Results for CSB

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

The molecular mechanisms through which cells receive and respond to external signals. Emphasis is on principles of cell signaling, the systems-level properties of signal transduction modules, and experimental strategies through which cell signaling pathways are being studied. Prerequisite: working knowledge of biochemistry and genetics.

The scientific principles and technologies involved in making the transition from a basic biological observation to the creation of a new drug emphasizing molecular and genetic issues. Prerequisite: biochemistry, chemistry, or bioengineering.

Provides an overview of the drug discovery and development process through use of case examples--successful and unsuccessful attempts to integrate the scientific, clinical, regulatory, and commercial requirements to bring a new drug to patients. Focus on the complex array of independent tasks that must be accomplished to bring a new drug to the clinic. Specific cases discussed in a seminar format.

Focuses on translation of promising research discovery into marketed drugs and the integration of scientific method, clinical needs assessment, clinical and regulatory strategy, market analysis, economic considerations, and the influence of the healthcare economic ecosystem necessary for successful translation. Explores the economic perspectives of various stakeholders--patients, providers, payers, biotechnology and pharmaceutical companies, FDA, and financial markets--and how they influence drug development.

Topics include mechanisms of DNA replication; gene expressions regulation; DNA damage sensing and DNA repair; chromatin structure and function; and epigenetics and nuclear reprogramming. Prerequisite: working knowledge of molecular biology, biochemistry and genetics, or instructor consent.

Guest speakers and discussion on current research in pharmacology.

Prerequisite: consent of instructor.

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

The principles of organic and physical chemistry as applied to biomolecules. Goal is a working knowledge of chemical principles that underlie biological processes, and chemical tools used to study and manipulate biological systems. Prerequisites: organic chemistry and biochemistry, or consent of instructor.

Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Maximum units are available by taking an additional contact hour.

(Continuation of 240A) Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Maximum units are available by taking an additional contact hour. Prerequisite: 240A.

Genetic analysis of the key regulatory circuits governing the control of cell division. Illustration of key principles that can be generalized to other synthetic and natural biological circuits. Focus on tractable model organisms; growth control; irreversible biochemical switches; chromosome duplication; mitosis; DNA damage checkpoints; MAPK pathway-cell cycle interface; oncogenesis. Analysis of classic and current primary literature. Satisfies Central Menu Area 2.