Results for GENE

Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

For PhD students in any of the Biosciences Departments and Programs at Stanford University. Emphasis on developing the ability to solve problems using genetic ideas and methods, to understand the nature and reliability of genetic inference, and to apply genetic reasoning to biological research. Weekly paper discussions based on original research papers that define or illustrate the ideas and techniques covered in the lecture.

The goal of this course is to explore different genomic approaches and technologies, to learn how they work from a molecular biology view point, and to understand how they can be applied to understanding biological systems. In addition, we teach material on how the data generated from these approaches can be analyzed, from an algorithmic perspective. The papers that are discussed are a mixture of algorithmic papers, and technological papers.

Students analyze cutting edge science, develop a logical framework for evaluating evidence and models, and enhance their ability to design original research through exposure to experimental tools and strategies. The class runs in parallel with the Frontiers in Biological Research seminar series. Students and faculty meet on the Tuesday preceding each seminar to discuss a landmark paper in the speaker's field of research. Following the Wednesday seminar, students meet briefly with the speaker for a free-range discussion which can include insights into the speakers' paths into science and how they pick scientific problems.

Analytic and interpretive methods to optimize the transformation of genetic, genomic, and biological data into diagnostics and therapeutics for medicine. Topics: access and utility of publicly available data sources; types of genome-scale measurements in molecular biology and genomic medicine; linking genome-scale data to clinical data and phenotypes; and new questions in biomedicine using bioinformatics. Case studies. Prerequisites: programming ability at the level of CS 106A and familiarity with statistics and biology.

Current Issues in Genetics is an in-house seminar series that meets each Academic Quarter for one hour per week (Friday, 4:00-5:00) and features talks by Genetics Department faculty, students, and postdoctoral fellows (with occasional visiting speakers). Thus, over the year, it provides a comprehensive overview of the work going on in the Department. First-year Ph.D. students in Genetics are required to enroll during all four Quarters, and students from other programs may be permitted to enroll with prior permission of the instructors.

This course presents fundamental concepts and methods in genetic epidemiology, with examples from genetic studies of common, complex diseases (e.g., cancer). It will provide an overview of various study designs and covers fundamental analyses, inferences, and their strengths and limitations. The course will cover the following topics: assessing genetic influences on disease (e.g., heritability); family- and population-based association study designs; candidate gene and genome-wide association studies of common and rare genetic variants; transcriptome-wide association studies; polygenic risk scores; bias due to population stratification; gene-environment interactions and epistasis; studies of diverse populations; software and web-based data resources; ethical issues in genetic epidemiology; and applications of genetic epidemiology to clinical practice and public health. Guest speakers will discuss these concepts through the lens of various diseases. The course will include a project proposal based on student's research interests. Prerequisite: introductory biostatistics, epidemiology, and/or genetics (or by permission of the instructor).

How will AI help medicine but how could it harm us. This course will provide a high-level overview of AI techniques. Through pre-built hands-on exercises, we will cover neural networks and their applicability to generative AI and large language models. We will also discuss the societal and ethical issues surrounding the real-world applications of AI. This course is healthare oriented, looking at the intersection of AI and Genetics to analyze advances that could be made but also ethical questions that should be asked. The course is designed to be accessible to many disciplines and there are no pre-requisites.

This course will cover genetic and complementary approaches toward understanding and mitigating the emergence of new viral epidemics. Topics are: I. Viral Emergence ('Viral life in prebiotic soup', 'emergence in cellular contexts', 'viruses from viruses', 'viruses and their non-viral cousins'), II. Emergent Virology ('tracking the virome', 'genomics of recent viral pandemics', and 'the spectrum of viral malevolence'), and III. The Virome Interface ('environmental influences on viral epidemics', 'viruses, genes, and human behavior', 'big data in the service of controlling epidemics', and 'genetic approaches to viral treatment')

This course will cover a range of genetic and genomic approaches to studying human phenotypic variation and disease. We will discuss the genetic basis of Mendelian and complex diseases, as well as clinical applications including prenatal testing, and pediatric and cancer diagnostics. The course will include lectures as well as critical reading and discussion of the primary literature. Prerequisite: BIO 82 or equivalent. Open to advanced undergraduate students.

Genetics graduate student lab research from first quarter to filing of candidacy. Prerequisite: consent of instructor.

