Results for BIOS

The emerging therapeutic landscape has a new cast of characters' engineered cells, programmable nucleic acids, and multi-valent antibodies' to name a few. This lecture-based course will provide an overview of these new therapeutic modalities, the basic science guiding their development, and a discussion of new regulatory and safety challenges that emerge in these modalities. As a final project, students will produce a report spanning the preclinical and clinical development of a new therapy. Examples include CRISPR-edited cell therapies, bispecific T cell engagers, in vivo CRISPR base editors, and antisense oligo therapies.

In evolutionary theory, the standard 'fitness' considers the operation of selection over a single generation. Some researchers use a poorly-quantified term, 'evolvability', to describe the latent ability of organisms to evolve over multiple generations. Does evolvability itself evolve? Can we tease apart the concepts of short-term fitness and long-term evolvability? Can we quantitatively define a 'long-term fitness' that is as general and practical as the standard fitness? What entities (individuals? genotypes? species?) can be said to possess evolvability? This seminar will debate these questions as we study papers ranging from theoretical biology, to concepts in "evo-devo", to recent experimental work in microbiology and in silico models.

Introduction to the social science literature on factors contributing to gender disparities in the scientific workplace (e.g. implicit bias and stereotype threat). Discussions focus on steps that individuals and institutions can take to promote the advancement of women and other underrepresented groups in science, and thus promote the advancement of science.

"Open Source Prototyping" is a hands-on course that equips students with the skills and knowledge to use open-source design tools and rapid prototyping technologies, such as 3D printing and CNC. Students will learn how to translate their ideas into real-world objects, understanding the full process from ideation to realization. Key topics include navigation of leading design software, 3D printing technologies, and in-depth understanding of materials science. The course emphasizes open-source principles, and their applications in additive manufacturing. It features a wide range of applications, including medical devices, lab equipment, and experimental apparatuses, providing a comprehensive look at prototyping potential.

Three-week course at Hopkins Marine Station. Focuses on the embryology and larval development of a broad range of marine invertebrate phyla. The goal of the course is to give students an appreciation of the range of developmental strategies and larval forms in the ocean and why this is critical for constructing hypotheses of EvoDevo and animal evolution. Includes observation and documentation of the development of embryos and larvae by scientific illustration and photo/video microscopy. Pre-requisite: Developmental Biology coursework and instructor consent.

This course will examine the historical and contemporary roles that the cultural norms and practices across STEM domains (¿Culture of Science¿) have played in advancing persistent gender and racial/ethnic STEM inequities in the postsecondary context and beyond. By doing so this course will allow students to employ an interdisciplinary lens to begin to critically explore the impact that "Culture of Science" may have on the development and expression an individual's "Science Identity".

Graduate students in the Biosciences PhD Programs develop a fellowship proposal (e.g. NIH F31) focusing on required documents: 1-page specific aims as well as research and career development plans. Students establish a writing practice and learn fundamental grant writing skills through guided exercises, including in-class review and focused faculty feedback.

This course is designed to provide a broad overview of the biology and applications of the revolutionary CRISPR/Cas9 system, with detailed exploration of several areas: / / --Basic biology of the CRISPR/Cas9 system / --High-throughput screening using CRISPR/Cas9 / --Epigenetic modifications and transcriptional regulation using dCas9 / --Therapeutic applications of gene editing with CRISPR / --Disease modeling with CRISPR / --Ethical considerations of the use of CRISPR/Cas9 / / The course will be geared toward advanced undergraduates and graduate students, and will assume a basic background in molecular biology and genetics. The course will be lecture-based, with frequent opportunities for discussion and questions.

This 9-week Proposal Bootcamp guides grant writers through the process of developing a compelling fellowship (e.g., NIH F31, F32) or career development award (e.g., NIH K99/R00, K01, K08, etc.). Participants gain new grant writing skills through synchronous, including Mini Lectures and Grant Coach Office Hours, and asynchronous, including recorded videos and readings, activities. Students and postdocs join our award-winning peer review program for feedback on key proposal documents. This Bootcamp is 100% remote and open to all Stanford affiliates.

