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GENE 207: Microfluidic Device Laboratory (BIOE 301D)

BIOE 301D is a hands-on laboratory class designed to teach students the basics of microfluidic device design, fabrication, operation, and troubleshooting. During the first week of class, life science and clinical labs across campus will come and pitch ideas for devices that would advance their own research. Students will then choose projects, form teams, and attempt to create devices to meet these needs via two design/build/test iterations. In the process, students will learn how to design efficient experiments, navigate uncertainty, and communicate with end users and consider their needs. BIOE 301D is an intensive 3-4 unit course that requires significant student effort and enrollment is limited to 15 students due to space constraints within the Microfluidics Foundry. To prioritize students likely to get the most out of the course, we will ask students to fill out a course application form prior to the start of spring quarter; priority will be given to students that need this course as a requirement to graduate
Terms: Spr | Units: 3-4

GENE 212: Introduction to Biomedical Data Science Research Methodology (BIOE 212, BIOMEDIN 212, CS 272)

Capstone Biomedical Data Science experience. Hands-on software building. Student teams conceive, design, specify, implement, evaluate, and report on a software project in the domain of biomedicine. Creating written proposals, peer review, providing status reports, and preparing final reports. Issues related to research reproducibility. Guest lectures from professional biomedical informatics systems builders on issues related to the process of project management. Software engineering basics. Because the team projects start in the first week of class, attendance that week is strongly recommended. Prerequisites: BIOMEDIN 210 or 214 or 215 or 217 or 260. Preference to BMI graduate students. Consent of instructor required.NOTE: For students in the Department of Biomedical Data Science Program, this core course MUST be taken as a letter grade only.
Terms: Spr | Units: 3-5

GENE 215: Frontiers in Biological Research (BIOC 215, DBIO 215)

Students analyze cutting edge science, develop a logical framework for evaluating evidence and models, and enhance their ability to design original research through exposure to experimental tools and strategies. The class runs in parallel with the Frontiers in Biological Research seminar series. Students and faculty meet on the Tuesday preceding each seminar to discuss a landmark paper in the speaker's field of research. Following the Wednesday seminar, students meet briefly with the speaker for a free-range discussion which can include insights into the speakers' paths into science and how they pick scientific problems.
Terms: Aut, Win, Spr | Units: 1 | Repeatable 3 times (up to 3 units total)

GENE 218: Computational Analysis of Biological Information: Introduction to Python for Biologists (MI 218, PATH 218)

Computational tools for processing, interpretation, communication, and archiving of biological information. Emphasis is on sequence and digital microscopy/image analysis. Intended for biological and clinical trainees without substantial programming experience.
Terms: Spr | Units: 3

GENE 219: Current Issues in Genetics

Current Issues in Genetics is an in-house seminar series that meets each Academic Quarter for one hour per week (Friday, 4:00-5:00) and features talks by Genetics Department faculty, students, and postdoctoral fellows (with occasional visiting speakers). Thus, over the year, it provides a comprehensive overview of the work going on in the Department. First-year Ph.D. students in Genetics are required to enroll during all four Quarters, and students from other programs may be permitted to enroll with prior permission of the instructors.
Terms: Aut, Win, Spr, Sum | Units: 1 | Repeatable 12 times (up to 12 units total)

GENE 220: Introduction to Genetics, Ethics, and Society

Focus is on examining the past, present, and future relationship between human genetics and society to evaluate the ethical implications of the research we conduct. Students will reflect on their personal roles and biases in order to develop the tools needed to conduct equitable, just, and inclusive research. Topics include the intersection between science and society; history of American eugenics; community-engaged research; race, ancestry, and identity; forensic genetics; behavioral genetics; and reproductive genetics. Preference to graduate students and postdocs working with genetic technologies or concepts. Formerly offered as BIOS 232
Terms: Spr | Units: 1-2

GENE 222: Cloud Computing for Biology and Healthcare (BIOMEDIN 222, CS 273C)

Big Data is radically transforming healthcare. To provide real-time personalized healthcare, we need hardware and software solutions that can efficiently store and process large-scale biomedical datasets. In this class, students will learn the concepts of cloud computing and parallel systems' architecture. This class prepares students to understand how to design parallel programs for computationally intensive medical applications and how to run these applications on computing frameworks such as Cloud Computing and High Performance Computing (HPC) systems. Prerequisites: familiarity with programming in Python and R.
Terms: Spr | Units: 3

