Results for CSB

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

In this "boot camp" students perform hands-on original research in small groups, combining chemical biology systems-level approaches to investigate current biological problems. This year's course will investigate the function and regulation of uncharacterized genes. Students will acquire conceptual and methodological training in a wide range of modern techniques, including "omics" approaches, fluorescence microscopy, genome editing, computational approaches, and quantitative data analysis.

The molecular mechanisms through which cells receive and respond to external signals. Emphasis is on principles of cell signaling, the systems-level properties of signal transduction modules, and experimental strategies through which cell signaling pathways are being studied. Prerequisite: working knowledge of biochemistry and genetics.

This course explores principles of logic, experimental design, and methods across the Biosciences, centered on case studies from both classic and modern literature. In collaboration with faculty, students also apply those principles to develop a research project, presented in both written and oral form.

Required of and limited to all graduate students and postdoctoral scholars in the Department of Chemical and Systems Biology. Students and postdocs are required to give in-depth presentations about their current projects within the academic year.

Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Maximum units are available by taking an additional contact hour.

(Continuation of 240A) Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Maximum units are available by taking an additional contact hour. Prerequisite: 240A.

The scientific principles and technologies involved in making the transition from a basic biological observation to the creation of a new drug emphasizing molecular and genetic issues. Prerequisite: biochemistry, chemistry, or bioengineering.

This course will introduce students to the applications of biotechnology to the discovery and development of novel drugs and therapeutics. Students will learn about the process of drug discovery and development from target discovery, through drug optimization, preclinical testing, clinical testing, and commercialization. The course also offers a basic understanding of functions that work in parallel with discovery research and drug development, including business strategy, portfolio decision-making and program management. Finally, the course allows the opportunity to learn from, and connect with leaders from companies within the Biotchnology sector. Please register your interest on Handshake (https://app.joinhandshake.com/events/811414) and we will contact you with a permission code if accepted into the course. Please email Stephanie (seberle@stanford.edu) with any further questions.

Focuses on translation of promising research discovery into marketed drugs and the integration of scientific method, clinical needs assessment, clinical and regulatory strategy, market analysis, economic considerations, and the influence of the healthcare economic ecosystem necessary for successful translation. Explores the economic perspectives of various stakeholders--patients, providers, payers, biotechnology and pharmaceutical companies, FDA, and financial markets--and how they influence drug development.

Topics include mechanisms of DNA replication; gene expressions regulation; DNA damage sensing and DNA repair; chromatin structure and function; and epigenetics and nuclear reprogramming. Prerequisite: working knowledge of molecular biology, biochemistry and genetics, or instructor consent.

Current topics include chemical genetics, activity-based probes, inducible protein degradation, DNA/RNA chemistry and molecular evolution, protein labeling, carbohydrate engineering, fluorescent proteins and sensors, optochemical/optogenetic methods, mass spectrometry, and genome-editing technologies.

Students discuss readings focused on chemical and systems biology assigned by corresponding faculty host. Course held before corresponding Friday Cutting Lecture Series speaker. Please contact Student Services with any questions regarding the course administration. Required for CSB first and second year students. Open to all CSB students.

The systems biology set of courses aims to give students an overview of how cells process information to build and replicate themselves as well as respond to extracellular signals and environmental changes. The techniques used and discussed in detail are those currently utilized in modern quantitative cell biology. This course in the systems biology set aims to provide an understanding of the principles of cell signaling as applied to natural and synthetic biological circuits. As a primary example of naturally occurring signaling circuits, we will consider in detail the pathway responsible for controlling cell division in response to intra- and extra-cellular signals. The class will cover classic and current techniques for the genetic analysis of the key regulatory circuits governing the control of cell division. Specific topics include tractable model organisms; growth control; and irreversible biochemical switches. The class will be based on a weekly lecture followed by the analysis of classic and current primary literature as well as basic concepts in nonlinear dynamics.

CPT Course required for international students completing degree requirements.

Prerequisite: consent of instructor.

Enrollment limited to PhD students associated with departmental research groups in genetics or molecular biology.

Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.