Design a fulfilling and impactful vision for your career and life as a whole. The primary purpose of the class is to develop a perspective and align your attitudes, actions and experiences with your values, priorities, and your own ultimate definition of victory for living an extraordinary life. A practical guide for career development, this class will provide training through conversations, self-analysis, and writing exercises on career direction, communication, and the development and leveraging of relationships skills that are central to success in any career as a scientist. We will examine what it means (and what it takes) to succeed in a variety of life domains, including money, health, career, relationships, and physical fitness as well as personal growth. We will dig into the darker side of being human, exploring phenomena like negative character traits, fears, hauntings, and regrets. Ultimately, we want you to gain insight into who you are, what you want most, and how you might inadvertently and unwittingly get in your own way. We want you to learn how to confront the most vexing issues in your life, learn from them, and eventually transform your relationship to them. Course Structure: The course consists of ten intensive, flipped-classroom sessions designed to help you develop the skills and knowledge--and, more importantly, the insight and capacity--to be more strategic and effective in how you lead your life. It requires a willingness to be introspective and to consider personal feedback and constructive confrontation. Enrollment is capped at 30 learners, all of whom will be provided subscriptions to Inner.U which will serve as an electronic textbook and supported by a team of three faculty facilitators.

This mini-course will explore how bias influences science at different levels, from entire fields to individual experiments. Students will learn about how biases in biological research limit scientific productivity and knowledge. Classes will consist of short lectures and student-led discussions using case studies from pain research, plus examples from students? own research fields. The class will prioritize active learning and self-examination, and will include a small final project. The goal of the class is for students to come away with a deeper understanding of scientific bias and use that information to critique their own science and dogmas in their field.

In this mini-course, we delve into the cutting-edge realm of microfluidics, covering governing physics for fluid flow, various microfabrication techniques and their applications in biomedicine. Topics include microfluidics for cell/particle separation, micromixers, droplet-based microfluidics, and organ-on-a-chip technology. You will gain a deep understanding of the fundamental principles, get knowledge about different microfluidic devices, and explore the world of organ-on-a-chip models for drug screening and disease modeling. This mini-course also includes a hands-on laboratory session where you will have the opportunity to fabricate microfluidic devices and get familiar with experimental setup.

This course delves into the fundamental principles of Deep Learning within the medical field, designed to offer a thorough yet accessible introduction to how these advanced models function, are developed, and are currently transforming healthcare practices. The curriculum covers key areas including neural network architecture, computer vision, natural language processing, convolutional neural networks, alongside classification and regression techniques, aiming to provide students with a solid foundation and intuitive insight into the workings of deep learning applications in medicine.In addition to the core content, participants will have the opportunity to engage with expert-led discussions on the latest advancements and future directions at the intersection of artificial intelligence and medicine.

The course will introduce large-scale spatiotemporal patterns in the neural activities of human brain and their relevance to cognitive functions and neurological diseases. whole-brain neural activities, which can be measured by fMRI or M/EEG, do not fluctuate randomly, but form specific spatiotemporal patterns that are highly reproducible across different conscious states, and are often referred to as functional networks. In the course, the students will learn some of the state-of-art methods of capturing these patterns and evaluate their significance in normal and abnormal brain functions. Zoom attendance is possible but in-person attendance is recommended. There will be in-class practice involving coding and data manipulation, attending in person allows the instructor to help the students debug at the site.

If you?re looking to use your Biosciences knowledge or interests in engineering and medicine to create health innovations that solve some of the world?s most pressing health problems. This course will give you the tools and skills you need to start this process. The course will focus on the basics of user research, design and prototyping for innovations that can have an impact on health equity outcomes. We will take an interdisciplinary approach to solving these problems, and discuss how to build collaborative and inclusive partnerships for health innovations

This 2-week mini course will provide an introduction to commonly used techniques in immunology. Students will gain the confidence and relevant background to understand current immunology literature and design/analyze their own experiments. Topics for discussion will include flow cytometry, cytokine/antibody assays, animal models, specific sequencing pipelines, and more. Classes will be lecture-based with the opportunity to explore applications of these techniques related to students? own research interests. As this will be an introductory course, all immunology backgrounds are welcome.

This 3-week mini-course is intended for graduate students and postdocs who are interested in learning how to responsibly share their research data. Through this course, participants will build an in-depth understanding of the benefits of and challenges to sharing research data from human subjects and the current regulatory landscape of research data sharing (e.g., Common Rule, HIPAA, and the new NIH Data Management and Sharing Policy), including data de-identification. By the end of the course, participants will have developed their own plan for data sharing.

Matrix methods provide powerful tools for understanding and managing ecological systems and are frequently used for analysis of population dynamics. This course is intended to introduce matrix model calculus and its implications within an ecological context. This six-day course will be divided into lectures and workshops focused on simplifying matrix methods and for researchers to apply their gained skills on a set of data. Biologists with individual based data (i.e., life history transitions) are encouraged to sign-up. The course is computational based and all levels of RStudio are welcome.