GENE 223: Aging: Science and Technology for Longevity

Is aging another disease that can be ultimately cured? We will look at the biology of aging, transitioning from the molecular level through to the cellular and systems level. What are age-related diseases, can lifespan be extended and are centenarians different? Additionally how can artificial intelligence create robotic and software assistants as we get older and is living forever is possible in any form ? Topics will include: molecular theories of aging, impact of oxidative stress, age-related diseases, artificial intelligence for longevity, and innovations to improve the quality of life as we age.
Terms: Spr | Units: 2-3

GENE 224: Principles of Pharmacogenomics (BIOMEDIN 224)

This course is an introduction to pharmacogenomics, including the relevant pharmacology, genomics, experimental methods (sequencing, expression, genotyping), data analysis methods and bioinformatics. The course reviews key gene classes (e.g., cytochromes, transporters) and key drugs (e.g., warfarin, clopidogrel, statins, cancer drugs) in the field. Resources for pharmacogenomics (e.g., PharmGKB, Drugbank, NCBI resources) are reviewed, as well as issues implementing pharmacogenomics testing in the clinical setting. Reading of key papers, including student presentations of this work; problem sets; final project selected with approval of instructor. Prerequisites: two of BIO 41, 42, 43, 44X, 44Y or consent of instructor.
Terms: Aut, Spr | Units: 3

GENE 232: Advanced Imaging Lab in Biophysics (APPPHYS 232, BIO 132, BIO 232, BIOE 232, BIOPHYS 232)

Laboratory and lectures. Advanced microscopy and imaging, emphasizing hands-on experience with state-of-the-art techniques. Students construct and operate working apparatus. Topics include microscope optics, Koehler illumination, contrast-generating mechanisms (bright/dark field, fluorescence, phase contrast, differential interference contrast), and resolution limits. Laboratory topics vary by year, but include single-molecule fluorescence, fluorescence resonance energy transfer, confocal microscopy, two-photon microscopy, microendoscopy, and optical trapping. Limited enrollment. Recommended: basic physics, basic cell biology, and consent of instructor.
Terms: Spr | Units: 4

GENE 268: Biology and Applications of CRISPR/Cas9: Genome Editing and Epigenome Modifications (BIOS 268)

This course is designed to provide a broad overview of the biology and applications of the revolutionary CRISPR/Cas9 system, with detailed exploration of several areas: / / --Basic biology of the CRISPR/Cas9 system / --High-throughput screening using CRISPR/Cas9 / --Epigenetic modifications and transcriptional regulation using dCas9 / --Therapeutic applications of gene editing with CRISPR / --Disease modeling with CRISPR / --Ethical considerations of the use of CRISPR/Cas9 / / The course will be geared toward advanced undergraduates and graduate students, and will assume a basic background in molecular biology and genetics. The course will be lecture-based, with frequent opportunities for discussion and questions.
Terms: Spr | Units: 1

GENE 274B: A Case Based Approach to Clinical Genetics

For genetic counseling students and medical genetics residents and fellows. Case-based scenarios and guest expert lectures. Students learn skills in case preparation, management, and presentation, as well as content around common genetic disorders. This course is a continuation of GENE 274A, but may be taken individually with instructor permission.
Terms: Spr | Units: 2
Instructors: ; Hanson-Kahn, A. (PI)

GENE 276: Genetic Counseling Fieldwork

For genetic counseling students only. Supervised clinical experiences. May be repeated for credit.
Terms: Aut, Win, Spr, Sum | Units: 1-7 | Repeatable for credit
Instructors: ; Hanson-Kahn, A. (PI)

GENE 278: Prenatal Genetic Counseling

Online course for genetic counseling students, graduate students in genetics, medical students, residents, fellows, and nurses interested in prenatal genetics. Genetic counseling students should take this course in conjunction with their initial prenatal genetics rotation. Topics include: prenatal screening and diagnostic testing, ultrasound, genetic carrier screening, teratology, fetal treatment and intervention, perinatal loss, termination, and infertility. Non-GC students: Please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1
Instructors: ; Campion, M. (PI)

GENE 279: Pediatric and Adult Genetic Counseling

Online course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their general genetics rotation. Topics include: clinical reasoning in medical genetics, techniques to prepare for the medical genetics visit, assessment of child development and medical history in the context of a genetic workup, dysmorphology, development of a differential diagnosis, and resources for case management and family support. Non-GC students: Please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1
Instructors: ; Hanson-Kahn, A. (PI)

