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BIOE 261: Principles and Practice of Stem Cell Engineering (NSUR 261)

Quantitative models used to characterize incorporation of new cells into existing tissues emphasizing pluripotent cells such as embryonic and neural stem cells. Molecular methods to control stem cell decisions to self-renew, differentiate, die, or become quiescent. Practical, industrial, and ethical aspects of stem cell technology application. Final projects: team-reviewed grants and business proposals.

BIOE 280: Skeletal Development and Evolution (ME 280)

The mechanobiology of skeletal growth, adaptation, regeneration, and aging is considered from developmental and evolutionary perspectives. Emphasis is on the interactions between mechanical and chemical factors in the regulation of connective tissue biology. Prerequisites: BIO 42, and ME 80 or BIOE 42.
Terms: Spr | Units: 3
Instructors: Carter, D. (PI)

BIOE 281: Biomechanics of Movement (ME 281)

Experimental techniques to study human and animal movement including motion capture systems, EMG, force plates, medical imaging, and animation. The mechanical properties of muscle and tendon, and quantitative analysis of musculoskeletal geometry. Projects and demonstrations emphasize applications of mechanics in sports, orthopedics, and rehabilitation.
Terms: Win | Units: 3
Instructors: Delp, S. (PI)

BIOE 282: Performance, Development, and Adaptation of Skeletal Muscle

Fundamentals of skeletal muscle by study of classical and recent research articles. Emphasis on the interactions between mechanics, biology, and electrophysiology in skeletal muscle performance, development, adaptation, control, and disease. Lab activities explore research methods discussed in class. Limited Enrollment. Prerequisites: engineering or biology core coursework.
Terms: Aut | Units: 3
Instructors: Delp, S. (PI)

BIOE 284A: Cardiovascular Bioengineering (ME 284A)

Bioengineering principles applied to the cardiovascular system. Anatomy of human cardiovascular system, comparative anatomy, and allometric scaling principles. Cardiovascular molecular and cell biology. Overview of continuum mechanics. Form and function of blood, blood vessels, and the heart from an engineering perspective. Normal, diseased, and engineered replacement tissues.
Terms: Aut | Units: 3
Instructors: Taylor, C. (PI)

BIOE 284B: Cardiovascular Bioengineering

Continuation of ME 284A. Integrative cardiovascular physiology, blood fluid mechanics, and transport in the microcirculation. Sensing, feedback, and control of the circulation. Overview of congenital and adult cardiovascular disease, diagnostic methods, and treatment strategies. Engineering principles to evaluate the performance of cardiovascular devices and the efficacy of treatment strategies.
Terms: Win | Units: 3
Instructors: Taylor, C. (PI)

BIOE 291: Principles and Practice of Optogenetics for Optical Control of Biological Tissues

Principles and practice of optical control of biological processes (optogenetics), emphasizing bioengineering approaches. Theoretical, historical, and current practice of the field. Requisite molecular-genetic, optoelectronic, behavioral, clinical, and ethical concepts, and mentored analysis and presentation of relevant papers. Final projects of research proposals and a laboratory component in BioX to provide hands-on training. Contact instructor before registering.
Terms: Aut | Units: 3

BIOE 300A: Molecular and Cellular Bioengineering

The molecular and cellular bases of life from an engineering perspective. Analysis and engineering of biomolecular structure and dynamics, enzyme function, molecular interactions, metabolic pathways, signal transduction, and cellular mechanics. Quantitative primary literature. Prerequisites: CHEM 171 and BIO 41 or equivalents; MATLAB or an equivalent programming language.
Terms: Aut | Units: 3
Instructors: Bryant, Z. (PI)

BIOE 300B: Physiology and Tissue Engineering

The interaction, communication, and disorders of major organ systems and relevant developmental biology and tissue engineering from cells to complex organs.
Terms: Win | Units: 3

BIOE 301A: Molecular and Cellular Engineering Lab

Preference to Bioengineering graduate students. Practical applications of biotechnology and molecular bioengineering including recombinant DNA techniques, molecular cloning, microbial cell growth and manipulation, library screening, and microarrays. Emphasis is on experimental design and data analysis. Limited enrollment. Corequisite: 300A.
Terms: Aut, Win | Units: 2
Instructors: Cochran, J. (PI)
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