BIOMEDIN 224:
Principles of Pharmacogenomics (GENE 224)
Introduction to the relevant pharmacology, genomics, experimental methods for high-throughput measurements (sequencing, expression, genotyping), analysis methods for GWAS, chemoinformatics, and natural language processing. Review of key gene classes (cytochromes, transporters, GPCRs), key drugs for which genetics is critical (warfarin, clopidogrel, statins, NSAIDs, neuropsychiatric drugs and cancer drugs). Also reviews resources for pharmacogenomics (PharmGKB, Drugbank, CMAP, and others) as well as issues in doing clinical implementation of pharmacogenomics testing. Reading of key papers, including student presentations of this work. Problem sets; final project selected with approval of instructor. Prerequisites: two of BIO 41, BIO 42, BIO 43, BIO 44X, BIO 44Y or consent of instructor.
| Units: 3