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GENE 218: Computational Analysis of Biological Information: Introduction to Python for Biologists (MI 218, PATH 218)

Computational tools for processing, interpretation, communication, and archiving of biological information. Emphasis is on sequence and digital microscopy/image analysis. Intended for biological and clinical trainees without substantial programming experience.
Terms: Sum | Units: 2 | Grading: Medical Option (Med-Ltr-CR/NC)
Instructors: ; Fire, A. (PI)

GENE 224: Principles of Pharmacogenomics (BIOMEDIN 224)

This course is an introduction to pharmacogenomics, including the relevant pharmacology, genomics, experimental methods (sequencing, expression, genotyping), data analysis methods and bioinformatics. The course reviews key gene classes (e.g., cytochromes, transporters) and key drugs (e.g., warfarin, clopidogrel, statins, cancer drugs) in the field. Resources for pharmacogenomics (e.g., PharmGKB, Drugbank, NCBI resources) are reviewed, as well as issues implementing pharmacogenomics testing in the clinical setting. Reading of key papers, including student presentations of this work; problem sets; final project selected with approval of instructor. Prerequisites: two of BIO 41, 42, 43, 44X, 44Y or consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 3 | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 276: Genetic Counseling Clinical Rotations

For genetic counseling students only. Supervised clinical experiences. May be repeated for credit. Prerequisite: GENE 275.
Terms: Aut, Win, Spr, Sum | Units: 1-7 | Repeatable for credit | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 278: Prenatal Genetic Counseling (CHPR 278)

Internet-based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their initial prenatal genetics rotation. Topics include prenatal genetic screening and diagnosis in the first and second trimesters, ultrasound, teratology, and genetic carrier screening.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Campion, M. (PI)

GENE 279: Pediatric and Adult Genetic Counseling (CHPR 279)

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their initial general genetics rotation. Topics include: common genetic conditions, assessment of child development and medical history in the context of a genetic workup, the pediatric genetics medical examination, dysmorphology, introduction to laboratory genetic testing, development of a differential diagnosis, and resources for case management and family support.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Hanson-Kahn, A. (PI)

GENE 280: Metabolic Genetic Counseling (CHPR 280)

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows genetic counseling students should take this course in conjunction with their metabolic genetics rotation. Topics include: overview of metabolic diseases; common pathways; diagnosis, management, and treatment of metabolic disorders; and newborn screening.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Hanson-Kahn, A. (PI)

GENE 281: Cancer Genetic Counseling (CHPR 281)

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their initial cancer genetics rotation. Topics include: cancer biology and cytogenetics; diagnosis and management of common cancer genetic syndromes¿ predictive testing; psychology of cancer genetic counseling; and topics recommended by ASCO guidelines.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Ormond, K. (PI)

GENE 283: Genetic Counseling Research

Genetic counseling students conduct clinical research projects as required by the department for graduation. May be repeated for credit. Pre- or corequisite: GENE 282.
Terms: Aut, Win, Spr, Sum | Units: 1-8 | Repeatable for credit | Grading: Medical Option (Med-Ltr-CR/NC)

GENE 287: CARDIOVASCULAR GENETICS (CHPR 287)

Internet-based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellow; genetic counseling students should take this course in conjunction with their cardiovascular genetics rotation. Topics include: Basic cardiology principles, including relevant anatomy and physiology; diagnosis, management and genetic testing as it relates to common inherited cardiovascular conditions in both the pediatric and adult setting; predictive genetic testing issues specific to inherited cardiovascular conditions; psychologic issues related to sudden death conditions. This course is designed for genetic counseling students, medical students, residents, post-doctoral fellows and nurses interested in inherited cardiovascular conditions.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Campion, M. (PI)

GENE 288: Neurogenetics

The Neurogenetics Course is a flipped classroom, just-in-time, modular design which will be available online for genetic counseling students, medical students, residents and fellows with an interest in inherited neurologic conditions. It will encompass an introductory to neurology for beginners, including an overview of neurologic exam and localization, to provide non-neurologist trainees a foundation for understanding the differential diagnosis process in neurology. The course will cover common and exemplary neurogenetics disorders spanning the adult and pediatric neurologic sub-specialties, with a core set of lectures for all learners to watch and a set of optional lectures for a minimum of 10 content hours. Talks will exemplify key genetic concepts such as triple repeat disorders and FSHD. It will also cover ethical and psychological topics as well as gene-targets therapeutics. This course will prepare students so classroom and clinical experiences can begin at a more advanced level and integrate concepts from the online course.nMedical students and graduate students outside of genetic counseling should obtain permission from instructor prior to enrollment. No prerequisite for genetic counseling students, genetics or neurology residents/fellows or post-docs.
Terms: Aut, Win, Spr, Sum | Units: 1 | Grading: Medical Satisfactory/No Credit
Instructors: ; Ormond, K. (PI)
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