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COMPMED 87Q: Laboratory Mouse in Biomedical Research

What is a nude mouse and why is it used in cancer research? Why do my mouse pups have a different coat color than their parents? What is a knockout mouse? Answers to these and more are in this introduction to the laboratory mouse, one of the most widely used models in biomedical research. We will explore the natural history and origin of the laboratory mouse; the ethics and regulations on the use of mice in research; the characteristics and nomenclature of commonly used mouse strains; the anatomy, physiology, and husbandry of mice; common mouse diseases and their effects on research; mouse coat color genetics and its relevance to human diseases; immunodeficient mouse models and their uses in research; and the technology for genetically engineering mice (e.g., transgenic mice). Hands-on laboratories will include mouse handling and biometeorology, necropsy and tissue sampling and anesthesia and surgery. Each student is expected to read research papers that use the mouse as a research model and give a presentation on a topic of their choice. Students interested in human or veterinary medicine and/or a career in biomedical research will benefit from this seminar. Class is limited to 12 students.
Last offered: Autumn 2022 | UG Reqs: GER: DB-NatSci, WAY-SMA

EARTHSYS 4: Coevolution of Earth and Life (EPS 4)

( EPS 4 - Former GEOLSCI 4) Earth is the only planet in the universe currently known to harbor life. When and how did Earth become inhabited? How have biological activities altered the planet? How have environmental changes affected the evolution of life? In this course, we explore these questions by developing an understanding of life's multi-billion year history using tools from biology, geology, paleontology, and chemistry. We discuss major groups of organisms, when they appear in the rock record, and how they have interacted with the Earth to create the habitats and ecosystems that we are familiar with today. Change of Department Name: Earth & Planetary Sciences (Formerly Geological Science)
Terms: Aut | Units: 4 | UG Reqs: GER: DB-NatSci, WAY-SMA

EARTHSYS 10: Introduction to Earth Systems

For non-majors and prospective Earth Systems majors. Multidisciplinary approach using the principles of geology, biology, engineering, and economics to describe how the Earth operates as an interconnected, integrated system. Goal is to understand global change on all time scales. Focus is on sciences, technological principles, and sociopolitical approaches applied to solid earth, oceans, water, energy, and food and population. Case studies: environmental degradation, loss of biodiversity, and resource sustainability.
Terms: Aut | Units: 4 | UG Reqs: GER: DB-NatSci, WAY-SMA

EARTHSYS 11: Introduction to Geology (EPS 1)

(Former GEOLSCI 1) Why are earthquakes, volcanoes, and natural resources located at specific spots on the Earth's surface? Why are there rolling hills to the west behind Stanford and soaring granite walls to the east in Yosemite? What was the Earth like in the past, and what will it be like in the future? Lectures, hands-on laboratories, in-class activities, and one virtual field trip will help you see the Earth through the eyes of a geologist. Topics include plate tectonics, the cycling and formation of different types of rocks, and how geologists use rocks to understand Earth's history. Change of Department Name: Earth & Planetary Sciences (Formerly Geological Science)
Terms: Spr | Units: 5 | UG Reqs: GER: DB-NatSci, WAY-SMA, WAY-AQR

EARTHSYS 38N: The Worst Journey in the World: The Science, Literature, and History of Polar Exploration (EPS 38N, ESS 38N)

(Formerly GEOLSCI 38N) This course examines the motivations and experiences of polar explorers under the harshest conditions on Earth, as well as the chronicles of their explorations and hardships, dating to the 1500s for the Arctic and the 1700s for the Antarctic. Materials include The Worst Journey in the World by Aspley Cherry-Garrard who in 1911 participated in a midwinter Antarctic sledging trip to recover emperor penguin eggs. Optional field trip into the high Sierra in March. Change of Department Name: Earth and Planetary Science (Formerly Geologic Sciences).
Terms: Aut | Units: 3 | UG Reqs: GER: DB-NatSci

EARTHSYS 104: The Water Course (EARTHSYS 204, GEOPHYS 104, GEOPHYS 204)

