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BIO 113: Fundamentals of Molecular Evolution (BIO 244)

The inference of key molecular evolutionary processes from DNA and protein sequences. Topics include random genetic drift, coalescent models, effects and tests of natural selection, combined effects of linkage and natural selection, codon bias and genome evolution. Prerequisites: Biology core or graduate standing in any department, and consent of instructor.
Terms: Spr | Units: 4 | UG Reqs: GER: DB-NatSci

BIO 117: Biology and Global Change (EARTHSYS 111)

The biological causes and consequences of anthropogenic and natural changes in the atmosphere, oceans, and terrestrial and freshwater ecosystems. Topics: glacial cycles and marine circulation, greenhouse gases and climate change, tropical deforestation and species extinctions, and human population growth and resource use. Prerequisite: Biology or Human Biology core or graduate standing.
Terms: Win | Units: 4 | UG Reqs: GER: DB-NatSci, WAY-SMA

BIO 118: Genetic Analysis of Biological Processes (BIO 218)

Genetic principles and their experimental applications. Emphasis is on the identification and use of mutations to study cellular function. Prerequisite: Biology core.
Terms: Spr | Units: 5 | UG Reqs: WAY-SMA, GER: DB-NatSci

BIO 121: Biogeography

Global distributions of organisms through the Phanerozoic, with emphasis on historical causes. Topics: plate tectonics, island biogeography, climatic change, dispersal, vicariance, ecology of invasions, extinction, gradients, diversity.
Last offered: Spring 2009 | UG Reqs: GER: DB-NatSci, WAY-SMA

BIO 122: Along the Track of the Yellowstone Hotspot: Fusion of Art and Science (ARTSTUDI 184A)

The 20-million-year-old track of the Yellowstone hotspot through western North America, using the field setting to investigate ecology, evolution, and geology through an aesthetic and documentary media lens. Students create: experiential ways to learn about the natural world; a scientific yet personal intimacy about how ecosystems work and how they change; and ways to convey their observations to the public. Required trip to Yellowstone National Park.
Terms: Spr | Units: 4

BIO 125: Ecosystems of California

The diversity and functioning of California ecosystems through time and how human beings have impacted and managed them. Prerequisite: 43, HUMBIO 2A, or EARTHSYS 10.
Terms: Spr | Units: 3 | UG Reqs: GER: DB-NatSci
Instructors: Mooney, H. (PI)

BIO 129A: Cellular Dynamics I: Cell Motility and Adhesion

Cell motility emphasizing role of actin assembly and dynamics coupling actin organization to cell movement. Interaction of cells with extracellular matrix, and remodelling of extracellular matrix in development and disease. Directed cell migration by chemotaxis (neuronal path-finding, immune cells). Cell-cell adhesion, formation of intercellular junctions and mechanisms regulating cell-cell interactions in development and diseases. Emphasis is on experimental logic, methods, problem solving, and interpretation of results. Students present research papers. Prerequisite: Biology core.
Terms: Win | Units: 4 | UG Reqs: GER: DB-NatSci, WAY-AQR, WAY-SMA

BIO 129B: Cellular Dynamics II: Building a Cell

Principles of cell organization; how common biochemical pathways are modified to generate diversity in cell structure and function. Roles of actin and microtubule cytoskeletons in cellular architecture. Mechanisms of protein sorting and trafficking, and protein modules and switches in regulating cell polarity. Yeast to polarized epithelial cells and neurons. Emphasis is on experimental logic, methods, problem solving, and interpretation of results. Students present research papers. Prerequisite: Biology core. Recommended: 129A.
Terms: Spr | Units: 4 | UG Reqs: GER: DB-NatSci

BIO 132: Advanced Imaging Lab in Biophysics (APPPHYS 232, BIO 232, BIOPHYS 232, MCP 232)

Laboratory and lectures. Advanced microscopy and imaging, emphasizing hands-on experience with state-of-the-art techniques. Students construct and operate working apparatus. Topics include microscope optics, Koehler illumination, contrast-generating mechanisms (bright/dark field, fluorescence, phase contrast, differential interference contrast), and resolution limits. Laboratory topics vary by year, but include single-molecule fluorescence, fluorescence resonance energy transfer, confocal microscopy, two-photon microscopy, and optical trapping. Limited enrollment. Recommended: basic physics, Biology core or equivalent, and consent of instructor.
Terms: Spr | Units: 4 | UG Reqs: GER: DB-NatSci

BIO 137: Plant Genetics (BIO 237)

Gene analysis, mutagenesis, transposable elements; developmental genetics of flowering and embryo development; biochemical genetics of plant metabolism; scientific and societal lessons from transgenic plants. Prerequisite: Biology core or consent of instructor.
Terms: Spr | Units: 3-4 | UG Reqs: WAY-SMA, GER: DB-NatSci
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