Results for MI

Innate immune mechanisms as the only defenses used by the majority of multicellular organisms. Topics include Toll signaling, NK cells, complement, antimicrobial peptides, phagocytes, neuroimmunity, community responses to infection, and the role of native flora in immunity. How microbes induce and defeat innate immune reactions, including examples from vertebrates, invertebrates, and plants.

Focus on interaction of humans and viruses from a number of perspectives: historical, cultural, political, and demographic. Organismal, molecular biological, biochemical, human and viral interactions; clinical aspects of viral disease, epidemiology and risk factors, public and international health, aspects of virology including emerging viruses and biological weapons. Case studies involving particular viruses: human herpes viruses, retroviruses, oncogenic viruses; vaccination and disease eradication, evolution of viruses as tools for research and therapy. Emphasis on general principles of biology and matters of decision making policy. Prerequisite: Biology core, Human Biology core, or consent of instructor.

Case studies related to the evolutionary origins of smallpox, monkeypox, and other emerging pox infections. Topics include public health policy, socio-cultural factors related to pox eradication, research funding, and the use of pox viruses in bioterrorism and as vectors for gene therapy. Fieldtrips and guest speakers on the development of novel drugs, personal accounts of the eradication efforts, current clinical trials for pox vaccines, and current laboratory studies of pox.

For advanced undergraduates and graduate students. Topics include diversity, molecular regulation, growth, bioenergetics, and unique matabolic processes. Presentation of student papers on current topic selected with student input. Satisfies Central Menu Area 3 for Bio majors. Prerequisites: CHEM 31X, Biology core.

Fields of study are decided in consultation with sponsoring professor. Prerequisite: consent of instructor.

Investigations sponsored by individual faculty members. Possible fields: microbial molecular biology and physiology, microbial pathogenicity, immunology, virology, and molecular parasitology. Prerequisite: consent of instructor.

Innate immune mechanisms as the only defenses used by the majority of multicellular organisms. Topics include Toll signaling, NK cells, complement, antimicrobial peptides, phagocytes, neuroimmunity, community responses to infection, and the role of native flora in immunity. How microbes induce and defeat innate immune reactions, including examples from vertebrates, invertebrates, and plants.

For graduate and medical students, and advanced undergraduates; required of first-year graduate students in Microbiology and Immunology. The molecular mechanisms by which microorganisms invade animal and human hosts, express their genomes, interact with macromolecular pathways in the infected host, and induce disease. Current literature.

For graduate and medical students and advanced undergraduates. Molecules and cells of the innate and adaptive immune systems; genetics, structure, and function of immune molecules; lymphocyte differentiation and activation; regulation of immune responses; autoimmunity and other problems in immune system dysfunction. Prerequisites: undergraduate course in Immunology and familiarity with experimental approaches in biochemistry, molecular biology, and cell biology.

The principles underlying commonly utilized technical procedures in biological research. Lectures and primary literature critiques on gel electrophoresis, protein purification and stabilization, immunofluorescence microscopy, FACS. Prerequisites: biochemistry. Required of first-year graduate students in Microbiology and Immunology, and the Immunology program.

Focus on interaction of humans and viruses from a number of perspectives: historical, cultural, political, and demographic. Organismal, molecular biological, biochemical, human and viral interactions; clinical aspects of viral disease, epidemiology and risk factors, public and international health, aspects of virology including emerging viruses and biological weapons. Case studies involving particular viruses: human herpes viruses, retroviruses, oncogenic viruses; vaccination and disease eradication, evolution of viruses as tools for research and therapy. Emphasis on general principles of biology and matters of decision making policy. Prerequisite: Biology core, Human Biology core, or consent of instructor.

Open to graduate and medical students. How recent discoveries of miRNA, RNA interference, and short interfering RNAs reveal potentially widespread gene regulatory mechanisms mediated by small modulatory RNAs during animal and plant development. Required paper proposing novel research.

Required of first- and second-year students in Microbiology and Immunology. How to evaluate biological research. Held in conjunction with the Microbiology and Immunology Friday noon seminar series. Before the seminar, students and faculty discuss one or more papers from the speaker's primary research literature on a related topic. After the seminar, students meet informally with the speaker to discuss their research.

For advanced undergraduates and graduate students. Topics include diversity, molecular regulation, growth, bioenergetics, and unique matabolic processes. Presentation of student papers on current topic selected with student input. Satisfies Central Menu Area 3 for Bio majors. Prerequisites: CHEM 31X, Biology core.

Prerequisite: consent of instructor.

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.

Students who have completed the necessary foundation courses undertake investigations in general bacteriology, bacterial physiology and ecology, bacterial genetics, microbial pathogenicity, immunology, parasitology, or virology sponsored by individual faculty members. Prerequisite: consent of instructor.

Advanced seminar. Human aspects of viral disease, focusing on recent discoveries in vaccine development and emerging infections. Journal club format: students choose articles from primary scientific literature, write formal summaries, and synthesize them into a literature review. Emphasis is on analysis, experimental design, and interpretation of data. Oral presentations. Enrollment limited to 10. Prerequisites: HUMBIO 155H, MI 155V.

Introduction to human virology integrating epidemiology, molecular biology, clinical sciences, social sciences, history, and the arts. Emphasis is on host pathogen interactions and policy issues. Topics: polio and vaccination, smallpox and eradication, yellow fever and history, influenza and genomic diversity, rubella and childhood infections, adenovirus and viral morphology, ebola and emerging infection, lassa fever and immune response.

Introduction to human virology integrating epidemiology, molecular biology, clinical sciences, social sciences, history, and the arts. Emphasis on host pathogen interactions and policy issues. Topics: measles and viral epidemiology, rotavirus and world health, rabies and infections of the brain, HPV and cancer -causing viruses, herpes simplex and viral latency, CMV and viral teratogenesis, retrovirology and endogenous viral sequences, HIV and viral treatement, viral hepatitis and chronic infections, prions and diseases of life style. Prerequisite: MI155H.

For graduate or medical students and (if space allows) to active participants from other segments of the Stanford Community (e.g., TGR students); undergraduates by instructor consent. Fundamental issues of RNA biology, with the goal of setting a foundation for students to explore the expanding world of RNA-based regulation. Each week a topic is covered by a faculty lecture and journal club presentations by students.