Results for CSB

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

Introduces students to the instrumentation, experimental strategies, and computational methods used for identification and quantification of protein concentrations and posttranslational modifications on a systems-wide level. Topics include mass spectrometry (instrumentation configurations; polypeptide ionization; sample preparation and fractionation techniques; mass spectra interpretation; relative and absolute protein quantitation; and proteome-scale dataset analysis), protein and antibody arrays, multiparameter flow cytometry with Bayesian analysis, ribosomal protein translation profiling, and GFP and fluorescence imaging based quantification of protein abundance and post-translational modifications.

The scientific principles and technologies involved in making the transition from a basic biological observation to the creation of a new drug emphasizing molecular and genetic issues. Prerequisite: biochemistry, chemistry, or bioengineering.

Introductory course covering the basics of drug discovery and development. Topics include target identification and validation; identification of small molecule compounds that modulate the target of interest; properties of a drug development candidate; drug formulation, absorption, and pharmacokinetics; preclinical safety studies; drug manufacturing and quality assurance; human testing for safety and efficacy; and regulatory issues. Chemical and Systems Biology students may not take this class for credit in addition to CSB 240A.

Topics include mechanisms of DNA replication; gene expressions regulation; DNA damage sensing and DNA repair; chromatin structure and function; and epigenetics and nuclear reprogramming. Prerequisite: working knowledge of molecular biology, biochemistry and genetics, or instructor consent.

Guest speakers and discussion on current research in pharmacology.

Genetic analysis of the key regulatory circuits governing the control of cell division. Illustration of key principles that can be generalized to other synthetic and natural biological circuits. Focus on tractable model organisms; growth control; irreversible biochemical switches; chromosome duplication; mitosis; DNA damage checkpoints; MAPK pathway-cell cycle interface; oncogenesis. Analysis of classic and current primary literature. Satisfies Central Menu Area 2.

Prerequisite: consent of instructor.

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

The molecular mechanisms through which cells receive and respond to external signals. Emphasis is on principles of cell signaling, the systems-level properties of signal transduction modules, and experimental strategies through which cell signaling pathways are being studied. Prerequisite: working knowledge of biochemistry and genetics.

The principles of organic and physical chemistry as applied to biomolecules. Goal is a working knowledge of chemical principles that underlie biological processes, and chemical tools used to study and manipulate biological systems. Prerequisites: organic chemistry and biochemistry, or consent of instructor.

Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital.

(Continuation of 240A) Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Prerequisite: 240A.

Experimental and computational approaches to the dissection of complex biologcal systems. Topics include network structure, non-linear dynamics, numerical modeling approaches, noise, and robustness. Topics are introduced in the context of recent papers from the primary literature.