printer friendly pageBIO 244: Fundamentals of Molecular Evolution (BIO 113)
The inference of key molecular evolutionary processes from DNA and protein sequences. Topics include random genetic drift, coalescent models, effects and tests of natural selection, combined effects of linkage and natural selection, codon bias and genome evolution. Prerequisites: Biology core or graduate standing in any department, and consent of instructor.
Terms: Spr
| Units: 4
Instructors:
Petrov, D. (PI)
BIO 249: The Neurobiology of Sleep (BIO 149, HUMBIO 161)
(Graduate students register for 249.) Preference to seniors and graduate students. The neurochemistry and neurophysiology of changes in brain activity and conscious awareness associated with changes in the sleep/wake state. Behavioral and neurobiological phenomena including sleep regulation, sleep homeostasis, circadian rhythms, sleep disorders, sleep function, and the molecular biology of sleep. Enrollment limited to 16.
Last offered: Winter 2009
BIO 250: Human Behavioral Biology (BIO 150, HUMBIO 160)
Multidisciplinary. How to approach complex normal and abnormal behaviors through biology. How to integrate disciplines including sociobiology, ethology, neuroscience, and endocrinology to examine behaviors such as aggression, sexual behavior, language use, and mental illness.
Terms: Spr
| Units: 5
Instructors:
Sapolsky, R. (PI)
BIO 254: Molecular and Cellular Neurobiology (BIO 154, NBIO 254)
For advanced undergraduates and graduate students. Cellular and molecular mechanisms in the organization and functions of the nervous system. Topics: wiring of the neuronal circuit, synapse structure and synaptic transmission, signal transduction in the nervous system, sensory systems, molecular basis of behavior including learning and memory, molecular pathogenesis of neurological diseases. Prerequisite for undergraduates: Biology core or equivalent, or consent of instructors.
BIO 256: Epigenetics (BIO 156, GENE 206, PATH 206)
For graduate students in the Biosciences and upper level Biology undergraduates. Mechanisms by which phenotypes not determined by the DNA sequence are stably inherited in successive cell divisions. From the discovery of position-effect variegation in Drosophila in the 1920s to present-day studies of covalent modifications of histones and DNA methylation. Topics include: position effect, gene silencing, heterochromatin, centromere identity, genomic imprinting, histone code, variant histones, and the role of epigenetics in cancer. Prerequisite: BIO41 and
BIO42 , or
GENE 203, or consent of instructor.
Terms: Spr
| Units: 2
Instructors:
Gozani, O. (PI)
;
Lipsick, J. (PI)
BIO 263: Neural Systems and Behavior (BIO 163, HUMBIO 163)
The field of neuroethology and its vertebrate and invertebrate model systems. Research-oriented. Readings include reviews and original papers. How animal brains compare; how neural circuits are adapted to species-typical behavior; and how the sensory worlds of different species represent the world. Lectures and required discussions. Prerequisites:
BIO 42,
HUMBIO 4A.
Terms: Aut
| Units: 4
Instructors:
Fernald, R. (PI)
BIO 265: Cellular and Molecular Therapeutic Approaches to Neurological Disorders (BIO 165)
Current therapeutic research for neurological conditions, including stroke, epilepsy, neurodegenerative disorders, depression, anxiety, and aging. Sources include primary literature. Guest lecturers.
Terms: Win
| Units: 1
Instructors:
House, P. (PI)
;
Sorrells, S. (PI)
BIO 267: Molecular Mechanisms of Neurodegenerative Disease (NENS 267)
The epidemic of neurodegenerative disorders such as Alzheimer's and Parkinson's disease occasioned by an aging human population. Genetic, molecular, and cellular mechanisms. Clinical aspects through case presentations.
Terms: Win
| Units: 4
BIO 271: Principles of Cell Cycle Control (BIO 171, CSB 271)
Genetic analysis of the key regulatory circuits governing the control of cell division. Illustration of key principles that can be generalized to other synthetic and natural biological circuits. Focus on tractable model organisms; growth control; irreversible biochemical switches; chromosome duplication; mitosis; DNA damage checkpoints; MAPK pathway-cell cycle interface; oncogenesis. Analysis of classic and current primary literature.
Terms: Aut
| Units: 3
Instructors:
Ferrell, J. (PI)
;
Skotheim, J. (PI)
BIO 274S: Hopkins Microbiology Course (BIOHOPK 274, CEE 274S, EESS 253S)
(Formerly
GES 274S.) Four-week, intensive. The interplay between molecular, physiological, ecological, evolutionary, and geochemical processes that constitute, cause, and maintain microbial diversity. How to isolate key microorganisms driving marine biological and geochemical diversity, interpret culture-independent molecular characterization of microbial species, and predict causes and consequences. Laboratory component: what constitutes physiological and metabolic microbial diversity; how evolutionary and ecological processes diversify individual cells into physiologically heterogeneous populations; and the principles of interactions between individuals, their population, and other biological entities in a dynamically changing microbial ecosystem. Prerequisites:
CEE 274A,B, or equivalents.
Terms: Sum
| Units: 9-12
| Repeatable
for credit
Instructors:
Francis, C. (PI)
;
Spormann, A. (PI)
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