Results for GENE

Preference to sophomores. Focus is on human genetics; also assisted reproduction and neuroscience. Topics include forensic use of DNA, genetic testing, genetic discrimination, eugenics, cloning, pre-implantation genetic diagnosis, neuroscientific methods of lie detection, and genetic or neuroscience enhancement. Student presentations on research paper conclusions.

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

Open to first year Department of Genetics and Developmental Biology students, to others with consent of instructors. Introduction to basic manipulations, both experimental and conceptual, in genetics and developmental biology.

Utilizes lectures and small group activities to develop a working knowlege of human genetics as applicable to clinical medicine. Basic principles of inheritance, risk assessment, and population genetics are illustrated using examples drawn from diverse areas of medical genetics practice including prenatal, pediatric, adult and cancer genetics. Practical aspects of molecular and cytogenetic diagnostic methods are emphasized. Existing and emerging treatment strategies for single gene disorders are also covered. Prerequisites: basic genetics. Only available to MD and MOM students.

BIOMEDIN 214: Representations and Algorithms for Computational Molecular Biology (BIOE 214, CS 274, GENE 214)Topics: This is a graduate level introduction to bioinformatics and computational biology, algorithms for alignment of biological sequences and structures, BLAST, phylogenetic tree construction, hidden Markov models, basic structural computations on proteins, protein structure prediction, molecular dynamics and energy minimization, statistical analysis of 3D structure, knowledge controlled terminologies for molecular function, expression analysis, chemoinformatics, pharmacogenetics, network biology. Lectures are supplemented with assignments and programming projects, which allow students to implement important computational biology algorithms. Firm prerequisite: CS 106B. NOTE: For students in the Department of Biomedical Data Science Program, this core course MUST be taken as a letter grade only.

Students analyze cutting edge science, develop a logical framework for evaluating evidence and models, and enhance their ability to design original research through exposure to experimental tools and strategies. The class runs in parallel with the Frontiers in Biological Research seminar series. Students and faculty meet on the Tuesday preceding each seminar to discuss a landmark paper in the speaker's field of research. Following the Wednesday seminar, students meet briefly with the speaker for a free-range discussion which can include insights into the speakers' paths into science and how they pick scientific problems.

Current Issues in Genetics is an in-house seminar series that meets each Academic Quarter for one hour per week (Friday, 4:00-5:00) and features talks by Genetics Department faculty, students, and postdoctoral fellows (with occasional visiting speakers). Thus, over the year, it provides a comprehensive overview of the work going on in the Department. First-year Ph.D. students in Genetics are required to enroll during all four Quarters, and students from other programs may be permitted to enroll with prior permission of the instructors.

This course is an introduction to pharmacogenomics, including the relevant pharmacology, genomics, experimental methods (sequencing, expression, genotyping), data analysis methods and bioinformatics. The course reviews key gene classes (e.g., cytochromes, transporters) and key drugs (e.g., warfarin, clopidogrel, statins, cancer drugs) in the field. Resources for pharmacogenomics (e.g., PharmGKB, Drugbank, NCBI resources) are reviewed, as well as issues implementing pharmacogenomics testing in the clinical setting. Reading of key papers, including student presentations of this work; problem sets; final project selected with approval of instructor. Prerequisites: two of BIO 41, 42, 43, 44X, 44Y or consent of instructor.

How are healthcare startups financed? Venture funds invest in risky companies but how do they themselves get funded, and how do they evaluate companies? How do company founders prepare for capital raising? How does intellectual property play? We explain both from the investor and founder viewpoints to analyze how to a) start a venture capital fund; b) present a healthcare company to a venture fund. We discuss financial frameworks specifically for the healthcare sector and how it differs to other segments. Additionally, guest lectures from venture capitalists, angel investors, and company founders will explain their respective perspectives.

Genetics graduate student lab research from first quarter to filing of candidacy. Prerequisite: consent of instructor.

For genetic counseling students, graduate students in genetics, medical students, residents, and postdoctoral fellows. Students will learn clinical applications of molecular genetics and genomics through lectures, problem sets, discussions and exams. Topics include gene structure and function, clinical consequences of genetic variation, structure and interrogation of the human genome, variant classification, approaches to the study of complex genetic disease, and emerging technologies such as gene therapy, stem cell biology and pharmacogenetics. Undergraduates require consent of instructor and a basic genetics course. Non-GC students: Please contact the instructor when you enroll.