The Central Valley of California provides a third of the produce grown in the U.S., but recent droughts and increasing demand have raised concerns about both food and water security. The pathway that water takes from rainfall to the irrigation of fields or household taps ('the water course') determines the quantity and quality of the available water. Working with various data sources (measurements made on the ground, in wells, and from satellites) allows us to model the water budget in the valley and explore the recent impacts on freshwater supplies.
Last offered: Winter 2022 | UG Reqs: GER: DB-NatSci, WAY-AQR, WAY-SMA

EARTHSYS 110: Introduction to the Foundations of Contemporary Geophysics (GEOPHYS 110, GEOPHYS 215)

Introduction to the foundations of contemporary geophysics. Lectures link important topics in contemporary Geophysics ("What we study") to methods used to make progress on these topics ("How we study"). Topics range from plate tectonics to natural hazards; ice sheets to sustainability. For each topic, we focus is on how the interpretation of geophysical measurements (e.g., gravity, seismology, heat flow, electromagnetism and remote sensing) provides fundamental insight into the behavior of the Earth. The course will includes a required all-day Saturday field exercise Feb 02/10 (rain-date: 02/17). Prerequisite: CME 100 or MATH 51, or co-registration in either.
Terms: Win | Units: 3 | UG Reqs: GER: DB-NatSci, WAY-AQR, WAY-SMA

EARTHSYS 111: Biology and Global Change (BIO 117, EARTHSYS 217, ESS 111)

The biological causes and consequences of anthropogenic and natural changes in the atmosphere, oceans, and terrestrial and freshwater ecosystems. Topics: glacial cycles and marine circulation, greenhouse gases and climate change, tropical deforestation and species extinctions, and human population growth and resource use. Prerequisite: Biology or Human Biology core or BIO 81 or graduate standing.
Terms: Win | Units: 4 | UG Reqs: GER: DB-NatSci, WAY-SMA

EARTHSYS 141: Remote Sensing of the Oceans (EARTHSYS 241, ESS 141, ESS 241, GEOPHYS 141)

How to observe and interpret physical and biological changes in the oceans using satellite technologies. Topics: principles of satellite remote sensing, classes of satellite remote sensors, converting radiometric data into biological and physical quantities, sensor calibration and validation, interpreting large-scale oceanographic features.
Terms: Win | Units: 3-4 | UG Reqs: GER: DB-NatSci, WAY-AQR
Instructors: Arrigo, K. (PI)

EARTHSYS 144: Fundamentals of Geographic Information Science (GIS) (ESS 164)

Everything is somewhere, and that somewhere matters." The rapid growth and maturity of spatial data technologies over the past decade represent a paradigm shift in the applied use of location data from high-level overviews of administrative interests, to highly personalized location-based services that place the individual at the center of the map, at all times. The use of spatial data and related technology continues to grow in fields ranging from environmental sciences to epidemiology to market prediction. This course will present an overview of current approaches to the use of spatial data and its creation, capture, management, analysis and presentation, in a research context. Topics will include modeling of geographic objects and associated data, modeling of geographic space and the conceptual foundations of "spatial thinking," field data collection, basic spatial statistical analysis, remote sensing & the use of satellite-based imagery, "Big Data" and machine learning approaches t more »
Everything is somewhere, and that somewhere matters." The rapid growth and maturity of spatial data technologies over the past decade represent a paradigm shift in the applied use of location data from high-level overviews of administrative interests, to highly personalized location-based services that place the individual at the center of the map, at all times. The use of spatial data and related technology continues to grow in fields ranging from environmental sciences to epidemiology to market prediction. This course will present an overview of current approaches to the use of spatial data and its creation, capture, management, analysis and presentation, in a research context. Topics will include modeling of geographic objects and associated data, modeling of geographic space and the conceptual foundations of "spatial thinking," field data collection, basic spatial statistical analysis, remote sensing & the use of satellite-based imagery, "Big Data" and machine learning approaches to spatial data, and cartographic design and presentation including the use of web-based "Storymap" platforms. The course will consist of weekly lectures, guest speakers, computer lab assignments, midterm and final exams, as well as an individual final project requirement. This course must be taken for a minimum of 3 units and a letter grade to be eligible for Ways credit.
Terms: Aut, Spr | Units: 3-4 | UG Reqs: GER: DB-NatSci, WAY-AQR
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