terms: Aut
| Units: 4
DBIO 215: Frontiers in Biological Research (BIOC 215, GENE 215)
Literature discussion in conjunction with the Frontiers in Biological Research seminar series in which investigators present current work. Students and faculty meet beforehand to discuss papers from the speaker¿s primary research literature. Students meet with the speaker after the seminar to discuss their research and future direction, commonly used techniques to study problems in biology, and comparison between the genetic and biochemical approaches in biological research.
Terms: Aut, Win
| Units: 1
| Repeatable
3 times
(up to 3 units total)
DBIO 220: Genomics and Personalized Medicine (GENE 210)
Principles of genetics underlying associations between genetic variants and disease susceptibility and drug response. Topics include: genetic and environmental risk factors for complex genetic disorders; design and interpretation of genome-wide association studies; pharmacogenetics; full genome sequencing for disease gene discovery; population structure and genetic ancestry; use of personal genetic information in clinical medicine; ethical, legal, and social issues with personal genetic testing. Hands-on workshop making use of personal or publicly available genetic data. Prerequisite:
GENE 202 or 203.
Terms: Spr
| Units: 3
DBIO 221: Current Issues in Aging (GENE 221)
Current research literature on genetic mechanisms of aging in animals and human beings. Topics include: mitochondria mutations, insulin-like signaling, sirtuins, aging in flies and worms, stem cells, human progeria, and centenarian studies. Prerequisite:
GENE 203.
Terms: Spr
| Units: 2
DBIO 257: The Biology of Stem Cells (HUMBIO 157)
The role of stem cells in human development and potential for treating disease. Guest lectures by biologists, ethicists, and legal scholars. Prerequisites: 2A,B, or consent of instructor.
Last offered: Spring 2011
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