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Combines biological knowledge and methods with quantitative engineering principles. Quantitative review of biochemistry and metabolism; recombinant DNA technology and synthetic biology (metabolic engineering). The production of protein pharaceuticals as a paradigm for the application of chemical engineering principles to advanced process development within the framework of current business and regulatory requirements. Prerequisite: CHEMENG 181 (formerly 188) or BIOSCI 41, or equivalent.

This course provides an overview of cutting-edge advances in biotechnology with a focus on therapeutic, health-related and agricultural topics. We will hear from academic and industrial speakers from a range of areas including novel anti-infectives, AI tools, quantitative microfluidics biotechnology research, new therapies for the treatment of addiction, neurodegenerative diseases like Alzheimer¿s disease, plant bioengineering, immuno-oncology, science journalism, and venture capital investing in biotechnology. This course is designed for students interested in pursuing a career in the biotech industry.

Introduction to microbial metabolic pathways and to the pathway logic with a special focus on microbial bioenergy systems. The first part of the course emphasizes the metabolic and biochemical principles of pathways, whereas the second part is more specifically directed toward using this knowledge to understand existing systems and to design innovative microbial bioenergy systems for biofuel, biorefinery, and environmental applications. There also is an emphasis on the implications of rerouting of energy and reducing equivalents for the fitness and ecology of the organism. Prerequisites: CHEMENG 174 or 181 and organic chemistry, or equivalents.

Fundamentals of the equilibrium properties and dynamic behaviors of polymers. Key concepts include single chain conformations, solution thermodynamics, scaling relations, polymer architecture, stress relaxation, and viscoelasticity. These concepts will be considered in the context of polymeric materials including but not limited to solutions and melts, networks (gels and rubbers), glasses, block copolymers, polyelectrolytes, and biopolymers. Prerequisites: Chem 33, Chemeng 110A or Chem 171, and Chemeng 105 or CME 102 and CME 104; or instructor approval.

Metabolism plays a central role in organismal homeostasis, orchestrating the biochemical processes that fuel our cells and sustain our bodies. This course provides overview of cellular metabolism and then dives into the essential role of metabolism in human health and disease, blending core concepts with the latest in research and technological advancements. Students will explore major metabolic processes and their role in diseases like diabetes, neurodegeneration, and cancer. Emphasizing the power of modern quantitative tools, from metabolomics to flux analysis, the course highlights cutting-edge methods in metabolic research. The course will feature guest speakers who are experts in these fields. A journal club component encourages critical engagement with seminal literature, fostering skills in analysis and scientific communication. Overall, students will gain insights into the complexities of the metabolism field and its potential as a target for therapeutic intervention while showcasing the role of technology in informing biological discoveries.

Laboratory and theoretical work leading to partial fulfillment of requirements for an advanced degree. Course may be repeated for credit.