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BIOC 118Q: Genomics and Medicine

Preference to sophomores. Knowledge gained from sequencing human genomes and implications for medicine and biomedical research. Novel diagnoses and treatment of diseases, including stem cells, gene therapy and rational drug design. Personal genomics and how it is used to improve health and well being. Social and ethical implications of genetic information such as privacy, discrimination and insurability. Course Webpage: http://biochem118.stanford.edu/.
Terms: Aut | Units: 3 | UG Reqs: GER: DB-NatSci, WAY-SMA
Instructors: ; Brutlag, D. (PI)

BIOC 158: Genomics, Bioinformatics and Medicine (BIOC 258, BIOMEDIN 258, HUMBIO 158G)

Molecular basis of inherited human disease. Diagnostics approaches: simple Mendelian diseases and complex, multifactorial diseases. Genomics: functional genomics, epigenetics, gene expression, SNPs, copy number and other structural genomic variations involved in disease. Novel therapeutic methods: stem cell therapy, gene therapy and drug developments that depend on the knowledge of genomics. Personal genomics, pharmacogenomics, clinical genomics and their role in the future of preventive medicine. Prerequisites: BIO 41 or HUMBIO 2A or consent of instructor. Those with credit in BIOC 118 not eligible to enroll. Course webpage: http://biochem158.stanford.edu/
Terms: Aut, Win, Spr | Units: 3 | UG Reqs: GER: DB-NatSci, WAY-SMA | Repeatable 2 times (up to 6 units total)
Instructors: ; Brutlag, D. (PI)

BIOC 199: Undergraduate Research

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit

BIOC 200: Applied Biochemistry

Enrollment limited to MD candidates. Fundamental concepts of biochemistry as applied to clinical medicine. Topics include vitamins and cofactors, metabolism of carbohydrates, lipids, amino acids and nucleotides, and the integration of metabolic pathways. Clinical case studies discussed in small-group, problem-based learning sessions.
Terms: Aut | Units: 2

BIOC 202: Biochemistry Bootcamp

Open to first year Biochemistry students or consent of instructor. Hands-on, five-day immersion in biochemical methods and practice, theory and application of light microscopy, and computational approaches to modern biological problems.
Terms: Aut | Units: 1
Instructors: ; Theriot, J. (PI)

BIOC 205: Molecular Foundations of Medicine

For medical students. Topics include DNA structure, replication, repair, and recombination; gene expression, including mechanisms for regulating transcription and translation; chromosome structure and function; gene cloning, protein engineering, and genomics. Patient presentations and journal clubs illustrate how molecular biology affects the practice of medicine.
Terms: Aut | Units: 3

BIOC 218: Computational Molecular Biology (BIOMEDIN 231)

Practical, hands-on approach to field of computational molecular biology. Recommended for molecular biologists and computer scientists desiring to understand the major issues concerning analysis of genomes, sequences and structures. Various existing methods critically described and strengths and limitations of each. Practical assignments utilizing tools described. Prerequisite: BIO 41 or consent of instructor. All homework and coursework submitted electronically. Course webpage: http://biochem218.stanford.edu/.
Terms: Aut, Win, Spr | Units: 3
Instructors: ; Brutlag, D. (PI)

BIOC 221: The Teaching of Biochemistry

Required for teaching assistants in Biochemistry. Practical experience in teaching on a one-to-one basis, and problem set design and analysis. Familiarization with current lecture and text materials; evaluations of class papers and examinations. Prerequisite: enrollment in the Biochemistry Ph.D. program or consent of instructor.
Terms: Aut, Win, Spr, Sum | Units: 3 | Repeatable for credit

BIOC 257: Currents in Biochemistry

Seminars by Biochemistry faculty on their ongoing research. Background, current advances and retreats, general significance, and tactical and strategic research directions.
Terms: Aut | Units: 1
Instructors: ; Spudich, J. (PI)

BIOC 258: Genomics, Bioinformatics and Medicine (BIOC 158, BIOMEDIN 258, HUMBIO 158G)

Molecular basis of inherited human disease. Diagnostics approaches: simple Mendelian diseases and complex, multifactorial diseases. Genomics: functional genomics, epigenetics, gene expression, SNPs, copy number and other structural genomic variations involved in disease. Novel therapeutic methods: stem cell therapy, gene therapy and drug developments that depend on the knowledge of genomics. Personal genomics, pharmacogenomics, clinical genomics and their role in the future of preventive medicine. Prerequisites: BIO 41 or HUMBIO 2A or consent of instructor. Those with credit in BIOC 118 not eligible to enroll. Course webpage: http://biochem158.stanford.edu/
Terms: Aut, Win, Spr | Units: 3 | Repeatable 2 times (up to 6 units total)
Instructors: ; Brutlag, D. (PI)

BIOC 350: Development of Thesis Research

Biochemistry 2nd year PhD students with permission of instructor only. Students place their thesis research into a broader scientific perspective, identify important questions to ask, and learn to communicate these clearly. The course includes a series of roundtable discussions with students and faculty about the students' proposed research topics. The initial focus is on developing the equivalent of a specific aims page for a research grant.
Terms: Aut | Units: 2 | Repeatable 2 times (up to 4 units total)

BIOC 360: Developing an Original Research Proposal

Biochemistry 3rd year PhD students with permission of instructor only. Students develop new research directions. Topics well outside of student's research topic must be chosen. Series of discussion groups with faculty and students. Students present possible outside research topics followed by presentation of important questions and approaches to answer these questions. Focus is on developing the equivalent of specific aims for research grants.
Terms: Aut, Win | Units: 1 | Repeatable 3 times (up to 3 units total)

BIOC 370: Medical Scholars Research

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.
Terms: Aut, Win, Spr, Sum | Units: 4-18 | Repeatable for credit

BIOC 399: Graduate Research and Special Advanced Work

Allows for qualified students to undertake investigations sponsored by individual faculty members.
Terms: Aut, Win, Spr, Sum | Units: 1-18 | Repeatable for credit

BIOC 459: Frontiers in Interdisciplinary Biosciences (BIO 459, BIOE 459, CHEM 459, CHEMENG 459, PSYCH 459)

Students register through their affiliated department; otherwise register for CHEMENG 459. For specialists and non-specialists. Sponsored by the Stanford BioX Program. Three seminars per quarter address scientific and technical themes related to interdisciplinary approaches in bioengineering, medicine, and the chemical, physical, and biological sciences. Leading investigators from Stanford and the world present breakthroughs and endeavors that cut across core disciplines. Pre-seminars introduce basic concepts and background for non-experts. Registered students attend all pre-seminars; others welcome. See http://biox.stanford.edu/courses/459.html. Recommended: basic mathematics, biology, chemistry, and physics.
Terms: Aut, Win, Spr | Units: 1 | Repeatable for credit
Instructors: ; Robertson, C. (PI)
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