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Genetic analysis of the key regulatory circuits governing the control of cell division. Illustration of key principles that can be generalized to other synthetic and natural biological circuits. Focus on tractable model organisms; growth control; irreversible biochemical switches; chromosome duplication; mitosis; DNA damage checkpoints; MAPK pathway-cell cycle interface; oncogenesis. Analysis of classic and current primary literature. Satisfies Central Menu Area 2.

Genetic analysis of the key regulatory circuits governing the control of cell division. Illustration of key principles that can be generalized to other synthetic and natural biological circuits. Focus on tractable model organisms; growth control; irreversible biochemical switches; chromosome duplication; mitosis; DNA damage checkpoints; MAPK pathway-cell cycle interface; oncogenesis. Analysis of classic and current primary literature. Satisfies Central Menu Area 2.

The variability of the human genome and the role of genomic information in research, drug discovery, and human health. Concepts and interpretations of genomic markers in medical research and real life applications. Human genomes in diverse populations. Original contributions from thought leaders in academia and industry and interaction between students and guest lecturers. Students with a major, minor or coterm in Biology: 109A/209A or 109B/209B may count toward degree program but not both.

Continuation of 109A/209A. Genetic drift: the path of human predecessors out of Africa to Europe and then either through Asia to Australia or through northern Russia to Alaska down to the W. Coast of the Americas. Support for this idea through the histocompatibility genes and genetic sequences that predispose people to diseases. Guest lectures from academia and pharmaceutical companies. Prerequisite: Biology or Human Biology core. Students with a major, minor or coterm in Biology: 109A/209A or 109B/209B may count toward degree program but not both.

Preference to sophomores. Knowledge gained from sequencing human genomes and implications for medicine and biomedical research. Novel diagnoses and treatment of diseases, including stem cells, gene therapy and rational drug design. Personal genomics and how it is used to improve health and well being. Social and ethical implications of genetic information such as privacy, discrimination and insurability. Course Webpage: http://biochem118.stanford.edu/.

Molecular basis of inherited human disease. Diagnostics approaches: simple Mendelian diseases and complex, multifactorial diseases. Genomics: functional genomics, epigenetics, gene expression, SNPs, copy number and other structural genomic variations involved in disease. Novel therapeutic methods: stem cell therapy, gene therapy and drug developments that depend on the knowledge of genomics. Personal genomics, pharmacogenomics, clinical genomics and their role in the future of preventive medicine. Prerequisites: BIO 41 or HUMBIO 2A or consent of instructor. Those with credit in BIOC 118 not eligible to enroll. Course webpage: http://biochem158.stanford.edu/

Overview of the most pressing biosecurity issues facing the world today. Guest lecturers have included former Secretary of State Condoleezza Rice, former Special Assistant on BioSecurity to Presidents Clinton and Bush Jr. Dr. Ken Bernard, Chief Medical Officer of the Homeland Security Department Dr. Alex Garza, eminent scientists, innovators and physicians in the field, and leaders of relevant technology companies. How well the US and global healthcare systems are prepared to withstand a pandemic or a bioterrorism attack, how the medical/healthcare field, government, and the technology sectors are involved in biosecurity and pandemic or bioterrorism response and how they interface, the rise of synthetic biology with its promises and threats, global bio-surveillance, making the medical diagnosis, isolation, containment, hospital surge capacity, stockpiling and distribution of countermeasures, food and agriculture biosecurity, new promising technologies for detection of bio-threats and countermeasures. Open to medical, graduate, and undergraduate students. No prior background in biology necessary. This course satisfies the TiS requirement for Engineering students; please check with your major advisor to verify this. 4 units for twice weekly attendance (Mon. and Wed.); additional 1 unit for writing a research paper for 5 units total maximum. PLEASE NOTE: This class will meet for the first time on Wednesday, April 1.

Introduction to biology in a marine context. Principles of plant biology: physiology, structure, diversity. Principles of evolution: macro and microevolution, population genetics. Ecology: the principles governing the distribution and abundance of organisms; population, community, and ecosystem ecology. Equivalent to BIO 43. Corequisite: BIOHOPK 44Y.

Laboratory and field projects provide working familiarity with the concepts, organisms, and techniques of plant and evolutionary biology, and ecology. Emphasis is on hands-on experimentation in the marine environment, analysis of data, and written and oral presentation of the experiments. Equivalent to BIO 44Y. Corequisite: BIOHOPK 43. Satisfies WIM in Biology.