printer friendly pageBIOC 210: Advanced Topics in Membrane Trafficking
The structure, function, and biosynthesis of cellular membranes and organelles. Current literature. Prerequisite: consent of instructor.
BIOC 220: Chemistry of Biological Processes (CSB 220)
The principles of organic and physical chemistry as applied to biomolecules. Goal is a working knowledge of chemical principles that underlie biological processes, and chemical tools used to study and manipulate biological systems. Prerequisites: organic chemistry and biochemistry, or consent of instructor.
BIOC 225: Interdisciplinary Approaches to Cell Biology: the Role of the Cytoskeleton
The molecular basis of energy transduction leading to movements generated by microfilament-based and microtubule-based motors. Forms of myosin, dynein, and kinesin and their roles in the cell as a model for understanding the structural, biochemical, and functional properties of biological machines. Topics: structure of the molecular motors and their accessory proteins; regulation of the function of motile assemblies; functions of molecular motors in cells; spatial and temporal controls on the formation of motile assemblies in cells. Experimental approaches: genetic analysis, DNA cloning and expression, reconstitution of functional assemblies from purified proteins, x-ray diffraction, three-dimensional reconstruction of electron microscope images, spectroscopic methods, high-resolution light microscopy, and computational approaches. Prerequisites: basic biochemistry and cell biology.
BIOC 228: Computational Genomic Biology (BIOMEDIN 228)
Application of computational genomics methods to biological problems. Topics include: assembly of genomic sequences; genome databases; comparative genomics; gene discovery; gene expression analyses including gene clustering by expression, transcription factor binding site discovery, metabolic pathway discovery, functional genomics, and gene and genome ontologies; and medical diagnostics using SNPs and gene expression. Recent papers from the literature and hands-on use of the methods. Prerequisites: introductory course in computational molecular biology or genomics such as
BIOC 218,
BIOMEDIN 214 or
GENE 211.
| Repeatable
for credit
BIOC 230: Molecular Interventions in Human Disease
For M.D. students who intend to declare a concentration in molecular basis of medicine, MSTP students, and Ph.D. students. Advanced medical biochemistry focusing on cases where molecular-level research has led to new medical treatments or changes in the understanding of important diseases. Different topics each week explore the underlying molecular basis of a variety of diseases and the reasons for success and failure in molecular approaches to treatment. Student-led discussions dissect papers from the primary medical and scientific research literature.
BIOC 278: Systems Biology (BIOE 310, CS 278, CSB 278)
Complex biological behaviors through the integration of computational modeling and molecular biology. Topics: reconstructing biological networks from high-throughput data and knowledge bases. Network properties. Computational modeling of network behaviors at the small and large scale. Using model predictions to guide an experimental program. Robustness, noise, and cellular variation. Prerequisites: background in biology and mathematical analysis.
BIOE 41: Physical Biology of Macromolecules
Principles of statistical physics and thermodynamics, with applications to molecular biology. Topics include entropy, temperature, free energy, chemical forces, self assembly, cooperative transitions in macromolecules, enzyme kinetics, molecular machines, and an introduction to genomic and proteomic technologies. Corequisite:
BIO 41.
Terms: Aut
| Units: 4
| UG Reqs: WAY-AQR, WAY-SMA
Instructors:
Quake, S. (PI)
BIOE 42: Physical Biology of Cells
Principles of transport, continuum mechanics, and fluids, with applications to cell biology. Topics include random walks, diffusion, Langevin dynamics, transport theory, low Reynolds number flow, and beam theory, with applications including quantitative models of protein trafficking in the cell, mechanics of the cell cytoskeleton, the effects of molecular noise in development, the electromagnetics of nerve impulses, and an introduction to cardiovascular fluid flow. Concurrent enrollment in
BIO 42 is required.
Terms: Win
| Units: 4
| UG Reqs: WAY-AQR, WAY-SMA
Instructors:
Huang, K. (PI)
BIOE 44: Synthetic Biology Lab
Introduction to next-generation techniques in genetic, molecular, biochemical, and cellular engineering. Lab modules build upon current research including: gene and genome engineering via decoupled design and construction of genetic material; component engineering focusing on molecular design and quantitative analysis of experiments; device and system engineering using abstracted genetically encoded objects; and product development based on useful applications of biological technologies. Limited enrollment. Priority given to majors.
Terms: Spr
| Units: 4
| UG Reqs: WAY-SMA
Instructors:
Endy, D. (PI)
BIOE 70Q: Medical Device Innovation
Preference to sophomores. Commonly used medical devices in different medical specialties. Guest lecturers include Stanford Medical School physicians, entrepreneurs, and venture capitalists. How to identify clinical needs and design device solutions to address these needs. Fundamentals of starting a company. Field trips to local medical device companies; workshops. No previous engineering training required.
Terms: Spr
| Units: 3
| UG Reqs: WAY-CE
Instructors:
Mandato, J. (PI)
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