For genetic counseling students, graduate students in human genetics, medical students, residents, and fellows; undergraduates with consent of instructor. Principles of medical genetics practice, including taking a family history, modes of inheritance and risk assessment, and mathematical principles of medical genetics (Bayes theorem, population genetics). An additional problem set is required for 3 units.

For genetic counseling students, medical students, residents, and fellows. Students will learn principles of cytogenetic, molecular genetic and biochemical genetic testing approaches and techniques through lectures, discussions and practical, case-based assignments. Topics include utility of assays for diagnosing genetic conditions, role of clinical assessment in test selection, critical assessment of medical literature to interpret lab results and clinical features of genetic conditions commonly diagnosed through genetic testing. Non-GC students: Please contact the instructor when you enroll.

For genetic counseling students only. Students will develop skills around communicating basic genetic information to patients, giving and receiving feedback and self-reflection through weekly role plays. Students will perform clinical observations in several clinical settings.

For genetic counseling students only. Supervised clinical experiences. May be repeated for credit.

Online course for genetic counseling students, graduate students in genetics, medical students, residents, fellows, and nurses interested in prenatal genetics. Genetic counseling students should take this course in conjunction with their initial prenatal genetics rotation. Topics include: prenatal screening and diagnostic testing, ultrasound, genetic carrier screening, teratology, fetal treatment and intervention, perinatal loss, termination, and infertility. Non-GC students: Please contact the instructor when you enroll.

Online course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their general genetics rotation. Topics include: clinical reasoning in medical genetics, techniques to prepare for the medical genetics visit, assessment of child development and medical history in the context of a genetic workup, dysmorphology, development of a differential diagnosis, and resources for case management and family support. Non-GC students: Please contact the instructor when you enroll.

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Genetic counseling students should take this course in conjunction with their metabolic genetics rotation. Topics include: overview of metabolic diseases; common pathways; diagnosis, management, and treatment of metabolic disorders; and newborn screening. Non-GC students: Please contact the instructor when you enroll.

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their initial cancer genetics rotation. Topics include: cancer biology and cytogenetics; diagnosis and management of common cancer genetic syndromes; predictive testing; psychology of cancer genetic counseling; and topics recommended by ASCO guidelines.Non-GC students: Please contact the instructor when you enroll.

Genetic counseling students conduct clinical research projects as required by the department for graduation. May be repeated for credit. Pre- or corequisite: GENE 282.

Presentation of clinical and research topics in human genetics, followed by case presentations from the medical genetics and biochemical genetics services. Course may be completed online or in-person. Non-GC students: Please contact the instructor when you enroll.

Year-long seminar primarily for 1st-year genetic counseling students. Fall: An introduction to genetic counseling history, principles, techniques, and professional development. Students will learn about the primary tenets of providing inclusive genetic counseling services and the various components that comprise a genetic counseling session.

For genetic counseling students only. This course aims to develop students' advanced counseling skills through formal analysis and discussion of their clinical experiences and integration of counseling theories. In addition, students will learn about relevant professional issues through a combination of presentations and activities. Must be taken for 3 quarters.

Online course for genetic counseling students, graduate students in genetics, medical students, residents, fellows, and nurses interested in inherited cardiovascular conditions. Genetic counseling students should take this course in conjunction with their cardiovascular genetics rotation. Topics include: Basic cardiology principles, including relevant anatomy and physiology; diagnosis, management and genetic testing as it relates to common inherited cardiovascular conditions in both the pediatric and adult setting; predictive genetic testing issues specific to inherited cardiovascular conditions; psychological issues related to sudden death conditions. Non-GC students: Please contact the instructor when you enroll.

Online, self-paced course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Topics include: Basic neurology principles, including relevant anatomy and physiology; diagnosis, management and genetic testing as it relates to common inherited neurological conditions in both the pediatric and adult setting; predictive genetic testing issues specific to inherited neurogenetic conditions. Non-GC students: Please contact the instructor when you enroll.

Online, self-paced course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Topics include a review of mechanisms of pathogenicity, phenotype assessment, and technical aspects of variant filtering and prioritization, and gene curation. Attendees will become familiar with the types of evidence to support or refute pathogenicity and the standards in doing so, and will develop skills to critically assess literature and existing databases for variant classification. Non-GC students: Please contact the instructor when you enroll.

Prerequisite: consent of instructor.

Enrollment limited to PhD students associated with departmental research groups in genetics or molecular biology.

Investigations sponsored by individual faculty members. Prerequisite: consent of instructor.