GENE 280: Metabolic Genetic Counseling

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Genetic counseling students should take this course in conjunction with their metabolic genetics rotation. Topics include: overview of metabolic diseases; common pathways; diagnosis, management, and treatment of metabolic disorders; and newborn screening. Non-GC students: Please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1
Instructors: ; Hanson-Kahn, A. (PI)

GENE 281: Cancer Genetic Counseling

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their initial cancer genetics rotation. Topics include: cancer biology and cytogenetics; diagnosis and management of common cancer genetic syndromes; predictive testing; psychology of cancer genetic counseling; and topics recommended by ASCO guidelines.Non-GC students: Please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1
Instructors: ; Hanson-Kahn, A. (PI)

GENE 282B: Genetic Counseling Research Seminar

For genetic counseling students only. Lectures and facilitated discussions on research methodology for genetic counseling departmental research projects. Prerequisite: GENE 282A.
Terms: Spr | Units: 1
Instructors: ; Naik, H. (PI)

GENE 283: Genetic Counseling Research

Genetic counseling students conduct clinical research projects as required by the department for graduation. May be repeated for credit. Pre- or corequisite: GENE 282.
Terms: Aut, Win, Spr, Sum | Units: 1-8 | Repeatable for credit
Instructors: ; Naik, H. (PI)

GENE 284: Medical Genetics Seminar

Presentation of clinical and research topics in human genetics, followed by case presentations from the medical genetics and biochemical genetics services. Course may be completed online or in-person. Non-GC students: Please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1 | Repeatable for credit
Instructors: ; Campion, M. (PI)

GENE 285C: Genetic Counseling Seminar

Year-long seminar primarily for 1st-year genetic counseling students. Spring: This course will focus on honing students' counseling skills, taking into account the wide variety of ways that people approach the emotions and questions generated by chronic conditions or receiving a diagnosis. Various counseling and communication theories, models, and therapies will be discussed.
Terms: Spr | Units: 3
Instructors: ; Campion, M. (PI)

GENE 286: Advanced Genetic Counseling Seminar

For genetic counseling students only. This course aims to develop students' advanced counseling skills through formal analysis and discussion of their clinical experiences and integration of counseling theories. In addition, students will learn about relevant professional issues through a combination of presentations and activities. Must be taken for 3 quarters.
Terms: Aut, Win, Spr | Units: 2 | Repeatable 3 times (up to 6 units total)
Instructors: ; Campion, M. (PI)

GENE 287: CARDIOVASCULAR GENETICS

Online course for genetic counseling students, graduate students in genetics, medical students, residents, fellows, and nurses interested in inherited cardiovascular conditions. Genetic counseling students should take this course in conjunction with their cardiovascular genetics rotation. Topics include: Basic cardiology principles, including relevant anatomy and physiology; diagnosis, management and genetic testing as it relates to common inherited cardiovascular conditions in both the pediatric and adult setting; predictive genetic testing issues specific to inherited cardiovascular conditions; psychological issues related to sudden death conditions. Non-GC students: Please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1
Instructors: ; Campion, M. (PI)

GENE 288: Neurogenetics

Online, self-paced course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Topics include: Basic neurology principles, including relevant anatomy and physiology; diagnosis, management and genetic testing as it relates to common inherited neurological conditions in both the pediatric and adult setting; predictive genetic testing issues specific to inherited neurogenetic conditions. Non-GC students: Please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1
Instructors: ; Campion, M. (PI)

GENE 289: Variant Interpretation

Online, self-paced course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Topics include a review of mechanisms of pathogenicity, phenotype assessment, and technical aspects of variant filtering and prioritization, and gene curation. Attendees will become familiar with the types of evidence to support or refute pathogenicity and the standards in doing so, and will develop skills to critically assess literature and existing databases for variant classification. Non-GC students: Please contact the instructor when you enroll.
Terms: Aut, Win, Spr | Units: 1

GENE 290: Curricular Practical Training and Internship

CHPR masters students enroll for a letter grade in your mentor's section. Before the end of the second week of the quarter, enrolled students must submit a description of the expected learning outcomes and deliverables for each unit to the CHPR office. One unit= three hours of work per week (30 hours for the quarter). CHPR 290 is also the CPT Course required for international students completing degree requirements.
Terms: Win, Spr, Sum | Units: 1 | Repeatable 3 times (up to 3 units total)

GENE 346: Advanced Seminar in Microbial Molecular Biology (BIO 346, CSB 346)

Enrollment limited to PhD students associated with departmental research groups in genetics or molecular biology.
Terms: Aut, Win, Spr | Units: 1
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