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Introduction to Computational Biology through an informatic exploration of the Human Genome. Topics include: Genome Sequencing - technologies, assembly, personalized sequencing; Functional landscape - genes, gene regulation, repeats, RNA genes, epigenetics; Genome evolution - comparative genomics, ultraconservation, co-option. Additional topics may include population genetics, personalized genomics, and ancient DNA. No prerequisites. Course includes primers on Molecular Biology, the UCSC Genome Browser, and text processing languages, and guest lectures from the forefront of genomic research. See http://cs273a.stanford.edu/