1 - 10 of 72 results for: BIOE

Preference to freshmen. The biomechanics and mechanobiology of the musculoskeletal system in human beings and other vertebrates on the level of the whole organism, organ systems, tissues, and cell biology. Field trips to labs.

The innate immune system provides our first line of defense against disease--both infections, and cancer. Innate immune effectors such as host defense peptides are deployed by numerous cell types (for instance neutrophils, macrophages, NK cells, epithelial cells and keratinocytes) and work by biophysical mechanisms of action. The ourse draws from the primary literature and covers the evolution, structures, mechanisms,and physiological functions of important "innate immune effectors" (components of the innate immune system that can attack pathogens, and infected or host cells, and kill or incapacitate them directly). The course is aimed at students who have an interest in biochemistry, molecular/cellular biology, biophysics, and/or bioengineering.

Principles of statistical physics, thermodynamics, and kinetics with applications to molecular biology. Topics include entropy, temperature, chemical forces, enzyme kinetics, free energy and its uses, self assembly, cooperative transitions in macromolecules, molecular machines, feedback, and accurate replication. Prerequisites: MATH 41, 42; CHEM 31A, B (or 31X); strongly recommended: PHYSICS 41, CME 100 or MATH 51, and CME 106; or instructor approval.

Principles of transport, continuum mechanics, and fluids, with applications to cell biology. Topics include random walks, diffusion, Langevin dynamics, transport theory, low Reynolds number flow, and beam theory, with applications including quantitative models of protein trafficking in the cell, mechanics of the cell cytoskeleton, the effects of molecular noise in development, the electromagnetics of nerve impulses, and an introduction to cardiovascular fluid flow. Prerequisites: MATH 41, 42; CHEM 31A, B (or 31X); strongly recommended: CS 106A, PHYSICS 41, CME 100 or MATH 51, and CME 106; or instructor approval. 4 units, Spr (Huang, K)

Introduction to next-generation techniques in genetic, molecular, biochemical, and cellular engineering. Lab modules build upon current research including: gene and genome engineering via decoupled design and construction of genetic material; component engineering focusing on molecular design and quantitative analysis of experiments; device and system engineering using abstracted genetically encoded objects; and product development based on useful applications of biological technologies.

Innovative new sequencing technologies are permitting the generation of massive amounts of sequence data and changing the way we think about and pursue biological questions. Coupled to these opportunities are tremendous challenges for biologists to grapple with the manipulation and analysis of large datasets and to address quantitative questions on a systems scale. The goal of this course is to provide biologists with basic computational tools and knowledge to confront large datasets in a quantitative manner. Students will learn basic programming skills in Matlab and Perl. Covered material will include: image analysis, bioinformatics algorithms, reaction-diffusion modeling, Monte Carlo algorithms, and population dynamics. Students will apply computational skills to a miniature research project studying the human microbiome or biofuel-related photosynthetic microbial communities. Spr 2012, (Huang, K., Sonnenburg, J., and Vora, T.)

Fundamental human anatomy, spanning major body systems and tissues including nerve, muscle, bone, cardiovascular, respiratory, gastrointestinal, and renal systems. Explore intricacies of structure and function, and how various body parts come together to form a coherent and adaptable living being. Correlate clinical conditions and therapeutic interventions. Participate in lab sessions with predissected cadaveric material and hands-on learning to gain understanding of the bioengineering human application domain. Encourage anatomical thinking, defining challenges and opportunities for bioengineers.

Preference to sophomores. Introduces students to the design of medical technologies and the non-technical factors that impact their clinical adoption and market success. Guest speakers include engineers, doctors, and other professionals who have helped bring ideas from concept to clinical use. Hands-on design projects will challenge students to invent their own solutions to clinical needs. No previous engineering training is required.

Broad but rigorous overview of the field of bioengineering, centered around the common theme of engineering analysis and design of biological systems. Topics include biomechanics, systems and synthetic biology, physical biology, biomolecular engineering, tissue engineering, and devices. Emphasis on critical thinking and problem solving approaches, and quantitative methods applied to biology. 4 units, Spr (Cochran)