For genetic counseling students and medical genetics residents and fellows. Students learn skills in case preparation, management, and presentation, as well as content around common genetic disorders by presenting case-based scenarios and attending guest expert lectures..

For genetic counseling students only. Supervised clinical experiences. May be repeated for credit.

Online course for genetic counseling students, graduate students in genetics, medical students, residents, fellows, and nurses interested in prenatal genetics. Genetic counseling students should take this course in conjunction with their initial prenatal genetics rotation. Topics include: prenatal screening and diagnostic testing, ultrasound, genetic carrier screening, teratology, fetal treatment and intervention, perinatal loss, termination, and infertility. Non-GC students: Please contact the instructor when you enroll.

Online course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their general genetics rotation. Topics include: clinical reasoning in medical genetics, techniques to prepare for the medical genetics visit, assessment of child development and medical history in the context of a genetic workup, dysmorphology, development of a differential diagnosis, and resources for case management and family support. Non-GC students: Please contact the instructor when you enroll.

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Genetic counseling students should take this course in conjunction with their metabolic genetics rotation. Topics include: overview of metabolic diseases; common pathways; diagnosis, management, and treatment of metabolic disorders; and newborn screening. Non-GC students: Please contact the instructor when you enroll.

Internet based course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows; genetic counseling students should take this course in conjunction with their initial cancer genetics rotation. Topics include: cancer biology and cytogenetics; diagnosis and management of common cancer genetic syndromes; predictive testing; psychology of cancer genetic counseling; and topics recommended by ASCO guidelines.Non-GC students: Please contact the instructor when you enroll.

For genetic counseling students only. Facilitated discussions on identifying a topic and mentor for genetic counseling departmental research projects.

Genetic counseling students conduct clinical research projects as required by the department for graduation. May be repeated for credit. Pre- or corequisite: GENE 282.

Presentation of clinical and research topics in human genetics, followed by case presentations from the medical genetics and biochemical genetics services. Course may be completed online or in-person. Non-GC students: Please contact the instructor when you enroll.

Year-long seminar primarily for 1st-year genetic counseling students. Winter: Students will learn about the impact of genetic conditions at various points in the lifecycle, as well as the impact of genetic counseling during infertility or during the diagnosis of a genetic condition in the neonatal period, childhood, adolescence, or adulthood.

For genetic counseling students only. This course aims to develop students' advanced counseling skills through formal analysis and discussion of their clinical experiences and integration of counseling theories. In addition, students will learn about relevant professional issues through a combination of presentations and activities. Must be taken for 3 quarters.

Online course for genetic counseling students, graduate students in genetics, medical students, residents, fellows, and nurses interested in inherited cardiovascular conditions. Genetic counseling students should take this course in conjunction with their cardiovascular genetics rotation. Topics include: Basic cardiology principles, including relevant anatomy and physiology; diagnosis, management and genetic testing as it relates to common inherited cardiovascular conditions in both the pediatric and adult setting; predictive genetic testing issues specific to inherited cardiovascular conditions; psychological issues related to sudden death conditions. Non-GC students: Please contact the instructor when you enroll.

Online, self-paced course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Topics include: Basic neurology principles, including relevant anatomy and physiology; diagnosis, management and genetic testing as it relates to common inherited neurological conditions in both the pediatric and adult setting; predictive genetic testing issues specific to inherited neurogenetic conditions. Non-GC students: Please contact the instructor when you enroll.

Online, self-paced course for genetic counseling students, graduate students in genetics, medical students, residents, and fellows. Topics include a review of mechanisms of pathogenicity, phenotype assessment, and technical aspects of variant filtering and prioritization, and gene curation. Attendees will become familiar with the types of evidence to support or refute pathogenicity and the standards in doing so, and will develop skills to critically assess literature and existing databases for variant classification. Non-GC students: Please contact the instructor when you enroll.

CHPR masters students enroll for a letter grade in your mentor's section. Before the end of the second week of the quarter, enrolled students must submit a description of the expected learning outcomes and deliverables for each unit to the CHPR office. One unit= three hours of work per week (30 hours for the quarter). CHPR 290 is also the CPT Course required for international students completing degree requirements.

Prerequisite: consent of instructor.

Enrollment limited to PhD students associated with departmental research groups in genetics or molecular biology.

Investigations sponsored by individual faculty members. Prerequisite: consent of instructor.